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| Name | 5-hydroxytryptamine receptor 1D |
|---|---|
| Species | Rattus norvegicus (Rat) |
| Gene | Htr1d |
| Synonym | 5-HT1D receptor HTRL Htr1db HT1DA Gpcr14 [ Show all ] |
| Disease | N/A for non-human GPCRs |
| Length | 374 |
| Amino acid sequence | MSLPNQSLEGLPQEASNRSLNATGAWDPEVLQALRISLVVVLSIITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWAISICISIPPLFWRQATAHEEMSDCLVNTSQISYTIYSTCGAFYIPSILLIILYGRIYVAARSRILNPPSLYGKRFTTAQLITGSAGSSLCSLNPSLHESHTHTVGSPLFFNQVKIKLADSILERKRISAARERKATKTLGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPVIYTVFNEDFRQAFQRVVHFRKAS |
| UniProt | P28565 |
| Protein Data Bank | N/A |
| GPCR-HGmod model | N/A |
| 3D structure model | No available structures or models |
| BioLiP | N/A |
| Therapeutic Target Database | N/A |
| ChEMBL | CHEMBL5450 |
| IUPHAR | 3 |
| DrugBank | N/A |
You can:
| GLASS ID | Molecule | Formula | Molecular weight | H-bond acceptor / donor | XlogP | Lipinski's druglikeness |
|---|---|---|---|---|---|---|
| 13678 |  8-OH-Dpat | C16H25NO | 247.382 | 2 / 1 | 4.1 | Yes |
| 26600 |  Yohimbine | C21H26N2O3 | 354.45 | 4 / 2 | 2.9 | Yes |
| 27798 |  CHEMBL279646 | C25H30FN5O2 | 451.546 | 5 / 2 | 3.1 | Yes |
| 34708 |  CHEMBL274922 | C27H34N6O3 | 490.608 | 5 / 3 | 2.3 | Yes |
| 38624 |  3-[2-[4-[4-(trifluoromethyl)phenyl]piperazin-1-yl]ethyl]-1H-benzimidazol-2-one | C20H21F3N4O | 390.41 | 6 / 1 | 3.3 | Yes |
| 44544 |  CHEMBL276031 | C19H26N2O | 298.43 | 2 / 1 | 3.9 | Yes |
| 61272 |  CHEMBL3262407 | C20H27N3O | 325.456 | 4 / 1 | 3.7 | Yes |
| 62235 |  spiperone | C23H26FN3O2 | 395.478 | 5 / 1 | 3.0 | Yes |
| 65419 |  CHEMBL279320 | C27H36FN5O3 | 497.615 | 6 / 3 | 3.4 | Yes |
| 70241 |  CHEMBL99584 | C19H20N2O4 | 340.379 | 5 / 2 | 1.1 | Yes |
| 74194 |  CHEMBL15965 | C28H37FN6O2 | 508.642 | 6 / 3 | 3.3 | No |
| 76363 |  ondansetron | C18H19N3O | 293.37 | 2 / 0 | 2.3 | Yes |
| 78476 |  CHEMBL15139 | C23H29N5O3 | 423.517 | 5 / 4 | 2.6 | Yes |
| 90903 |  CHEMBL470432 | C19H25N3OS | 343.489 | 4 / 0 | 5.2 | No |
| 95371 |  CHEMBL15961 | C26H32FN5O2 | 465.573 | 5 / 2 | 3.5 | Yes |
| 96713 |  CHEMBL280314 | C25H31FN4O3 | 454.546 | 5 / 2 | 3.6 | Yes |
| 97935 |  CHEMBL430122 | C27H32N6O2 | 472.593 | 5 / 2 | 3.1 | Yes |
| 99023 |  CHEMBL84942 | C18H19N5O2 | 337.383 | 5 / 2 | 3.5 | Yes |
| 108097 |  CHEMBL317732 | C20H19ClFNO4 | 391.823 | 5 / 2 | 2.9 | Yes |
| 111190 |  CHEMBL15909 | C29H36FN5O2 | 505.638 | 5 / 3 | 3.8 | No |
| 115515 |  CHEMBL276928 | C27H31FN4O2 | 462.569 | 4 / 2 | 3.9 | Yes |
| 119098 |  SCHEMBL6346308 | C26H32FN5O2 | 465.573 | 5 / 2 | 3.5 | Yes |
| 122985 |  CHEMBL318022 | C20H19Cl2NO4 | 408.275 | 4 / 2 | 3.4 | Yes |
| 122987 |  CHEMBL95387 | C20H19Cl2NO4 | 408.275 | 4 / 2 | 3.4 | Yes |
| 123728 |  CHEMBL278917 | C26H32FN5O2 | 465.573 | 5 / 2 | 3.5 | Yes |
| 125489 |  CHEMBL99341 | C20H18Cl3NO4 | 442.717 | 4 / 2 | 4.0 | Yes |
| 159331 |  5-METHOXYTRYPTAMINE | C11H14N2O | 190.246 | 2 / 2 | 0.5 | Yes |
| 554093 |  [125I]GTI | C23H26IN5O5 | 577.396 | 6 / 6 | 1.3 | No |
| 170843 |  CHEMBL475331 | C13H17N5 | 243.314 | 5 / 1 | 1.6 | Yes |
| 171181 |  15532-75-9 | C11H13F3N2 | 230.234 | 5 / 1 | 2.3 | Yes |
| 172371 |  CHEMBL433377 | C18H19N3O4 | 341.367 | 6 / 2 | 0.4 | Yes |
| 172519 |  CHEMBL316885 | C20H20ClNO4 | 373.833 | 4 / 2 | 2.8 | Yes |
| 172521 |  CHEMBL98433 | C20H20ClNO4 | 373.833 | 4 / 2 | 2.8 | Yes |
| 175638 |  sumatriptan | C14H21N3O2S | 295.401 | 4 / 2 | 0.9 | Yes |
| 176699 |  RU 24969 | C14H16N2O | 228.295 | 2 / 2 | 1.8 | Yes |
| 180441 |  3-[(1,2,5,6-Tetrahydropyridin)-4-yl]-5H-pyrrolo[3,2-b]pyridin-5-one | C12H11N3O | 213.24 | 3 / 1 | -0.9 | Yes |
| 187213 |  CHEMBL3262393 | C24H25N3O | 371.484 | 3 / 2 | 4.8 | Yes |
| 197118 |  SCHEMBL12586671 | C33H37N5O5 | 583.689 | 6 / 3 | 2.4 | No |
| 198692 |  CGS 12066B | C17H17F3N4 | 334.346 | 6 / 0 | 4.0 | Yes |
| 204457 |  granisetron | C18H24N4O | 312.417 | 3 / 1 | 2.8 | Yes |
| 208074 |  CHEMBL100521 | C20H20ClNO4 | 373.833 | 4 / 2 | 2.8 | Yes |
| 208076 |  CHEMBL318906 | C20H20ClNO4 | 373.833 | 4 / 2 | 2.8 | Yes |
| 208078 |  CHEMBL98434 | C20H20ClNO4 | 373.833 | 4 / 2 | 2.8 | Yes |
| 208755 |  CHEMBL280000 | C28H37N5O2 | 475.637 | 4 / 2 | 4.4 | Yes |
| 212163 |  CHEMBL3262390 | C20H23N3O | 321.424 | 3 / 2 | 2.8 | Yes |
| 219968 |  Cilansetron | C20H21N3O | 319.408 | 2 / 0 | 2.6 | Yes |
| 219982 |  Imidazol-1-yl compound 1 | C20H21N3O | 319.408 | 2 / 0 | 2.6 | Yes |
| 228716 |  CHEMBL16035 | C23H28FN5O2 | 425.508 | 5 / 3 | 3.0 | Yes |
| 243310 |  CHEMBL15808 | C24H28FN5O2 | 437.519 | 5 / 2 | 2.8 | Yes |
| 261655 |  CP 93129 | C12H13N3O | 215.256 | 2 / 3 | -0.1 | Yes |
| 275926 |  CHEMBL3262432 | C27H34ClN3O2 | 468.038 | 4 / 2 | N/A | N/A |
| 277883 |  CHEMBL84107 | C18H19N5O2 | 337.383 | 5 / 3 | 3.6 | Yes |
| 280256 |  Thioperamide | C15H24N4S | 292.445 | 2 / 2 | 2.4 | Yes |
| 288327 |  buspirone | C21H31N5O2 | 385.512 | 6 / 0 | 2.6 | Yes |
| 289188 |  Cyanopindolol | C16H21N3O2 | 287.363 | 4 / 3 | 2.0 | Yes |
| 290296 |  serotonin | C10H12N2O | 176.219 | 2 / 3 | 0.2 | Yes |
| 291635 |  CHEMBL15855 | C26H33N5O2 | 447.583 | 4 / 2 | 3.4 | Yes |
| 292842 |  CHEMBL98214 | C20H20FNO4 | 357.381 | 5 / 2 | 2.3 | Yes |
| 292843 |  CHEMBL98388 | C20H20FNO4 | 357.381 | 5 / 2 | 2.3 | Yes |
| 299047 |  methiothepin | C20H24N2S2 | 356.546 | 4 / 0 | 4.2 | Yes |
| 307353 |  CHEMBL15837 | C29H39FN6O2 | 522.669 | 6 / 2 | 3.7 | No |
| 313483 |  Vilazodone | C26H27N5O2 | 441.535 | 5 / 2 | 4.0 | Yes |
| 554851 |  Donitriptan | C23H25N5O2 | 403.486 | 5 / 2 | 2.2 | Yes |
| 327156 |  CHEMBL314213 | C17H19N5O2 | 325.372 | 5 / 2 | 3.5 | Yes |
| 331353 |  CHEMBL560177 | C19H20ClN3O | 341.839 | 2 / 0 | 2.8 | Yes |
| 332574 |  UNII-3SH45L9H3Z | C15H19IN4S | 414.309 | 3 / 2 | 3.3 | Yes |
| 335000 |  (S)-mianserin | C18H20N2 | 264.372 | 2 / 0 | 3.4 | Yes |
| 355128 |  1-(3-Chlorophenyl)piperazine | C10H13ClN2 | 196.678 | 2 / 1 | 1.7 | Yes |
| 375972 |  5-Carboxamidotryptamine | C11H13N3O | 203.245 | 2 / 3 | -0.6 | Yes |
| 380743 |  CHEMBL98195 | C18H19NO4S | 345.413 | 5 / 2 | 1.8 | Yes |
| 385777 |  oxymetazoline | C16H24N2O | 260.381 | 2 / 2 | 2.9 | Yes |
| 386117 |  metergoline | C25H29N3O2 | 403.526 | 3 / 1 | 3.8 | Yes |
| 388279 |  ERGOTAMINE | C33H35N5O5 | 581.673 | 6 / 3 | 2.0 | No |
| 394895 |  CHEMBL38918 | C20H19ClFNO4 | 391.823 | 5 / 2 | 2.9 | Yes |
| 396255 |  CHEMBL15933 | C30H30N4O3 | 494.595 | 6 / 1 | 5.4 | No |
| 407098 |  148672-13-3 | C29H31N5O3 | 497.599 | 7 / 1 | 4.9 | Yes |
| 415893 |  CP 135807 | C19H21N5O2 | 351.41 | 5 / 2 | 4.1 | Yes |
| 555362 |  VORTIOXETINE | C18H22N2S | 298.448 | 3 / 1 | 4.2 | Yes |
| 418554 |  CHEMBL95250 | C20H19Cl2NO4 | 408.275 | 4 / 2 | 3.4 | Yes |
| 427070 |  CHEMBL318882 | C18H18ClNO4S | 379.855 | 5 / 2 | 2.8 | Yes |
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