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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	5-hydroxytryptamine receptor 1D
Species	Rattus norvegicus (Rat)
Gene	Htr1d
Synonym	5-HT1D receptor HTRL Htr1db HT1DA Gpcr14 5-HT-1D 5-HT1D 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled 5-HT1Dalpha Serotonin receptor 1D [ Show all ]
Disease	N/A for non-human GPCRs
Length	374
Amino acid sequence	MSLPNQSLEGLPQEASNRSLNATGAWDPEVLQALRISLVVVLSIITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWAISICISIPPLFWRQATAHEEMSDCLVNTSQISYTIYSTCGAFYIPSILLIILYGRIYVAARSRILNPPSLYGKRFTTAQLITGSAGSSLCSLNPSLHESHTHTVGSPLFFNQVKIKLADSILERKRISAARERKATKTLGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPVIYTVFNEDFRQAFQRVVHFRKAS
UniProt	P28565
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5450
IUPHAR	3
DrugBank	N/A

Ligand

Name	CHEMBL15965
Molecular formula	C28H37FN6O2
IUPAC name	1-[2-[4-(6-fluoro-1H-indol-3-yl)piperidin-1-yl]ethyl]-3-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]urea
Molecular weight	508.642
Hydrogen bond acceptor	6
Hydrogen bond donor	3
XlogP	3.3
Synonyms	1-[3-(4-Methylpiperazino)-4-methoxyphenyl]-3-[2-[4-(6-fluoro-1H-indole-3-yl)piperidino]ethyl]urea BDBM50086114 SCHEMBL6346305 1-{2-[4-(6-Fluoro-1H-indol-3-yl)-piperidin-1-yl]-ethyl}-3-[4-methoxy-3-(4-methyl-piperazin-1-yl)-phenyl]-urea
Inchi Key	FBHJLENKHMRXEZ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C28H37FN6O2/c1-33-13-15-35(16-14-33)26-18-22(4-6-27(26)37-2)32-28(36)30-9-12-34-10-7-20(8-11-34)24-19-31-25-17-21(29)3-5-23(24)25/h3-6,17-20,31H,7-16H2,1-2H3,(H2,30,32,36)
PubChem CID	10696986
ChEMBL	CHEMBL15965
IUPHAR	N/A
BindingDB	50086114
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
IC50	200.0 nM	PMID10737747	BindingDB,ChEMBL

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