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GPCR

Name5-hydroxytryptamine receptor 1D
SpeciesRattus norvegicus (Rat)
GeneHtr1d
Synonym5-HT1D receptor
HTRL
Htr1db
HT1DA
Gpcr14
[ Show all ]
DiseaseN/A for non-human GPCRs
Length374
Amino acid sequenceMSLPNQSLEGLPQEASNRSLNATGAWDPEVLQALRISLVVVLSIITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWAISICISIPPLFWRQATAHEEMSDCLVNTSQISYTIYSTCGAFYIPSILLIILYGRIYVAARSRILNPPSLYGKRFTTAQLITGSAGSSLCSLNPSLHESHTHTVGSPLFFNQVKIKLADSILERKRISAARERKATKTLGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPVIYTVFNEDFRQAFQRVVHFRKAS
UniProtP28565
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5450
IUPHAR3
DrugBankN/A

Ligand

NameCHEMBL15139
Molecular formulaC23H29N5O3
IUPAC name1-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-3-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]urea
Molecular weight423.517
Hydrogen bond acceptor5
Hydrogen bond donor4
XlogP2.6
SynonymsSCHEMBL6356822
1-[2-(5-Hydroxy-1H-indol-3-yl)-ethyl]-3-[4-methoxy-3-(4-methyl-piperazin-1-yl)-phenyl]-urea
BDBM50086102
Inchi KeyFHMGXDNSPPUJTF-UHFFFAOYSA-N
Inchi IDInChI=1S/C23H29N5O3/c1-27-9-11-28(12-10-27)21-13-17(3-6-22(21)31-2)26-23(30)24-8-7-16-15-25-20-5-4-18(29)14-19(16)20/h3-6,13-15,25,29H,7-12H2,1-2H3,(H2,24,26,30)
PubChem CID10764757
ChEMBLCHEMBL15139
IUPHARN/A
BindingDB50086102
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC50200.0 nMPMID10737747BindingDB,ChEMBL

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