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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	5-hydroxytryptamine receptor 1D
Species	Rattus norvegicus (Rat)
Gene	Htr1d
Synonym	5-HT1D receptor HTRL Htr1db HT1DA Gpcr14 5-HT-1D 5-HT1D 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled 5-HT1Dalpha Serotonin receptor 1D [ Show all ]
Disease	N/A for non-human GPCRs
Length	374
Amino acid sequence	MSLPNQSLEGLPQEASNRSLNATGAWDPEVLQALRISLVVVLSIITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWAISICISIPPLFWRQATAHEEMSDCLVNTSQISYTIYSTCGAFYIPSILLIILYGRIYVAARSRILNPPSLYGKRFTTAQLITGSAGSSLCSLNPSLHESHTHTVGSPLFFNQVKIKLADSILERKRISAARERKATKTLGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPVIYTVFNEDFRQAFQRVVHFRKAS
UniProt	P28565
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5450
IUPHAR	3
DrugBank	N/A

Ligand

Name	5-Carboxamidotryptamine
Molecular formula	C11H13N3O
IUPAC name	3-(2-aminoethyl)-1H-indole-5-carboxamide
Molecular weight	203.245
Hydrogen bond acceptor	2
Hydrogen bond donor	3
XlogP	-0.6
Synonyms	LS-82468 NCGC00024598-03 ZINC2539813 1H-Indole-5-carboxamide,3-(2-aminoethyl)- AKOS027380025 CHEMBL18840 GTPL4 NCGC00015182-03 RTR-033194 [3H]-5-Carboxyamidotryptamine 3-(2-aminoethyl)-1H-indole-5-carboxamide 74885-09-9 BPBio1_001405 Lopac-C-117 NCGC00024598-01 UNII-91H76044O0 AC1L1CAC CHEBI:48292 CTK5E0633 NCGC00015182-01 PDSP1_000774 [3H]-5-Carboxamide tryptamine 5-Carboxyamidotryptamine BDBM21392 KB-334392 NCGC00015182-04 SCHEMBL2677791 [3H]-5-CT 3-(2-aminoethyl)-1h-indole-5-carboxylic acid amide 91H76044O0 BRD-K92382976-103-01-8 Lopac0_000352 NCGC00024598-02 WKZLNEWVIAGNAW-UHFFFAOYSA-N 1H-Indole-5-carboxamide, 3-(2-aminoethyl)- 5-Carboxamide tryptamine AC1Q5DOI D02UWB NCGC00015182-02 PDSP2_000762 [3h]-5-carboxamidotryptamine 3-(2-AMINO-ETHYL)-1H-INDOLE-5-CARBOXYLIC ACID AMIDE 5-CT Biomol-NT_000109 L000077 NCGC00015182-05 Tocris-0458 3-(2-Aminoethyl-1H-indole-5-carboxamide A22556 CCG-204447 [ Show all ]
Inchi Key	WKZLNEWVIAGNAW-UHFFFAOYSA-N
Inchi ID	InChI=1S/C11H13N3O/c12-4-3-8-6-14-10-2-1-7(11(13)15)5-9(8)10/h1-2,5-6,14H,3-4,12H2,(H2,13,15)
PubChem CID	1809
ChEMBL	CHEMBL18840
IUPHAR	4
BindingDB	21392
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	0.37 nM	PMID7984267	BindingDB

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