You can:
| Name | Histamine H2 receptor |
|---|---|
| Species | Homo sapiens (Human) |
| Gene | HRH2 |
| Synonym | HH2R H2R Gastric receptor I H2 receptor |
| Disease | Ulcerative colitis Pain Peptic ulcer Gastroesophageal reflux disease Gastric ulcer [ Show all ] |
| Length | 359 |
| Amino acid sequence | MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSLAITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVMDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNEVYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHISSWKAATIREHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQQLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQVWSGTEVTAPQGATDR |
| UniProt | P25021 |
| Protein Data Bank | N/A |
| GPCR-HGmod model | P25021 |
| 3D structure model | This predicted structure model is from GPCR-EXP P25021. |
| BioLiP | N/A |
| Therapeutic Target Database | T30985 |
| ChEMBL | CHEMBL1941 |
| IUPHAR | 263 |
| DrugBank | BE0000112 |
You can:
| GLASS ID | Molecule | Formula | Molecular weight | H-bond acceptor / donor | XlogP | Lipinski's druglikeness |
|---|---|---|---|---|---|---|
| 374 |  CHEMBL1078529 | C16H20N6S | 328.438 | 4 / 3 | 2.2 | Yes |
| 530 |  AF-353 | C14H17IN4O2 | 400.22 | 6 / 2 | 2.8 | Yes |
| 764 |  CHEMBL1090526 | C20H24FN3O | 341.43 | 5 / 0 | 2.7 | Yes |
| 786 |  CHEMBL60435 | C23H33N3O3 | 399.535 | 5 / 1 | 1.8 | Yes |
| 1028 |  CHEMBL2205816 | C18H20N2O | 280.371 | 3 / 1 | 1.8 | Yes |
| 521483 |  CHEMBL3806146 | C14H20N6 | 272.356 | 3 / 3 | 1.7 | Yes |
| 521486 |  CHEMBL3804837 | C14H20N6 | 272.356 | 3 / 3 | 1.7 | Yes |
| 1789 |  ciproxifan | C16H18N2O2 | 270.332 | 3 / 1 | 2.5 | Yes |
| 2279 |  1-(cyclohexylmethyl)pyrrolidine | C11H21N | 167.296 | 1 / 0 | 3.1 | Yes |
| 3022 |  UNII-10521U3EQA | C23H31NO3S | 401.565 | 4 / 0 | 4.2 | Yes |
| 3134 |  AC1N0YGA | C3H7NO4S | 153.152 | 5 / 2 | -4.7 | Yes |
| 3329 |  CHEMBL3220637 | C11H18N6 | 234.307 | 3 / 3 | 0.8 | Yes |
| 3346 |  UR-AK68 | C16H21N5O | 299.378 | 3 / 3 | 2.1 | Yes |
| 3702 |  CHEMBL3220892 | C17H23N5O | 313.405 | 3 / 2 | 1.7 | Yes |
| 4471 |  UR-AK59 | C16H27N5O | 305.426 | 3 / 3 | 3.1 | Yes |
| 5061 |  BDBM50068818 | C32H39N5O6 | 589.693 | 8 / 2 | 2.9 | No |
| 5671 |  AC1L1HUK | C29H28ClN3O4 | 518.01 | 4 / 2 | 5.2 | No |
| 463722 |  CHEMBL3633757 | C26H24BrNO4 | 494.385 | 5 / 0 | 5.4 | No |
| 536129 |  CHEMBL3899832 | C22H19N5O4 | 417.425 | 8 / 2 | 3.6 | Yes |
| 7232 |  CHEMBL1258754 | C19H25N3O2 | 327.428 | 3 / 1 | 2.7 | Yes |
| 7844 |  CHEMBL1078210 | C17H22N6 | 310.405 | 3 / 3 | 2.3 | Yes |
| 8019 |  CHEMBL1258755 | C20H27N3O2 | 341.455 | 3 / 1 | 3.0 | Yes |
| 8523 |  CHEMBL60143 | C31H41N3O5 | 535.685 | 6 / 1 | 4.4 | No |
| 9865 |  AC-42 | C20H31NO | 301.474 | 2 / 0 | 5.2 | No |
| 10742 |  CHEMBL3287723 | C25H32O7 | 444.524 | 7 / 2 | 5.7 | No |
| 10995 |  CHEMBL1076586 | C26H23N3O2 | 409.489 | 2 / 1 | 4.1 | Yes |
| 11132 |  CHEMBL181278 | C27H34N2O5 | 466.578 | 6 / 1 | 1.6 | Yes |
| 11245 |  CHEMBL494982 | C17H21N3O | 283.375 | 3 / 1 | 2.9 | Yes |
| 11514 |  CHEMBL1257376 | C26H30FN3O2 | 435.543 | 4 / 0 | 4.5 | Yes |
| 11790 |  cimetidine | C10H16N6S | 252.34 | 4 / 3 | 0.4 | Yes |
| 13355 |  CHEMBL3220649 | C16H22N8S | 358.468 | 6 / 4 | 2.2 | Yes |
| 14651 |  CHEMBL1945848 | C25H28N4O2 | 416.525 | 5 / 0 | 3.7 | Yes |
| 15145 |  CHEMBL66388 | C21H29N3 | 323.484 | 3 / 1 | 4.8 | Yes |
| 15234 |  WAY-207024 | C30H32N6 | 476.628 | 5 / 1 | 5.5 | No |
| 15479 |  CHEMBL2205829 | C19H19NO3 | 309.365 | 4 / 1 | 2.2 | Yes |
| 521927 |  AM-0902 | C17H15ClN6O2 | 370.797 | 6 / 0 | 2.3 | Yes |
| 16286 |  CHEMBL64479 | C23H36N2O3 | 388.552 | 4 / 0 | 4.0 | Yes |
| 16638 |  CHEMBL60559 | C24H31N3O3S | 441.59 | 6 / 1 | 2.5 | Yes |
| 17151 |  CHEMBL2440659 | C15H11FN4O2S | 330.337 | 7 / 1 | 2.4 | Yes |
| 17461 |  CHEMBL1951055 | C20H30N2O3 | 346.471 | 5 / 0 | 2.6 | Yes |
| 17986 |  CHEMBL2031471 | C23H31N3O2 | 381.52 | 4 / 0 | 3.8 | Yes |
| 20062 |  CHEMBL2387282 | C22H33N5O2 | 399.539 | 4 / 1 | 1.7 | Yes |
| 20233 |  CHEMBL3220888 | C21H30N4O2 | 370.497 | 4 / 2 | 2.9 | Yes |
| 20779 |  CHEMBL1077861 | C9H14N6 | 206.253 | 3 / 3 | 0.0 | Yes |
| 522152 |  CHEMBL3775436 | C15H26ClNO3 | 303.827 | 4 / 3 | N/A | N/A |
| 522187 |  CHEMBL3775769 | C15H26ClNO3 | 303.827 | 4 / 3 | N/A | N/A |
| 22172 |  suloctidil | C20H35NOS | 337.566 | 3 / 2 | 5.8 | No |
| 22402 |  CHEMBL2013045 | C23H34N2O4S | 434.595 | 6 / 0 | 3.4 | Yes |
| 24184 |  CHEMBL44220 | C10H18N4S | 226.342 | 2 / 3 | 0.8 | Yes |
| 24232 |  CHEMBL64667 | C24H37N3O3 | 415.578 | 4 / 0 | 3.7 | Yes |
| 24726 |  CHEMBL1935426 | C23H33NO4S | 419.58 | 5 / 0 | 3.7 | Yes |
| 24830 |  CHEMBL1078746 | C18H26N6O | 342.447 | 3 / 4 | 2.4 | Yes |
| 26040 |  LISURIDE | C20H26N4O | 338.455 | 2 / 2 | 2.7 | Yes |
| 26291 |  CHEMBL600053 | C18H18FNO | 283.346 | 3 / 1 | 2.5 | Yes |
| 26488 |  CHEMBL374218 | C27H28N2O4 | 444.531 | 5 / 1 | 2.2 | Yes |
| 27179 |  CHEMBL2203713 | C18H22N4S | 326.462 | 4 / 2 | 2.9 | Yes |
| 27314 |  CHEMBL1078735 | C19H23N7 | 349.442 | 3 / 4 | 2.5 | Yes |
| 27491 |  CHEMBL2432063 | C19H29N | 271.448 | 1 / 0 | 4.7 | Yes |
| 27791 |  UR-AK46 | C14H23N5O | 277.372 | 3 / 3 | 2.0 | Yes |
| 28394 |  CHEMBL3124968 | C20H35N3O2 | 349.519 | 4 / 0 | 1.5 | Yes |
| 29047 |  CHEMBL214311 | C15H18ClN3 | 275.78 | 2 / 2 | 2.6 | Yes |
| 29056 |  CHEMBL213886 | C15H18ClN3 | 275.78 | 2 / 2 | 2.6 | Yes |
| 30213 |  SCHEMBL14542291 | C22H21NO3 | 347.414 | 3 / 0 | 4.3 | Yes |
| 30719 |  CHEMBL257606 | C20H32N6 | 356.518 | 6 / 0 | 2.2 | Yes |
| 30968 |  CHEMBL3220884 | C19H24N4O | 324.428 | 3 / 2 | 2.9 | Yes |
| 536793 |  CHEMBL3889627 | C23H27N5O3S | 453.561 | 5 / 2 | 2.6 | Yes |
| 32127 |  aspirin | C9H8O4 | 180.159 | 4 / 1 | 1.2 | Yes |
| 32216 |  CHEMBL104344 | C23H27ClN2O4S | 462.989 | 6 / 1 | 3.9 | Yes |
| 32436 |  CHEMBL3220653 | C16H23N9S | 373.483 | 7 / 5 | 2.2 | Yes |
| 32571 |  CHEMBL106596 | C21H24N2O2 | 336.435 | 4 / 1 | 3.5 | Yes |
| 32801 |  CHEMBL105071 | C27H36N2O4S | 484.655 | 6 / 1 | 5.0 | Yes |
| 33044 |  memantine | C12H21N | 179.307 | 1 / 1 | 3.3 | Yes |
| 33504 |  UNII-7W7511NPF8 | C20H20N2O3S | 368.451 | 6 / 1 | 1.8 | Yes |
| 33991 |  CHEMBL221413 | C26H31FN2O4 | 454.542 | 6 / 1 | 1.7 | Yes |
| 34591 |  CHEMBL1077636 | C12H20N6 | 248.334 | 3 / 3 | 1.2 | Yes |
| 34773 |  CHEMBL63003 | C30H35N3O3 | 485.628 | 5 / 1 | 4.0 | Yes |
| 34983 |  CHEMBL294502 | C22H34N2O3 | 374.525 | 4 / 0 | 3.6 | Yes |
| 35647 |  miconazole | C18H14Cl4N2O | 416.123 | 2 / 0 | 5.3 | No |
| 35865 |  CHEMBL292275 | C26H32N2O5 | 452.551 | 6 / 0 | 4.1 | Yes |
| 36766 |  CHEMBL3220886 | C19H24N4O | 324.428 | 3 / 2 | 2.9 | Yes |
| 36994 |  SNAP-5540 | C32H39N5O6 | 589.693 | 8 / 3 | 3.5 | No |
| 38495 |  CHEMBL2387289 | C22H30N4OS | 398.569 | 4 / 2 | 3.8 | Yes |
| 39478 |  CHEMBL221718 | C27H31F3N2O4 | 504.55 | 8 / 1 | 2.5 | No |
| 522738 |  CHEMBL494093 | C17H21N5 | 295.39 | 5 / 1 | 2.1 | Yes |
| 40319 |  Aripiprazole | C23H27Cl2N3O2 | 448.388 | 4 / 1 | 4.6 | Yes |
| 40480 |  CHEMBL61070 | C23H34N2O4 | 402.535 | 5 / 0 | 4.1 | Yes |
| 40985 |  UNII-67WL275ISI | C26H34N2O3 | 422.569 | 4 / 0 | 4.4 | Yes |
| 40996 |  A-349821 | C26H34N2O3 | 422.569 | 4 / 0 | 4.4 | Yes |
| 41215 |  CHEMBL62421 | C22H35N3O3 | 389.54 | 5 / 1 | 2.6 | Yes |
| 41679 |  CHEMBL1081318 | C16H20N6 | 296.378 | 3 / 3 | 2.0 | Yes |
| 41863 |  CHEMBL560386 | C23H29NO5S | 431.547 | 6 / 0 | 3.7 | Yes |
| 41912 |  CHEMBL64021 | C24H30N2O4 | 410.514 | 5 / 0 | 4.0 | Yes |
| 42471 |  CHEMBL2432039 | C20H23N | 277.411 | 1 / 1 | 2.7 | Yes |
| 43337 |  CHEMBL481153 | C19H20N2O2S | 340.441 | 4 / 0 | 3.9 | Yes |
| 43803 |  CHEMBL64884 | C25H35N3O3 | 425.573 | 4 / 0 | 3.9 | Yes |
| 43998 |  CHEMBL2432060 | C21H26FN | 311.444 | 2 / 0 | 4.8 | Yes |
| 44226 |  Cipargamin | C19H14Cl2FN3O | 390.239 | 3 / 3 | 3.9 | Yes |
| 522816 |  CHEMBL3805663 | C20H26N6 | 350.47 | 3 / 3 | 2.9 | Yes |
| 522817 |  CHEMBL3806098 | C20H26N6 | 350.47 | 3 / 3 | 2.9 | Yes |
| 45790 |  23981-80-8 | C14H14O3 | 230.263 | 3 / 1 | 3.3 | Yes |
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