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GPCR

NameHistamine H2 receptor
SpeciesHomo sapiens (Human)
GeneHRH2
SynonymHH2R
H2R
Gastric receptor I
H2 receptor
DiseaseUlcerative colitis
Pain
Peptic ulcer
Gastroesophageal reflux disease
Gastric ulcer
[ Show all ]
Length359
Amino acid sequenceMAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSLAITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVMDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNEVYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHISSWKAATIREHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQQLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQVWSGTEVTAPQGATDR
UniProtP25021
Protein Data BankN/A
GPCR-HGmod modelP25021
3D structure modelThis predicted structure model is from GPCR-EXP P25021.
BioLiPN/A
Therapeutic Target DatabaseT30985
ChEMBLCHEMBL1941
IUPHAR263
DrugBankBE0000112

Ligand

NameCHEMBL1081318
Molecular formulaC16H20N6
IUPAC name1-cyano-3-[2-(1H-imidazol-5-yl)ethyl]-2-(3-phenylpropyl)guanidine
Molecular weight296.378
Hydrogen bond acceptor3
Hydrogen bond donor3
XlogP2.0
SynonymsBDBM50415651
Inchi KeyCGWIQIDEPCKACR-UHFFFAOYSA-N
Inchi IDInChI=1S/C16H20N6/c17-12-21-16(20-10-8-15-11-18-13-22-15)19-9-4-7-14-5-2-1-3-6-14/h1-3,5-6,11,13H,4,7-10H2,(H,18,22)(H2,19,20,21)
PubChem CID44481485
ChEMBLCHEMBL1081318
IUPHARN/A
BindingDB50415651
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC50<10000.0 nMPMID19791743BindingDB,ChEMBL

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