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GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	UNII-67WL275ISI
Molecular formula	C26H34N2O3
IUPAC name	[4-[4-[3-[(2R,5R)-2,5-dimethylpyrrolidin-1-yl]propoxy]phenyl]phenyl]-morpholin-4-ylmethanone
Molecular weight	422.569
Hydrogen bond acceptor	4
Hydrogen bond donor	0
XlogP	4.4
Synonyms	A-349,821 Methanone, (4'-(3-((2R,5R)-2,5-dimethyl-1-pyrrolidinyl)propoxy)(1,1'-biphenyl)-4-yl)-4-morpholinyl- 372513-99-0 BDBM50158595 SCHEMBL7594032 CHEMBL179702 {4''''-[3-((2R,5R)-2,5-Dimethyl-pyrrolidin-1-yl)-propoxy]-biphenyl-4-yl}-morpholin-4-yl-methanone A-349821 Methanone,[4'-[3-[(2R,5R)-2,5-dimethyl-1-pyrrolidinyl]propoxy][1,1'-biphenyl]-4-yl]-4-morpholinyl- 4-[(4'-{3-[(2R,5R)-2,5-dimethylpyrrolidinyl]propoxy}[1,1'-biphenyl]-4-yl)carbonyl]morpholine CFUHKRLMDNFZED-NHCUHLMSSA-N 67WL275ISI KB-78395 {4''-[3-((2R,5R)-2,5-Dimethyl-pyrrolidin-1-yl)-propoxy]-biphenyl-4-yl}-morpholin-4-yl-methanone (4''-(3-((2R,5R)-2,5-dimethylpyrrolidin-1-yl)propoxy)biphenyl-4-yl)(morpholino)methanone A-349821 free base Morpholine, 4-((4'-(3-((2R,5R)-2,5-dimethyl-1-pyrrolidinyl)propoxy)(1,1'-biphenyl)-4-yl)carbonyl)- (9ci) 4-[3-[(2R)-2alpha,5beta-Dimethylpyrrolizino]propoxy]-4'-(morpholinocarbonyl)biphenyl ZINC3975242 [ Show all ]
Inchi Key	CFUHKRLMDNFZED-NHCUHLMSSA-N
Inchi ID	InChI=1S/C26H34N2O3/c1-20-4-5-21(2)28(20)14-3-17-31-25-12-10-23(11-13-25)22-6-8-24(9-7-22)26(29)27-15-18-30-19-16-27/h6-13,20-21H,3-5,14-19H2,1-2H3/t20-,21-/m1/s1
PubChem CID	9954017
ChEMBL	CHEMBL179702
IUPHAR	N/A
BindingDB	50158595
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
40985	Histamine H2 receptor	P25021	HRH2	Homo sapiens (Human)	359
40986	Histamine H3 receptor	Q9Y5N1	HRH3	Homo sapiens (Human)	445
40987	Histamine H3 receptor	Q9QYN8	Hrh3	Rattus norvegicus (Rat)	445
555632	Histamine H3 receptor	Q9JI35	HRH3	Cavia porcellus (Guinea pig)	445
40988	Histamine H4 receptor	Q9H3N8	HRH4	Homo sapiens (Human)	390

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