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GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	A-349821
Molecular formula	C26H34N2O3
IUPAC name	[4-[4-[3-[(2S,5S)-2,5-dimethylpyrrolidin-1-yl]propoxy]phenyl]phenyl]-morpholin-4-ylmethanone
Molecular weight	422.569
Hydrogen bond acceptor	4
Hydrogen bond donor	0
XlogP	4.4
Synonyms	BDBM50370569 A-349,821 CHEMBL27979
Inchi Key	CFUHKRLMDNFZED-SFTDATJTSA-N
Inchi ID	InChI=1S/C26H34N2O3/c1-20-4-5-21(2)28(20)14-3-17-31-25-12-10-23(11-13-25)22-6-8-24(9-7-22)26(29)27-15-18-30-19-16-27/h6-13,20-21H,3-5,14-19H2,1-2H3/t20-,21-/m0/s1
PubChem CID	44275807
ChEMBL	CHEMBL27979
IUPHAR	N/A
BindingDB	50370569
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
40991	Alpha-2C adrenergic receptor	P18825	ADRA2C	Homo sapiens (Human)	462
40990	D(4) dopamine receptor	P21917	DRD4	Homo sapiens (Human)	467
40995	Histamine H1 receptor	P35367	HRH1	Homo sapiens (Human)	487
40996	Histamine H2 receptor	P25021	HRH2	Homo sapiens (Human)	359
40989	Histamine H3 receptor	Q9Y5N1	HRH3	Homo sapiens (Human)	445
40992	Histamine H3 receptor	Q9QYN8	Hrh3	Rattus norvegicus (Rat)	445
40998	Histamine H4 receptor	Q9H3N8	HRH4	Homo sapiens (Human)	390
40993	Muscarinic acetylcholine receptor M1	P11229	CHRM1	Homo sapiens (Human)	460
40994	Muscarinic acetylcholine receptor M2	P08172	CHRM2	Homo sapiens (Human)	466
40997	Muscarinic acetylcholine receptor M3	P20309	CHRM3	Homo sapiens (Human)	590

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