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GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	DAMGO
Molecular formula	C26H35N5O6
IUPAC name	(2S)-2-amino-N-[(2R)-1-[[2-[[(2S)-1-(2-hydroxyethylamino)-1-oxo-3-phenylpropan-2-yl]-methylamino]-2-oxoethyl]amino]-1-oxopropan-2-yl]-3-(4-hydroxyphenyl)propanamide
Molecular weight	513.595
Hydrogen bond acceptor	7
Hydrogen bond donor	6
XlogP	0.2
Synonyms	DAMGE GTPL1647 NCGC00167303-01 Tyr-D-Ala-Gly-N(Me)Phe-Gly-ol [3H]DAMGO (2S)-2-amino-N-[(2R)-1-[[2-[[(2S)-1-(2-hydroxyethylamino)-1-oxo-3-phenylpropan-2-yl]-methylamino]-2-oxoethyl]amino]-1-oxopropan-2-yl]-3-(4-hydroxyphenyl)propanamide AKOS024456435 B6621 D-Ala2-MePhe4-Met(0)5-enkephalin-ol Enkephalin, ala(2)-mephe(4)-gly(5)- HPZJMUBDEAMBFI-WTNAPCKOSA-N Tyr-ala-gly-(nme)phe-gly-ol Tyr-D-Ala-Gly-NMe-Phe-Gly-ol (D-Ala(2)-mephe(4)-gly-ol(5))enkephalin 91418-78-9 C11318 DAGO FT-0772476 LS-105734 Tyr-D-Ala-Gly-MePhe-Gly-ol Tyr-DAla-Gly-MePhe-Gly-ol AC1NUWDS CHEMBL38874 H-Tyr-D-Ala-Gly-MePhe-Gly-ol RX 783006 Tyr-D-Ala-Gly-N-Me-Phe-Gly-ol [D-Ala2, NMe-Phe4, Gly-ol5]-enkephalin (2S)-2-[[2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]acetyl]-methylamino]-N-(2-hydroxyethyl)-3-phenylpropanamide 78123-71-4 Ala(2)-mephe(4)-gly-ol(5) enkephalin BDBM21015 D0F8CV Enkephalin, Ala(2)-MePhe(4)-Gly-ol(5)- HY-P0210 Tyr-D-Ala-Gly-(NMe)Phe-Gly-ol Tyr-D-Ala-Gly-NMePhe-Gly-ol (S)-2-amino-N-((R)-1-(2-(((S)-1-(2-hydroxyethylamino)-1-oxo-3-phenylpropan-2-yl)(methyl)amino)-2-oxoethylamino)-1-oxopropan-2-yl)-3-(4-hydroxyphenyl)propanamide 950492-85-0 CHEBI:272 Dagol glyol MolPort-023-276-021 Tyr-D-Ala-Gly-N(CH3)Phe-Gly-ol ZINC53092426 (2S)-2-amino-N-[(1R)-2-[[2-[[(1S)-1-benzyl-2-(2-hydroxyethylamino)-2-oxo-ethyl]-methyl-amino]-2-oxo-ethyl]amino]-1-methyl-2-oxo-ethyl]-3-(4-hydroxyphenyl)propanamide 2-Ala-4-mephe-5-gly-enkephalin AC1Q29AA CS-0021316 DTXSID30228775 H-Tyr-D-Ala-Gly-N-Me-Phe-Glycinol SCHEMBL725750 Tyr-D-Ala-Gly-N-Methyl-Phe-Gly-ol [tyrosyl-3,5-3H(N)]-D-Ala2-Mephe4-glyol5-enkephalin (2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydroxyphenyl)propanamido]propanamido]-N-methylacetamido}-N-(2-hydroxyethyl)-3-phenylpropanamide 83314-80-1 Ala2-MePhe4-Glyol5-Enkephalin C-54725 DAGn Enkephalin, alanyl(2)-methylphenylalanyl(4)-glycine(5)- L-Phenylalaninamide, L-tyrosyl-D-alanylglycyl-N-(2-hydroxyethyl)-Nalpha-methyl- Tyr-D-Ala-Gly-MePhe-Gly(ol) Tyr-D-Ala2-Gly-NMePhe-Gly-ol 117592-80-0 97777-48-5 [ Show all ]
Inchi Key	HPZJMUBDEAMBFI-WTNAPCKOSA-N
Inchi ID	InChI=1S/C26H35N5O6/c1-17(30-25(36)21(27)14-19-8-10-20(33)11-9-19)24(35)29-16-23(34)31(2)22(26(37)28-12-13-32)15-18-6-4-3-5-7-18/h3-11,17,21-22,32-33H,12-16,27H2,1-2H3,(H,28,37)(H,29,35)(H,30,36)/t17-,21+,22+/m1/s1
PubChem CID	5462471
ChEMBL	CHEMBL38874
IUPHAR	1647
BindingDB	21015
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand is heavier than 500 daltons.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
121174	Adenosine receptor A1	P30542	ADORA1	Homo sapiens (Human)	326
121177	Cannabinoid receptor 1	P21554	CNR1	Homo sapiens (Human)	472
121164	Delta-type opioid receptor	P33533	Oprd1	Rattus norvegicus (Rat)	372
121166	Delta-type opioid receptor	P41143	OPRD1	Homo sapiens (Human)	372
121173	Delta-type opioid receptor	P32300	Oprd1	Mus musculus (Mouse)	372
460320	Delta-type opioid receptor	P79291	OPRD1	Sus scrofa (Pig)	228
121170	Gastrin/cholecystokinin type B receptor	P32239	CCKBR	Homo sapiens (Human)	447
121163	Kappa-type opioid receptor	P41145	OPRK1	Homo sapiens (Human)	380
121165	Kappa-type opioid receptor	P34975	Oprk1	Rattus norvegicus (Rat)	380
121168	Kappa-type opioid receptor	P41144	OPRK1	Cavia porcellus (Guinea pig)	380
121172	Kappa-type opioid receptor	P33534	Oprk1	Mus musculus (Mouse)	380
121161	Mu-type opioid receptor	P33535	Oprm1	Rattus norvegicus (Rat)	398
121162	Mu-type opioid receptor	P35372	OPRM1	Homo sapiens (Human)	400
121167	Mu-type opioid receptor	P97266	OPRM1	Cavia porcellus (Guinea pig)	98
121169	Mu-type opioid receptor	P42866	Oprm1	Mus musculus (Mouse)	398
121176	Neuropeptides B/W receptor type 1	P48145	NPBWR1	Homo sapiens (Human)	328
121171	Nociceptin receptor	P41146	OPRL1	Homo sapiens (Human)	370
121178	Nociceptin receptor	P47748	OPRL1	Cavia porcellus (Guinea pig)	370
121175	Substance-P receptor	P14600	Tacr1	Rattus norvegicus (Rat)	407

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