Online Services

●I-TASSER ●I-TASSER-MTD ●C-I-TASSER ●CR-I-TASSER ●QUARK ●C-QUARK ●LOMETS ●MUSTER ●CEthreader ●SEGMER ●DeepFold ●DeepFoldRNA ●FoldDesign ●COFACTOR ●COACH ●MetaGO ●TripletGO ●IonCom ●FG-MD ●ModRefiner ●REMO ●DEMO ●DEMO-EM ●SPRING ●COTH ●Threpp ●PEPPI ●BSpred ●ANGLOR ●EDock ●BSP-SLIM ●SAXSTER ●FUpred ●ThreaDom ●ThreaDomEx ●EvoDesign ●BindProf ●BindProfX ●SSIPe ●GPCR-I-TASSER ●MAGELLAN ●ResQ ●STRUM ●DAMpred

●TM-score ●TM-align ●US-align ●MM-align ●RNA-align ●NW-align ●LS-align ●EDTSurf ●MVP ●MVP-Fit ●SPICKER ●HAAD ●PSSpred ●3DRobot ●MR-REX ●I-TASSER-MR ●SVMSEQ ●NeBcon ●ResPRE ●TripletRes ●DeepPotential ●WDL-RF ●ATPbind ●DockRMSD ●DeepMSA ●FASPR ●EM-Refiner ●GPU-I-TASSER

●BioLiP ●E. coli ●GLASS ●GPCR-HGmod ●GPCR-RD ●GPCR-EXP ●Tara-3D ●TM-fold ●DECOYS ●POTENTIAL ●RW/RWplus ●EvoEF ●HPSF ●THE-DB ●ADDRESS ●Alpaca-Antibody ●CASP7 ●CASP8 ●CASP9 ●CASP10 ●CASP11 ●CASP12 ●CASP13 ●CASP14

You can:

Check the GPCR table for details.
Go to the ligand list to see ligands that interacts with this GPCR.
Go to the individual ligand page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

GPCR

Name	Nociceptin receptor
Species	Cavia porcellus (Guinea pig)
Gene	OPRL1
Synonym	Kappa-type 3 opioid receptor KOR-3 Orphanin FQ receptor XOR
Disease	N/A for non-human GPCRs
Length	370
Amino acid sequence	MESLFPAPFWEVLYGSHLQGNLSLLSPNHSGLPPHLLLNASHSAFLPLGLKVTIVGLYLAVCIGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQATDILLGFWPFGNTLCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALALVVGVPVAIMGSAQVEDEEIECLVEIPDPQDYWGPVFAVSIFLFSFIIPVLIISVCYSLMIRRLHGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLVQGLGVQPGSETTVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALHREMQVSDRVRSIAKDVALGCKTTETVPRPA
UniProt	P47748
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5492
IUPHAR	N/A
DrugBank	N/A

Known ligands

You can:

Click GLASS IDs to check the association information.
Click ligand names to check details of the ligands.
Download a TSV version of all interaction information.
Download a SDF structure collection of all known ligands.

GLASS ID	Molecule	Formula	Molecular weight	H-bond acceptor / donor	XlogP	Lipinski's druglikeness
7985	CHEMBL378753	C26H27N3O4	445.519	6 / 3	3.5	Yes
15634	M3A6S	C19H21NO7S	407.437	7 / 1	-1.8	Yes
30361	morphine	C17H19NO3	285.343	4 / 2	0.8	Yes
69466	CHEMBL263588	C79H131FN28O20	1812.09	27 / 28	-9.0	No
86435	CHEMBL1418	C17H19NO6S	365.4	6 / 2	-2.0	Yes
91420	M3IBu6S	C21H25NO7S	435.491	7 / 1	-0.8	Yes
93500	CHEMBL410145	C82H141N35O21	1953.25	31 / 33	-13.3	No
106286	UFP-112	C83H139FN32O21	1940.23	29 / 34	-10.7	No
121178	DAMGO	C26H35N5O6	513.595	7 / 6	0.2	No
139415	M3B6S	C24H23NO7S	469.508	8 / 1	-0.1	Yes
152085	CHEMBL1417	C18H21NO6S	379.427	7 / 1	-1.5	Yes
180436	CHEMBL410653	C82H141N35O21	1953.25	31 / 33	-13.4	No
183237	CHEMBL264846	C79H129FN28O21	1826.07	27 / 28	-9.2	No
183737	BDBM50411363	C83H140N32O21	1922.24	28 / 31	-11.9	No
198133	M3Pr6S	C20H23NO7S	421.464	7 / 1	-1.4	Yes
215308	CHEMBL414782	C82H140FN35O21	1971.24	32 / 33	-13.3	No
221562	M3P6S	C22H27NO7S	449.518	8 / 1	-0.3	Yes
259098	CHEMBL1256748	C22H32N2O2	356.51	3 / 0	3.0	Yes
495077	U-69593	C22H32N2O2	356.51	3 / 0	3.0	Yes
269185	BDBM21842	C79H129N27O22	1809.07	27 / 28	-11.0	No
278271	CHEMBL437744	C84H142FN33O21	1969.27	30 / 32	-12.7	No
278277	CHEMBL2372052	C84H142FN33O21	1969.27	30 / 35	-11.6	No
282393	MM3A6S	C20H23NO7S	421.464	7 / 0	0.5	Yes
286192	DM6S	C17H21NO6S	367.416	7 / 2	-0.8	Yes
299933	MM3B6S	C25H25NO7S	483.535	7 / 0	2.1	Yes
312153	CHEMBL411621	C79H130N28O21	1808.08	26 / 28	-9.3	No
323577	CHEMBL262544	C82H143N35O20	1939.27	31 / 33	-13.1	No
334865	CHEMBL1415	C17H19NO6S	365.4	6 / 2	-2.1	Yes
335478	DC6S	C18H23NO6S	381.443	7 / 1	-0.5	Yes
347277	CHEMBL1783826	C26H33Cl2N3O	474.47	3 / 1	5.5	No
364169	122507-47-5	C30H38ClN5O7S2	680.232	10 / 7	0.0	No
371051	CHEMBL413944	C79H129FN28O21	1826.07	27 / 28	-9.2	No
393561	CHEMBL414767	C79H132N28O20	1794.1	26 / 28	-9.1	No
405549	DM3A6S	C19H23NO7S	409.453	8 / 1	-0.7	Yes
408504	DM3B6S	C24H25NO7S	471.524	8 / 1	0.9	Yes
408672	MET-enkephalin	C27H35N5O7S	573.665	9 / 7	-2.1	No

zhanglab

zhanggroup.org | +65-6601-1241 | Computing 1, 13 Computing Drive, Singapore 117417