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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
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GPCR

Name	Nociceptin receptor
Species	Cavia porcellus (Guinea pig)
Gene	OPRL1
Synonym	Kappa-type 3 opioid receptor KOR-3 Orphanin FQ receptor XOR
Disease	N/A for non-human GPCRs
Length	370
Amino acid sequence	MESLFPAPFWEVLYGSHLQGNLSLLSPNHSGLPPHLLLNASHSAFLPLGLKVTIVGLYLAVCIGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQATDILLGFWPFGNTLCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALALVVGVPVAIMGSAQVEDEEIECLVEIPDPQDYWGPVFAVSIFLFSFIIPVLIISVCYSLMIRRLHGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLVQGLGVQPGSETTVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALHREMQVSDRVRSIAKDVALGCKTTETVPRPA
UniProt	P47748
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5492
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL1415
Molecular formula	C17H19NO6S
IUPAC name	[(4R,4aR,7S,7aR,12bS)-7-hydroxy-3-methyl-1,2,3,4,4a,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-3-ium-9-yl] sulfate
Molecular weight	365.4
Hydrogen bond acceptor	6
Hydrogen bond donor	2
XlogP	-2.1
Synonyms	BDBM50189254
Inchi Key	UEMQCYWLMNLODZ-KOFBORESSA-N
Inchi ID	InChI=1S/C17H19NO6S/c1-18-7-6-17-10-3-4-12(19)16(17)23-15-13(24-25(20,21)22)5-2-9(14(15)17)8-11(10)18/h2-5,10-12,16,19H,6-8H2,1H3,(H,20,21,22)/t10-,11+,12-,16-,17-/m0/s1
PubChem CID	44414680
ChEMBL	CHEMBL1415
IUPHAR	N/A
BindingDB	50189254
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	1694.0 nM	PMID16777416	BindingDB,ChEMBL

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