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| Name | Cannabinoid receptor 1 |
|---|---|
| Species | Homo sapiens (Human) |
| Gene | CNR1 |
| Synonym | CB1 Central cannabinoid receptor SKR6R THC receptor CB1R [ Show all ] |
| Disease | Obesity; Diabetes Chemotherapy-induced nausea Diabetes; Obesity Drug abuse Hypertension; Diabetes; Obesity [ Show all ] |
| Length | 472 |
| Amino acid sequence | MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL |
| UniProt | P21554 |
| Protein Data Bank | 5tjv, 5u09, 5xr8, 5xra, 6n4b, 5tgz |
| GPCR-HGmod model | P21554 |
| 3D structure model | This structure is from PDB ID 5tjv. |
| BioLiP | BL0384680, BL0364157, BL0384679, BL0384681, BL0384682, BL0384683, BL0384684, BL0440253, BL0440254,BL0440255, BL0363267, BL0361447, BL0361446 |
| Therapeutic Target Database | T76685 |
| ChEMBL | CHEMBL218 |
| IUPHAR | 56 |
| DrugBank | BE0000061 |
You can:
| GLASS ID | Molecule | Formula | Molecular weight | H-bond acceptor / donor | XlogP | Lipinski's druglikeness |
|---|---|---|---|---|---|---|
| 17 |  CHEMBL2063242 | C23H23Cl2N3O3 | 460.355 | 4 / 1 | 4.7 | Yes |
| 25 |  N-(4-methoxybenzyl)oleamide | C26H43NO2 | 401.635 | 2 / 1 | 8.5 | No |
| 234 |  CHEMBL204391 | C23H16Cl3N3O2 | 472.75 | 3 / 1 | 4.8 | Yes |
| 277 |  CHEMBL2205617 | C21H20F4N2O3S | 456.456 | 8 / 1 | 4.3 | Yes |
| 441682 |  CHEMBL3322349 | C25H29Cl3N4O | 507.884 | 3 / 2 | 7.0 | No |
| 457 |  CHEMBL572080 | C30H29ClN4O2 | 513.038 | 5 / 2 | 6.2 | No |
| 464 |  CHEMBL294472 | C25H36O3 | 384.56 | 3 / 1 | 7.0 | No |
| 467 |  CHEMBL59540 | C25H36O3 | 384.56 | 3 / 1 | 7.0 | No |
| 506 |  CHEMBL481508 | C18H27N3O2S2 | 381.553 | 6 / 0 | 5.8 | No |
| 557 |  CHEMBL558564 | C20H20Cl5N5O | 523.664 | 4 / 3 | N/A | No |
| 533916 |  CHEMBL3937055 | C16H19F2N3O5S | 403.401 | 8 / 2 | 0.6 | Yes |
| 587 |  CHEMBL1223776 | C25H35N3O | 393.575 | 3 / 1 | 5.4 | No |
| 605 |  CHEMBL2153673 | C28H27Cl2N5O3S | 584.516 | 5 / 2 | 5.6 | No |
| 519702 |  CHEMBL3924062 | C21H28N4O3 | 384.48 | 6 / 1 | 4.2 | Yes |
| 665 |  CHEMBL392836 | C21H15Cl3N2O | 417.714 | 3 / 0 | 6.8 | No |
| 722 |  CHEMBL411504 | C24H31N3O4S | 457.589 | 6 / 0 | 4.1 | Yes |
| 519704 |  CHEMBL3915356 | C29H20Cl2F3N3O | 554.394 | 6 / 2 | 7.0 | No |
| 724 |  CHEMBL605109 | C29H26Cl2N4O3 | 549.452 | 4 / 2 | 4.6 | No |
| 859 |  CHEMBL1641939 | C26H32N2O2 | 404.554 | 3 / 1 | 5.7 | No |
| 535937 |  CHEMBL3936958 | C20H22F3N3O3S | 441.469 | 8 / 1 | 3.8 | Yes |
| 535939 |  CHEMBL3903525 | C19H24F2N4O4 | 410.422 | 9 / 1 | 2.8 | Yes |
| 1067 |  CHEMBL2205606 | C20H20F2N2O5S | 438.446 | 8 / 1 | 3.1 | Yes |
| 1141 |  CHEMBL1076680 | C19H16Cl2O3S | 395.294 | 4 / 1 | 5.3 | No |
| 1235 |  CHEMBL2113257 | C25H27ClN2O2 | 422.953 | 3 / 1 | 5.5 | No |
| 1313 |  CHEMBL1080908 | C23H25ClF3N5O2S | 527.991 | 8 / 1 | 4.8 | No |
| 1314 |  CHEMBL1080545 | C23H25ClF3N5O2S | 527.991 | 8 / 1 | 4.8 | No |
| 1317 |  CHEMBL1081213 | C23H25ClF3N5O2S | 527.991 | 8 / 1 | 4.8 | No |
| 519708 |  CHEMBL3908425 | C21H27F2N5O3 | 435.476 | 9 / 0 | 3.0 | Yes |
| 1551 |  875014-22-5 | C25H32N2OS | 408.604 | 2 / 1 | 7.4 | No |
| 1673 |  CHEMBL584528 | C20H21F4NO2 | 383.387 | 6 / 0 | 4.0 | Yes |
| 1681 |  CHEMBL2179751 | C29H35N3O2 | 457.618 | 3 / 2 | 5.6 | No |
| 2005 |  CHEMBL2152810 | C28H32N2O2S | 460.636 | 4 / 1 | 6.6 | No |
| 2025 |  CHEMBL271839 | C23H31NO2 | 353.506 | 2 / 0 | 4.7 | Yes |
| 535971 |  CHEMBL3925964 | C29H27ClF3N3O5S | 622.056 | 10 / 3 | 5.0 | No |
| 2041 |  CHEMBL478643 | C23H22BrNO | 408.339 | 1 / 1 | 5.8 | No |
| 2094 |  CHEMBL2163952 | C30H32N2O3 | 468.597 | 4 / 1 | 5.9 | No |
| 2221 |  CHEMBL485192 | C25H29N3O2 | 403.526 | 4 / 1 | 5.4 | No |
| 547922 |  CHEMBL3911884 | C15H21ClN2O3 | 312.794 | 4 / 2 | 2.3 | Yes |
| 557364 |  SCHEMBL15790159 | C15H21ClN2O3 | 312.794 | 4 / 2 | 2.3 | Yes |
| 535978 |  CHEMBL3911641 | C15H21ClN2O3 | 312.794 | 4 / 2 | 2.3 | Yes |
| 2348 |  CHEMBL1762420 | C18H28N4O4 | 364.446 | 5 / 1 | 1.2 | Yes |
| 441768 |  CHEMBL3401612 | C21H21Cl2N3O | 402.319 | 2 / 1 | 5.5 | No |
| 2365 |  CHEMBL475910 | C29H26BrNO | 484.437 | 1 / 1 | 7.3 | No |
| 2381 |  CHEMBL1801072 | C25H24FN5O4 | 477.496 | 7 / 2 | 3.7 | Yes |
| 535982 |  SCHEMBL17557589 | C28H28Cl2N4O3S | 571.517 | 7 / 2 | 5.6 | No |
| 3006 |  CHEMBL464916 | C21H27N3O | 337.467 | 3 / 2 | 4.8 | Yes |
| 3009 |  CHEMBL3114514 | C21H16FN3O | 345.377 | 3 / 2 | 4.3 | Yes |
| 463241 |  CHEMBL3605035 | C20H14Cl2O3 | 373.229 | 3 / 2 | 5.8 | No |
| 3067 |  CHEMBL511558 | C25H14Cl3N3O | 478.757 | 3 / 1 | 6.8 | No |
| 535987 |  BDBM118149 | C36H31Cl2N3O3 | 624.562 | 4 / 1 | 7.9 | No |
| 3074 |  CHEMBL2163572 | C29H38N4O3 | 490.648 | 6 / 1 | 4.2 | Yes |
| 3198 |  CHEMBL2030757 | C23H23Cl3N4O3S | 541.872 | 5 / 1 | 5.3 | No |
| 3207 |  CHEMBL398905 | C23H34O2 | 342.523 | 2 / 1 | 6.6 | No |
| 3285 |  CHEMBL229698 | C24H26ClN3O | 407.942 | 2 / 1 | 6.1 | No |
| 3335 |  CID 11668762 | C21H14Cl2N2OS | 413.316 | 2 / 0 | 6.0 | No |
| 536000 |  SCHEMBL16023414 | C17H18F2N6O | 360.369 | 8 / 0 | 2.2 | Yes |
| 536002 |  SCHEMBL17557608 | C34H30Cl2N4O5S | 677.597 | 9 / 2 | 7.5 | No |
| 3544 |  CHEMBL1765270 | C24H28N2O2 | 376.5 | 3 / 1 | 3.4 | Yes |
| 3564 |  CHEMBL515648 | C22H18ClFN4O | 408.861 | 6 / 0 | 5.3 | No |
| 3565 |  CHEMBL478202 | C22H18ClFN4O | 408.861 | 6 / 0 | 5.3 | No |
| 536007 |  SCHEMBL16222656 | C20H23ClN6O2S | 446.954 | 7 / 0 | 2.4 | Yes |
| 536010 |  SCHEMBL17557600 | C35H32Cl2N4O2 | 611.567 | 6 / 2 | 6.3 | No |
| 441857 |  SCHEMBL5643095 | C22H32ClN3O2 | 405.967 | 3 / 1 | N/A | N/A |
| 3737 |  CHEMBL449341 | C17H14Cl2N2O3S | 397.27 | 4 / 1 | 4.2 | Yes |
| 3971 |  CHEMBL1091832 | C25H20Cl2N2O4 | 483.345 | 5 / 2 | 6.3 | No |
| 4002 |  CHEMBL518505 | C23H22BrCl2N3O | 507.253 | 2 / 1 | 7.1 | No |
| 4047 |  CHEMBL15918 | C19H18Cl3N5O | 438.737 | 4 / 1 | 4.9 | Yes |
| 4063 |  AC1LP5MH | C19H16N2O2S | 336.409 | 4 / 0 | 4.1 | Yes |
| 536032 |  SCHEMBL16211797 | C18H21ClN6S | 388.918 | 6 / 0 | 3.9 | Yes |
| 4147 |  CHEMBL2347042 | C21H21Cl3N2 | 407.763 | 1 / 0 | 8.3 | No |
| 441880 |  CHEMBL3401608 | C20H19ClN2O3 | 370.833 | 3 / 2 | 4.9 | Yes |
| 4188 |  CID 56595575 | C24H28N4O2 | 404.514 | 4 / 0 | 2.7 | Yes |
| 4197 |  CHEMBL2316259 | C25H34N2O2S | 426.619 | 4 / 1 | 6.4 | No |
| 4263 |  CHEMBL2381791 | C29H36N4O2 | 472.633 | 4 / 1 | 6.4 | No |
| 4422 |  CHEMBL2071068 | C24H28ClN3O2 | 425.957 | 3 / 3 | 4.7 | Yes |
| 536044 |  SCHEMBL18548029 | C27H23Cl2F3N4O3S | 611.461 | 9 / 0 | 6.8 | No |
| 4555 |  UNII-4MC625LVID | C21H29NO2 | 327.468 | 2 / 1 | 4.1 | Yes |
| 547951 |  CHEMBL3930886 | C29H24Cl2N4O | 515.438 | 3 / 1 | 6.3 | No |
| 557414 |  SCHEMBL15776122 | C18H22FN3O3 | 347.39 | 5 / 1 | 2.1 | Yes |
| 547953 |  CHEMBL3891188 | C18H22FN3O3 | 347.39 | 5 / 1 | 2.1 | Yes |
| 536059 |  CHEMBL3898811 | C18H22FN3O3 | 347.39 | 5 / 1 | 2.1 | Yes |
| 536060 |  SCHEMBL18548061 | C37H36Cl2N4O4S | 703.679 | 6 / 1 | 7.3 | No |
| 4860 |  CHEMBL397690 | C18H19ClN2O2S | 362.872 | 4 / 1 | 3.8 | Yes |
| 4862 |  CHEMBL468919 | C18H19ClN2O2S | 362.872 | 4 / 1 | 3.8 | Yes |
| 536063 |  SCHEMBL18547958 | C35H33Cl2N3O3S | 646.627 | 5 / 0 | 8.0 | No |
| 5041 |  CHEMBL593606 | C23H19Cl2F2N3S | 478.383 | 5 / 1 | 6.5 | No |
| 5071 |  SCHEMBL2485239 | C24H32Cl2N6O | 491.461 | 6 / 1 | N/A | N/A |
| 555501 |  PhAR, Cycloproyl | C26H43NO4 | 433.633 | 4 / 2 | 7.0 | No |
| 5117 |  CHEMBL225414 | C21H18Br2N2O2 | 490.195 | 2 / 3 | 4.6 | Yes |
| 5224 |  CHEMBL511907 | C25H27Cl3N4O | 505.868 | 3 / 1 | 7.8 | No |
| 5258 |  CHEMBL157591 | C24H20ClF3N4O2S | 520.955 | 7 / 1 | 5.5 | No |
| 5285 |  CHEMBL262858 | C24H22N2O3 | 386.451 | 4 / 0 | 4.3 | Yes |
| 557426 |  SCHEMBL17557708 | C33H28Cl2N4O2 | 583.513 | 6 / 2 | 5.5 | No |
| 5330 |  CHEMBL600426 | C23H35NO | 341.539 | 2 / 0 | 7.4 | No |
| 5340 |  CHEMBL2010905 | C19H28N2O3S | 364.504 | 4 / 2 | 3.7 | Yes |
| 5430 |  CHEMBL2170545 | C22H32N2O2 | 356.51 | 3 / 1 | 4.3 | Yes |
| 5515 |  Org 27569 | C24H28ClN3O | 409.958 | 2 / 2 | 6.0 | No |
| 441914 |  CHEMBL3347311 | C22H31Cl2N3O | 424.41 | 2 / 1 | N/A | N/A |
| 5570 |  CHEMBL1209670 | C27H26ClF3N2O2 | 502.962 | 6 / 0 | 6.6 | No |
| 519722 |  CHEMBL3970448 | C17H21N3O2 | 299.374 | 4 / 1 | 2.8 | Yes |
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