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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Nociceptin receptor
Species	Homo sapiens (Human)
Gene	OPRL1
Synonym	Orphanin FQ receptor OP4 NOPr NOP-r NOP receptor NOCIR nociceptin/orphanin FQ receptor Kappa-type 3 opioid receptor kappa3-related opioid receptor KOR-3 MOR-C N/OFQ receptor nociceptin receptor ORL1 XOR1 [ Show all ]
Disease	Inflammatory disease Major depressive disorder Central nervous system disease Heart failure Anxiety disorder Pain Pain; Stress Psychiatric disorder [ Show all ]
Length	370
Amino acid sequence	MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
UniProt	P41146
Protein Data Bank	5dhh, 5dhg, 4ea3
GPCR-HGmod model	P41146
3D structure model	This structure is from PDB ID 5dhh.
BioLiP	BL0328039,BL0328040, BL0328041,BL0328042, BL0227293,BL0227294
Therapeutic Target Database	T52921
ChEMBL	CHEMBL2014
IUPHAR	320
DrugBank	BE0002378

Ligand

Name	DAMGO
Molecular formula	C26H35N5O6
IUPAC name	(2S)-2-amino-N-[(2R)-1-[[2-[[(2S)-1-(2-hydroxyethylamino)-1-oxo-3-phenylpropan-2-yl]-methylamino]-2-oxoethyl]amino]-1-oxopropan-2-yl]-3-(4-hydroxyphenyl)propanamide
Molecular weight	513.595
Hydrogen bond acceptor	7
Hydrogen bond donor	6
XlogP	0.2
Synonyms	Tyr-D-Ala-Gly-NMePhe-Gly-ol (S)-2-amino-N-((R)-1-(2-(((S)-1-(2-hydroxyethylamino)-1-oxo-3-phenylpropan-2-yl)(methyl)amino)-2-oxoethylamino)-1-oxopropan-2-yl)-3-(4-hydroxyphenyl)propanamide 950492-85-0 BDBM21015 D0F8CV Enkephalin, Ala(2)-MePhe(4)-Gly-ol(5)- HY-P0210 Tyr-D-Ala-Gly-(NMe)Phe-Gly-ol Tyr-D-Ala-Gly-N(CH3)Phe-Gly-ol ZINC53092426 (2S)-2-amino-N-[(1R)-2-[[2-[[(1S)-1-benzyl-2-(2-hydroxyethylamino)-2-oxo-ethyl]-methyl-amino]-2-oxo-ethyl]amino]-1-methyl-2-oxo-ethyl]-3-(4-hydroxyphenyl)propanamide 2-Ala-4-mephe-5-gly-enkephalin AC1Q29AA CHEBI:272 Dagol glyol MolPort-023-276-021 Tyr-D-Ala-Gly-N-Methyl-Phe-Gly-ol [tyrosyl-3,5-3H(N)]-D-Ala2-Mephe4-glyol5-enkephalin (2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydroxyphenyl)propanamido]propanamido]-N-methylacetamido}-N-(2-hydroxyethyl)-3-phenylpropanamide 83314-80-1 Ala2-MePhe4-Glyol5-Enkephalin CS-0021316 DTXSID30228775 H-Tyr-D-Ala-Gly-N-Me-Phe-Glycinol SCHEMBL725750 Tyr-D-Ala2-Gly-NMePhe-Gly-ol 117592-80-0 97777-48-5 C-54725 DAGn Enkephalin, alanyl(2)-methylphenylalanyl(4)-glycine(5)- L-Phenylalaninamide, L-tyrosyl-D-alanylglycyl-N-(2-hydroxyethyl)-Nalpha-methyl- Tyr-D-Ala-Gly-MePhe-Gly(ol) Tyr-D-Ala-Gly-N(Me)Phe-Gly-ol [3H]DAMGO (2S)-2-amino-N-[(2R)-1-[[2-[[(2S)-1-(2-hydroxyethylamino)-1-oxo-3-phenylpropan-2-yl]-methylamino]-2-oxoethyl]amino]-1-oxopropan-2-yl]-3-(4-hydroxyphenyl)propanamide AKOS024456435 DAMGE GTPL1647 NCGC00167303-01 Tyr-D-Ala-Gly-NMe-Phe-Gly-ol (D-Ala(2)-mephe(4)-gly-ol(5))enkephalin 91418-78-9 B6621 D-Ala2-MePhe4-Met(0)5-enkephalin-ol Enkephalin, ala(2)-mephe(4)-gly(5)- HPZJMUBDEAMBFI-WTNAPCKOSA-N Tyr-ala-gly-(nme)phe-gly-ol Tyr-DAla-Gly-MePhe-Gly-ol AC1NUWDS C11318 DAGO FT-0772476 LS-105734 Tyr-D-Ala-Gly-MePhe-Gly-ol Tyr-D-Ala-Gly-N-Me-Phe-Gly-ol [D-Ala2, NMe-Phe4, Gly-ol5]-enkephalin (2S)-2-[[2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]acetyl]-methylamino]-N-(2-hydroxyethyl)-3-phenylpropanamide 78123-71-4 Ala(2)-mephe(4)-gly-ol(5) enkephalin CHEMBL38874 H-Tyr-D-Ala-Gly-MePhe-Gly-ol RX 783006 [ Show all ]
Inchi Key	HPZJMUBDEAMBFI-WTNAPCKOSA-N
Inchi ID	InChI=1S/C26H35N5O6/c1-17(30-25(36)21(27)14-19-8-10-20(33)11-9-19)24(35)29-16-23(34)31(2)22(26(37)28-12-13-32)15-18-6-4-3-5-7-18/h3-11,17,21-22,32-33H,12-16,27H2,1-2H3,(H,28,37)(H,29,35)(H,30,36)/t17-,21+,22+/m1/s1
PubChem CID	5462471
ChEMBL	CHEMBL38874
IUPHAR	1647
BindingDB	21015
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
Emax	0.0 %	PMID19683449	ChEMBL
Ki	<10000.0 nM	PMID21866885	BindingDB,ChEMBL

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