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You can:

Check the GPCR table for details.
Go to the ligand list to see ligands that interacts with this GPCR.
Go to the individual ligand page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

GPCR

Name	Gonadotropin-releasing hormone receptor
Species	Homo sapiens (Human)
Gene	GNRHR
Synonym	LHRHR GnRH I receptor Type I GnRHR gnRH receptor GnRH-R LHRH receptor GnRHR GNRHR1 luteinizing hormone-releasing hormone (LHRH) receptor luliberin receptor GnRH1 receptor [ Show all ]
Disease	Uterine leiomyoma Hypothalamic hypogonadism Ovulation Prostate cancer Prostate disease Prostate hyperplasia Unspecified Female infertility Esophageal cancer Endometriosis Controlled ovarian stimulation Cancer Advanced prostate cancer Acute lymphoblastic leukemia Hormone deficiency [ Show all ]
Length	328
Amino acid sequence	MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKLQKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYLKLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRMIHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTRVLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRLSDPVNHFFFLFAFLNPCFDPLIYGYFSL
UniProt	P30968
Protein Data Bank	N/A
GPCR-HGmod model	P30968
3D structure model	This predicted structure model is from GPCR-EXP P30968.
BioLiP	N/A
Therapeutic Target Database	T12475
ChEMBL	CHEMBL1855
IUPHAR	256
DrugBank	BE0000203

Known ligands

You can:

Click GLASS IDs to check the association information.
Click ligand names to check details of the ligands.
Download a TSV version of all interaction information.
Download a SDF structure collection of all known ligands.

GLASS ID	Molecule	Formula	Molecular weight	H-bond acceptor / donor	XlogP	Lipinski's druglikeness
15	CHEMBL1800663	C36H32F2N6O4S	682.747	9 / 2	5.5	No
919	CHEMBL119774	C29H34F3N3O3	529.604	7 / 0	5.6	No
1110	CHEMBL437260	C88H86F4N16O12	1635.75	22 / 8	9.5	No
1572	CHEMBL324759	C29H30F2N4O3	520.581	7 / 0	4.0	No
1574	CHEMBL112466	C29H30F2N4O3	520.581	7 / 0	4.0	No
1575	CHEMBL113151	C29H30F2N4O3	520.581	7 / 0	4.0	No
2247	CHEMBL265879	C83H105ClN18O16	1646.31	18 / 16	3.7	No
2357	CHEMBL117504	C29H34F3N3O3	529.604	7 / 1	5.4	No
2998	CHEMBL416651	C29H31ClN6O3	547.056	6 / 4	3.6	No
3246	CHEMBL417645	C29H29F3N4O3	538.571	8 / 0	4.1	No
3366	CHEMBL130607	C34H31F2N5O4	611.65	10 / 0	5.1	No
3635	CHEMBL219461	C78H103ClN18O16	1584.24	18 / 17	2.4	No
3671	CHEMBL468551	C28H24F5N3O3	545.51	9 / 1	4.5	No
3990	CHEMBL1091579	C28H34N6O2	486.62	5 / 1	4.2	Yes
4039	CHEMBL22937	C32H30F2N4O2	540.615	6 / 0	5.3	No
4274	CHEMBL181582	C27H25N3O4	455.514	5 / 1	3.1	Yes
4621	CHEMBL113432	C39H50N4O2	606.855	4 / 3	6.7	No
4743	CHEMBL50546	C34H38FN5O2	567.709	7 / 0	6.3	No
5350	CHEMBL401418	C37H54N6O2S	646.939	7 / 3	4.8	No
6603	Abarelix	C72H95ClN14O14	1416.09	16 / 13	3.7	No
7096	CHEMBL411381	C79H104ClN19O18	1643.27	19 / 19	1.8	No
7195	CHEMBL71793	C36H40FN5O5	641.744	9 / 1	5.9	No
7425	CHEMBL372316	C24H31N5O4S	485.603	6 / 2	4.8	Yes
7636	CHEMBL392604	C31H31Cl2F2N5O2	614.519	7 / 0	4.7	No
8740	CHEMBL116074	C30H30F3N3O3	537.583	7 / 0	5.2	No
9009	CHEMBL407023	C64H103N21O13	1374.66	18 / 18	-1.0	No
9930	CHEMBL73454	C27H25F4N3O5	547.507	10 / 2	N/A	No
10377	Relugolix	C29H27F2N7O5S	623.636	11 / 2	3.2	No
10571	CHEMBL211731	C36H36F2N4O3S	642.766	8 / 2	6.9	No
10617	CHEMBL420051	C41H54N4O	618.91	3 / 2	9.1	No
11236	CHEMBL411565	C84H106ClN17O16	1645.32	18 / 16	4.0	No
11297	CHEMBL212207	C33H32N2O4S	552.689	7 / 0	6.6	No
11302	CHEMBL439076	C49H50F2N8O6	884.986	11 / 4	6.7	No
11457	CHEMBL2370818	C74H106ClN23O12	1545.26	22 / 18	4.7	No
11588	CHEMBL235180	C40H41F2N13O5	821.851	14 / 3	4.2	No
12009	CHEMBL238377	C43H49F2N13O6	881.947	15 / 3	4.1	No
12049	CHEMBL2113012	C25H24F2N4O3	466.489	6 / 1	3.2	Yes
12143	CHEMBL352051	C40H47N5O3	645.848	5 / 4	5.3	No
12236	CHEMBL68985	C37H34FN5O4	631.708	9 / 0	6.0	No
12379	CHEMBL506338	C32H30F5N3O6	647.599	12 / 2	2.2	No
12509	CHEMBL454088	C21H21F3N6OS	462.495	8 / 3	3.2	Yes
12557	CHEMBL291896	C33H32F2N6O5	630.653	10 / 2	4.4	No
12669	CHEMBL299348	C34H36FN5O4	597.691	9 / 0	4.9	No
13576	CHEMBL185438	C28H29ClN4O3S	537.075	6 / 2	6.5	No
13588	CHEMBL364933	C26H28N6O4S	520.608	7 / 2	4.1	No
13796	CHEMBL265020	C83H103ClN18O18	1676.3	20 / 16	2.7	No
14422	CHEMBL399857	C37H50N4O3S	630.892	5 / 1	6.2	No
14757	CHEMBL120834	C33H43ClN4O2	563.183	5 / 2	9.0	No
14986	CHEMBL235519	C31H35ClF2N4O2	569.094	6 / 0	5.0	No
15030	CHEMBL1800667	C33H34F2N6O6S2	712.788	11 / 2	3.9	No
15218	CID 44398121	C82H99ClN20O16	1656.27	19 / 18	1.9	No
15233	WAY-207024	C30H32N6	476.628	5 / 1	5.5	No
15618	CHEMBL175711	C26H21F5N4O4	548.47	10 / 1	4.1	No
15720	CHEMBL365985	C26H21F4N3O2	483.467	7 / 1	4.1	Yes
15928	CHEMBL236221	C46H53F2N13O8	954.01	17 / 3	3.8	No
16615	CHEMBL301103	C31H37FN4O5	564.658	9 / 0	4.3	No
16672	CHEMBL506877	C31H30F3N3O5	581.592	9 / 2	1.8	No
17182	CHEMBL116246	C27H33N3O2	431.58	4 / 1	5.8	No
17656	CHEMBL326510	C22H23F2N3O3	415.441	6 / 1	2.6	Yes
17657	CHEMBL322283	C22H23F2N3O3	415.441	6 / 1	2.6	Yes
17743	CHEMBL236331	C31H32ClF2N5O2	580.077	7 / 0	4.1	No
17752	CHEMBL260750	C92H90F4N16O12	1687.83	22 / 6	10.1	No
17850	CHEMBL68664	C32H31FN4O4	554.622	8 / 0	5.2	No
18753	CHEMBL406337	C79H101ClN16O14	1534.22	16 / 15	4.8	No
18859	CHEMBL452541	C22H23F3N6OS	476.522	8 / 2	3.2	Yes
19092	CHEMBL181864	C23H21ClFN3O3S	473.947	6 / 1	4.9	Yes
19880	CHEMBL454089	C21H22N6O3S	438.506	6 / 4	1.3	Yes
20308	CHEMBL395225	C37H37F4N5O	643.731	8 / 2	6.4	No
20572	CHEMBL392008	C86H94F4N20O14	1707.82	28 / 6	5.8	No
20759	CHEMBL499849	C29H26F4N4O4	570.545	10 / 3	0.8	No
21457	CHEMBL433594	C28H30ClN5O3S	552.09	7 / 3	4.8	No
21723	CHEMBL180372	C25H21ClF2N4O4	514.914	7 / 1	3.8	No
21811	CHEMBL487627	C21H18F6N6	468.407	10 / 2	4.3	Yes
21878	CHEMBL117069	C36H38F2N4O4	628.721	9 / 0	6.7	No
22588	CHEMBL235302	C30H32F2N6O2	546.623	8 / 0	2.4	No
23443	CHEMBL364246	C28H31N5O4S	533.647	6 / 2	5.5	No
24221	CHEMBL210277	C33H31FN2O4S	570.679	8 / 0	6.7	No
24302	CHEMBL325326	C30H30F2N4O3	532.592	7 / 0	4.1	No
24303	CHEMBL431248	C30H30F2N4O3	532.592	7 / 0	4.1	No
25166	CHEMBL131665	C41H42FN5O4	687.816	9 / 0	7.2	No
548169	Gestrinone	C21H24O2	308.421	2 / 1	2.2	Yes
25366	CHEMBL392688	C27H32F2N4O2	482.576	6 / 0	3.3	Yes
25416	CHEMBL468348	C24H25N3O3S2	467.602	6 / 1	4.7	Yes
25485	CHEMBL165456	C39H47N5O2	617.838	3 / 4	6.8	No
25549	CHEMBL267862	C66H99N19O13	1366.64	18 / 16	0.7	No
25599	CHEMBL415279	C50H50F2N8O6	896.997	11 / 3	5.9	No
548172	Vantas	C70H94N18O16	1443.63	19 / 17	N/A	No
26130	CHEMBL313004	C44H58N4O	658.975	3 / 2	9.7	No
26403	goserelin	C59H84N18O14	1269.43	16 / 17	-1.5	No
26465	CHEMBL115965	C26H30F3N3O3	489.539	7 / 1	4.4	Yes
26797	CHEMBL384898	C82H108ClN17O15	1607.32	18 / 17	2.8	No
26798	CHEMBL2370890	C82H108ClN17O15	1607.32	18 / 16	2.4	No
459454	UNII-7CDW97HUEX	C22H15F3N2O7S	508.424	11 / 2	3.4	No
27547	CHEMBL1766108	C29H30ClN5O2	516.042	6 / 2	5.4	No
27867	CHEMBL342396	C31H31ClF3N5O5	646.064	11 / 4	N/A	No
28328	CHEMBL342908	C35H38ClF3N4O5	687.157	10 / 4	N/A	No
28481	CHEMBL111933	C29H28F3N3O3	523.556	7 / 1	4.7	No
28499	CHEMBL23900	C29H30F2N4O3	520.581	7 / 0	4.0	No
29936	CHEMBL197317	C26H35N7O5S	557.67	8 / 4	2.7	No
31012	CHEMBL324654	C38H48N4O2	592.828	3 / 2	6.5	No

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