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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Gonadotropin-releasing hormone receptor
Species	Homo sapiens (Human)
Gene	GNRHR
Synonym	LHRHR GnRH I receptor Type I GnRHR gnRH receptor GnRH-R LHRH receptor GnRHR GNRHR1 luteinizing hormone-releasing hormone (LHRH) receptor luliberin receptor GnRH1 receptor [ Show all ]
Disease	Uterine leiomyoma Hypothalamic hypogonadism Ovulation Prostate cancer Prostate disease Prostate hyperplasia Unspecified Female infertility Esophageal cancer Endometriosis Controlled ovarian stimulation Cancer Advanced prostate cancer Acute lymphoblastic leukemia Hormone deficiency [ Show all ]
Length	328
Amino acid sequence	MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKLQKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYLKLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRMIHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTRVLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRLSDPVNHFFFLFAFLNPCFDPLIYGYFSL
UniProt	P30968
Protein Data Bank	N/A
GPCR-HGmod model	P30968
3D structure model	This predicted structure model is from GPCR-EXP P30968.
BioLiP	N/A
Therapeutic Target Database	T12475
ChEMBL	CHEMBL1855
IUPHAR	256
DrugBank	BE0000203

Ligand

Name	CHEMBL299348
Molecular formula	C34H36FN5O4
IUPAC name	methyl 2-[8-[(2-fluorophenyl)methyl]-6-(3-methoxyphenyl)-7-methyl-3-[[methyl(pyridin-2-ylmethyl)amino]methyl]-5-oxoimidazo[1,2-a]pyrimidin-2-yl]-2-methylpropanoate
Molecular weight	597.691
Hydrogen bond acceptor	9
Hydrogen bond donor	0
XlogP	4.9
Synonyms	BDBM50127179 2-{8-(2-Fluoro-benzyl)-6-(3-methoxy-phenyl)-7-methyl-3-[(methyl-pyridin-2-ylmethyl-amino)-methyl]-5-oxo-5,8-dihydro-imidazo[1,2-a]pyrimidin-2-yl}-2-methyl-propionic acid methyl ester
Inchi Key	ARQIDWVNKFKBSP-UHFFFAOYSA-N
Inchi ID	InChI=1S/C34H36FN5O4/c1-22-29(23-13-11-15-26(18-23)43-5)31(41)40-28(21-38(4)20-25-14-9-10-17-36-25)30(34(2,3)32(42)44-6)37-33(40)39(22)19-24-12-7-8-16-27(24)35/h7-18H,19-21H2,1-6H3
PubChem CID	10995569
ChEMBL	CHEMBL299348
IUPHAR	N/A
BindingDB	50127179
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
Ki	4.2 nM	PMID12699396	BindingDB,ChEMBL

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