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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Gonadotropin-releasing hormone receptor
Species	Homo sapiens (Human)
Gene	GNRHR
Synonym	LHRHR GnRH I receptor Type I GnRHR gnRH receptor GnRH-R LHRH receptor GnRHR GNRHR1 luteinizing hormone-releasing hormone (LHRH) receptor luliberin receptor GnRH1 receptor [ Show all ]
Disease	Uterine leiomyoma Hypothalamic hypogonadism Ovulation Prostate cancer Prostate disease Prostate hyperplasia Unspecified Female infertility Esophageal cancer Endometriosis Controlled ovarian stimulation Cancer Advanced prostate cancer Acute lymphoblastic leukemia Hormone deficiency [ Show all ]
Length	328
Amino acid sequence	MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKLQKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYLKLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRMIHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTRVLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRLSDPVNHFFFLFAFLNPCFDPLIYGYFSL
UniProt	P30968
Protein Data Bank	N/A
GPCR-HGmod model	P30968
3D structure model	This predicted structure model is from GPCR-EXP P30968.
BioLiP	N/A
Therapeutic Target Database	T12475
ChEMBL	CHEMBL1855
IUPHAR	256
DrugBank	BE0000203

Ligand

Name	CHEMBL71793
Molecular formula	C36H40FN5O5
IUPAC name	pentan-3-yl 2-[4-(butanoylamino)phenyl]-8-[(2-fluorophenyl)methyl]-3-[[furan-2-ylmethyl(methyl)amino]methyl]-5-oxoimidazo[1,2-a]pyrimidine-6-carboxylate
Molecular weight	641.744
Hydrogen bond acceptor	9
Hydrogen bond donor	1
XlogP	5.9
Synonyms	2-(4-Butyrylamino-phenyl)-8-(2-fluoro-benzyl)-3-[(furan-2-ylmethyl-methyl-amino)-methyl]-5-oxo-5,8-dihydro-imidazo[1,2-a]pyrimidine-6-carboxylic acid 1-ethyl-propyl ester BDBM50116218 2-[4-(Butyrylamino)phenyl]-3-[methyl(2-furylmethyl)aminomethyl]-5-oxo-8-(2-fluorobenzyl)-5,8-dihydroimidazo[1,2-a]pyrimidine-6-carboxylic acid 1-ethylpropyl ester
Inchi Key	AJSJTPARXRHMIG-UHFFFAOYSA-N
Inchi ID	InChI=1S/C36H40FN5O5/c1-5-11-32(43)38-26-17-15-24(16-18-26)33-31(23-40(4)21-28-13-10-19-46-28)42-34(44)29(35(45)47-27(6-2)7-3)22-41(36(42)39-33)20-25-12-8-9-14-30(25)37/h8-10,12-19,22,27H,5-7,11,20-21,23H2,1-4H3,(H,38,43)
PubChem CID	44309585
ChEMBL	CHEMBL71793
IUPHAR	N/A
BindingDB	50116218
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Ki	29.0 nM	PMID12127532	BindingDB,ChEMBL

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