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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Gonadotropin-releasing hormone receptor
Species	Homo sapiens (Human)
Gene	GNRHR
Synonym	LHRHR GnRH I receptor Type I GnRHR gnRH receptor GnRH-R LHRH receptor GnRHR GNRHR1 luteinizing hormone-releasing hormone (LHRH) receptor luliberin receptor GnRH1 receptor [ Show all ]
Disease	Uterine leiomyoma Hypothalamic hypogonadism Ovulation Prostate cancer Prostate disease Prostate hyperplasia Unspecified Female infertility Esophageal cancer Endometriosis Controlled ovarian stimulation Cancer Advanced prostate cancer Acute lymphoblastic leukemia Hormone deficiency [ Show all ]
Length	328
Amino acid sequence	MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKLQKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYLKLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRMIHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTRVLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRLSDPVNHFFFLFAFLNPCFDPLIYGYFSL
UniProt	P30968
Protein Data Bank	N/A
GPCR-HGmod model	P30968
3D structure model	This predicted structure model is from GPCR-EXP P30968.
BioLiP	N/A
Therapeutic Target Database	T12475
ChEMBL	CHEMBL1855
IUPHAR	256
DrugBank	BE0000203

Ligand

Name	CHEMBL392604
Molecular formula	C31H31Cl2F2N5O2
IUPAC name	6-[(3,4-dichlorophenyl)methyl]-1-[(2,6-difluorophenyl)methyl]-3-[2-[methyl(2-pyridin-2-ylethyl)amino]ethyl]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-2,4-dione
Molecular weight	614.519
Hydrogen bond acceptor	7
Hydrogen bond donor	0
XlogP	4.7
Synonyms	BDBM50215222 1-(2,6-difluorobenzyl)-6-(3,4-dichlorobenzyl)-3-(2-(methyl(2-(pyridin-2-yl)ethyl)amino)ethyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione
Inchi Key	AKKQMPVUZWTXBG-UHFFFAOYSA-N
Inchi ID	InChI=1S/C31H31Cl2F2N5O2/c1-37(13-10-22-5-2-3-12-36-22)15-16-39-30(41)24-19-38(18-21-8-9-25(32)26(33)17-21)14-11-29(24)40(31(39)42)20-23-27(34)6-4-7-28(23)35/h2-9,12,17H,10-11,13-16,18-20H2,1H3
PubChem CID	44435985
ChEMBL	CHEMBL392604
IUPHAR	N/A
BindingDB	50215222
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
Ki	255.0 nM	PMID17561404	BindingDB,ChEMBL

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