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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Gonadotropin-releasing hormone receptor
Species	Homo sapiens (Human)
Gene	GNRHR
Synonym	LHRHR GnRH I receptor Type I GnRHR gnRH receptor GnRH-R LHRH receptor GnRHR GNRHR1 luteinizing hormone-releasing hormone (LHRH) receptor luliberin receptor GnRH1 receptor [ Show all ]
Disease	Uterine leiomyoma Hypothalamic hypogonadism Ovulation Prostate cancer Prostate disease Prostate hyperplasia Unspecified Female infertility Esophageal cancer Endometriosis Controlled ovarian stimulation Cancer Advanced prostate cancer Acute lymphoblastic leukemia Hormone deficiency [ Show all ]
Length	328
Amino acid sequence	MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKLQKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYLKLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRMIHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTRVLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRLSDPVNHFFFLFAFLNPCFDPLIYGYFSL
UniProt	P30968
Protein Data Bank	N/A
GPCR-HGmod model	P30968
3D structure model	This predicted structure model is from GPCR-EXP P30968.
BioLiP	N/A
Therapeutic Target Database	T12475
ChEMBL	CHEMBL1855
IUPHAR	256
DrugBank	BE0000203

Ligand

Name	CHEMBL301103
Molecular formula	C31H37FN4O5
IUPAC name	methyl 2-[8-[(2-fluorophenyl)methyl]-3-[[2-methoxyethyl(methyl)amino]methyl]-6-(3-methoxyphenyl)-7-methyl-5-oxoimidazo[1,2-a]pyrimidin-2-yl]-2-methylpropanoate
Molecular weight	564.658
Hydrogen bond acceptor	9
Hydrogen bond donor	0
XlogP	4.3
Synonyms	BDBM50127197 2-[8-(2-Fluoro-benzyl)-3-{[(2-methoxy-ethyl)-methyl-amino]-methyl}-6-(3-methoxy-phenyl)-7-methyl-5-oxo-5,8-dihydro-imidazo[1,2-a]pyrimidin-2-yl]-2-methyl-propionic acid methyl ester
Inchi Key	AXEKRUVFUPEUSM-UHFFFAOYSA-N
Inchi ID	InChI=1S/C31H37FN4O5/c1-20-26(21-12-10-13-23(17-21)40-6)28(37)36-25(19-34(4)15-16-39-5)27(31(2,3)29(38)41-7)33-30(36)35(20)18-22-11-8-9-14-24(22)32/h8-14,17H,15-16,18-19H2,1-7H3
PubChem CID	10929801
ChEMBL	CHEMBL301103
IUPHAR	N/A
BindingDB	50127197
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
Ki	300.0 nM	PMID12699396	BindingDB,ChEMBL

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