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Check the ligand table for details.
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Ligand

Name	Prostaglandin E2
Molecular formula	C20H32O5
IUPAC name	(Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxocyclopentyl]hept-5-enoic acid
Molecular weight	352.471
Hydrogen bond acceptor	5
Hydrogen bond donor	3
XlogP	2.8
Synonyms	1798-EP2311453A1 SR-05000001459-4 HMS3402K12 XEYBRNLFEZDVAW-ARSRFYASSA-N l-Prostaglandin E2 7-(3-Hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl)-5-heptenoic acid NCGC00092361-02 alpha, Prostaglandin E2 NSC-196514 BRD-K26521938-001-04-9 Prepidil Cerviprime (5Z,11-alpha,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dien-1-oic acid Prosta-5, 11,15-dihydroxy-9-oxo-, (5Z,11.alpha.,13E,15S)- DB00917 (5Z,13E)-(15S)-11alpha,15-Dihydroxy-9-oxoprost-13-enoate Dinoprostone [USAN:INN:BAN:JAN] (E,2R,3R)-7-[3-hydroxy-2-[(3S)-(3-hydroxy-1-octenyl)]-5-oxocyclopentyl]-5-heptenoic acid Prostaglandin,PGE2 DSSTox_RID_76801 1798-EP2277858A1 RP17686 Gel, Prepidil HMS1361K12 1798-EP2314574A1 U 12062 IDI1_033960 5-Heptenoic acid, 7-(3-hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl)- [3H]dinoprostone MFCD00077861 AC-6098 NCGC00092361-05 BC219642 P1884 CAS-363-24-6 Prepidil Gel CHEMBL548 (5Z,11alpha,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dien-1-oic Prosta-5,13-dien-1-oic acid, 11,15-dihydroxy-9-oxo-, (5Z,11.alpha.,13E,15S)- Dinoprostona [INN-Spanish] (5Z,13E)-(15S)-11alpha,15-Dihydroxy-9-oxoprosta-5,13-dienoic acid Prostaglandin E2, >=93% (HPLC), synthetic Dinoprostone, United States Pharmacopeia (USP) Reference Standard (Z)-7-[(1r,2r,3r)-3-Hydroxy-2-[(E,3s)-3-Hydroxyoct-1-Enyl]-5-Oxo-Cyclopentyl]hept-5-Enoic Acid Prostenone E2, Prostaglandin 1798-EP2301922A1 SR-01000946417 SR-05000001459-1 HMS2089D17 U-12062 l-7-(3-Hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl)-5-heptenoic acid 5-Heptenoic acid, 7-(3-hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl)-, l- [3H]prostin E2 MolPort-003-939-184 AKOS015920228 NSC 196514 BMS-279654 & PGE2 PGE2 alpha Cervidil (-)-Prostaglandin E2 Propess (TN) D06FEA (5Z,11I+/-,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dienoic acid Prostaglandin E Dinoprostone beta-Cyclodextrin Clathrate (5Z,13E,15S)-11-alpha,15-dihydroxy-9-oxoprost-5,13-dienoic acid Prostaglandin E2.alpha. DSSTox_CID_2947 1798-EP2272832A1 Prostin E2 Enzaprost E 1798-EP2308510A1 1798-EP2311808A1 Tox21_111196 HMS3648F07 363-24-6 ZINC3830713 LMFA03010003 7-[3-Hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl]-5-heptenoic acid NCGC00092361-03 AN-10387 NSC165560 BSPBio_001490 CHEBI:15551 (5Z,11.alpha.,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dien-1-oic acid Prosta-5, 11,5-dihydroxy-9-oxo-, (5Z,11.alpha.,13E,15S)- Dinoproston (5Z,13E)-(15S)-11alpha,15-Dihydroxy-9-oxoprost-13-enoic acid Prostaglandin E2 alpha Dinoprostone [USAN:USP:INN:BAN:JAN] (E,Z)-(1R,2R,3R)-7-(3-Hydroxy-2-((3S)-(3-hydroxy-1-octenyl))-5-oxocyclopentyl)-5-heptenoic acid Prostarmon E DTXSID4022947 1798-EP2295055A2 SCHEMBL25533 GTPL1883 HMS1791K12 1798-EP2314587A1 U,062 J-502620 5-Heptenoic acid, 7-(3-hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl)- (8CI) [3H]PGE2 Minprositin E2 AC1NQWXW NCGC00092361-06 BDBM35847 P2E CCG-208092 Prestwick_793 CS-6932 (5Z,11alpha,13E,15S)-11,15-dihydroxy-9-oxoprosta-5,13-dien-1-oic acid Prosta-5,13-dien-1-oic acid, 11,15-dihydroxy-9-oxo-, (5Z,11alpha,13E,15S)- Dinoprostone (5Z,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dien-1-oic acid Prostaglandin E2, gamma-irradiated, powder, BioXtra, suitable for cell culture Dinoprostonum (Z)-7-[(1R,2R,3R)-3-Hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxocyclopentyl]hept-5-enoic acid Prostin E2alpha, Prostaglandin 1798-EP2305641A1 SR-01000946417-1 1798-EP2308872A1 SR-05000001459-3 HMS3268J12 UNII-K7Q1JQR04M l-PGE2 5-Heptenoic acid, 7-[3-hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl]- NCGC00092361-01 alpha, PGE2 NSC-165560 BR-72815 PGE2alpha Cervidil (TN) (15S)-Prostaglandin E2 Prosta-5, (5Z,11.alpha.,13E,15S)-11,15-dihydroxy-9-oxo- (5Z,11\|A,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dienoic acid Prostaglandin E(2) Dinoprostone Prostaglandin E2 (5Z,13E,15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dien-1-oic acid Prostaglandin E2alpha DSSTox_GSID_22947 1798-EP2277848A1 Prostin E2 (TN) EX-A1773 1798-EP2311829A1 Tox21_111196_1 HY-101952 363P246 [3H]-PGE2 LS-125823 9-oxo-11R,15S-dihydroxy-5Z,13E-prostadienoic acid NCGC00092361-04 B7005 NSC196514 C00584 Prepidil (TN) (5Z,11?,13E,15S)-11,15-Dihydroxy-9-oxo-prosta-5,13-dien-1oic acid Prosta-5,13-dien-1-oic acid, (5Z,11-alpha,13E,15S)-11,15-dihydroxy-9-oxo- Dinoprostona (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate Prostaglandin E2, 98% Dinoprostone, European Pharmacopoeia (EP) Reference Standard (Z)-7-((1R,2R,3R)-3-Hydroxy-2-((S,E)-3-hydroxyoct-1-en-1-yl)-5-oxocyclopentyl)hept-5-enoic acid Prostarmon E2 E2 alpha, Prostaglandin 1798-EP2298767A1 SMP2_000056 GTPL1916 HMS1989K12 1798-EP2316829A1 U-12,062 K7Q1JQR04M 5-Heptenoic acid, 7-(3-hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl)-(8CI) [3H]prostaglandin E2 Minprostin E2 AJ-45765 NSC 165560 BML1-F07 PGE2 CCG-208256 Propess D00079 (5Z,11alpha,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dienoic acid prosta-glandin e2 Dinoprostone (JAN/USP/INN) (5Z,13E,15S)-11-alpha,15-dihydroxy-9-oxoprost-5,13-dienoate Prostaglandin E2, synthetic, powder, BioReagent, suitable for cell culture Dinoprostonum [INN-Latin] 05D31BD5-818B-4A92-8CFC-BEC19926A5B3 Prostin E EINECS 206-656-6 1798-EP2305653A1 SR-05000001459 [ Show all ]
Inchi Key	XEYBRNLFEZDVAW-ARSRFYASSA-N
Inchi ID	InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1
PubChem CID	5280360
ChEMBL	CHEMBL548
IUPHAR	1883, 1916
BindingDB	35847
DrugBank	DB00917
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
390109	Prostacyclin receptor	P43119	PTGIR	Homo sapiens (Human)	386
390106	Prostaglandin D2 receptor	Q9R261	Ptgdr	Rattus norvegicus (Rat)	357
555251	Prostaglandin D2 receptor	Q13258	PTGDR	Homo sapiens (Human)	359
390117	Prostaglandin D2 receptor 2	Q9Y5Y4	PTGDR2	Homo sapiens (Human)	395
555247	Prostaglandin D2 receptor 2	Q9Z2J6	Ptgdr2	Mus musculus (Mouse)	382
390098	Prostaglandin E2 receptor EP1 subtype	P34995	PTGER1	Homo sapiens (Human)	402
390107	Prostaglandin E2 receptor EP1 subtype	P35375	Ptger1	Mus musculus (Mouse)	405
555249	Prostaglandin E2 receptor EP1 subtype	P70597	Ptger1	Rattus norvegicus (Rat)	405
390099	Prostaglandin E2 receptor EP2 subtype	Q62053	Ptger2	Mus musculus (Mouse)	362
390101	Prostaglandin E2 receptor EP2 subtype	Q62928	Ptger2	Rattus norvegicus (Rat)	357
390102	Prostaglandin E2 receptor EP2 subtype	P43116	PTGER2	Homo sapiens (Human)	358
390104	Prostaglandin E2 receptor EP3 subtype	P30557	Ptger3	Mus musculus (Mouse)	365
390105	Prostaglandin E2 receptor EP3 subtype	P43115	PTGER3	Homo sapiens (Human)	390
555248	Prostaglandin E2 receptor EP3 subtype	P34980	Ptger3	Rattus norvegicus (Rat)	365
390097	Prostaglandin E2 receptor EP4 subtype	P35408	PTGER4	Homo sapiens (Human)	488
390111	Prostaglandin E2 receptor EP4 subtype	P43114	Ptger4	Rattus norvegicus (Rat)	488
390116	Prostaglandin E2 receptor EP4 subtype	P32240	Ptger4	Mus musculus (Mouse)	513
390100	Prostaglandin F2-alpha receptor	P43117	Ptgfr	Mus musculus (Mouse)	366
390108	Prostaglandin F2-alpha receptor	P43088	PTGFR	Homo sapiens (Human)	359
390112	Prostaglandin F2-alpha receptor	P37289	PTGFR	Bos taurus (Bovine)	362

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