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GPCR

Name	Prostaglandin E2 receptor EP4 subtype
Species	Homo sapiens (Human)
Gene	PTGER4
Synonym	Prostanoid EP4 receptor PGE2 receptor EP4 subtype PGE receptor EP4 subtype EP4 receptor EP2
Disease	Ulcerative colitis Glaucoma Inflammatory disease Migraine Osteoarthritis Osteoarthritis; Pain Pain Fracture Asthma Acute heart failure [ Show all ]
Length	488
Amino acid sequence	MSTPGVNSSASLSPDRLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGGQPLCEYSTFILLFFSLSGLSIICAMSVERYLAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGSSRLQYPDTWCFIDWTTNVTAHAAYSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAAAAASVASRGHPAASPALPRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFVNQLYQPSLEREVSKNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSRRERSGQHCSDSQRTSSAMSGHSRSFISRELKEISSTSQTLLPDLSLPDLSENGLGGRNLLPGVPGMGLAQEDTTSLRTLRISETSDSSQGQDSESVLLVDEAGGSGRAGPAPKGSSLQVTFPSETLNLSEKCI
UniProt	P35408
Protein Data Bank	5ywy, 5yhl
GPCR-HGmod model	P35408
3D structure model	This structure is from PDB ID 5ywy.
BioLiP	BL0434347, BL0434289
Therapeutic Target Database	T18876
ChEMBL	CHEMBL1836
IUPHAR	343
DrugBank	BE0003522

Ligand

Name	Prostaglandin E2
Molecular formula	C20H32O5
IUPAC name	(Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxocyclopentyl]hept-5-enoic acid
Molecular weight	352.471
Hydrogen bond acceptor	5
Hydrogen bond donor	3
XlogP	2.8
Synonyms	Dinoprostone, United States Pharmacopeia (USP) Reference Standard (Z)-7-[(1r,2r,3r)-3-Hydroxy-2-[(E,3s)-3-Hydroxyoct-1-Enyl]-5-Oxo-Cyclopentyl]hept-5-Enoic Acid E2, Prostaglandin 1798-EP2301922A1 HMS1361K12 1798-EP2314574A1 IDI1_033960 5-Heptenoic acid, 7-(3-hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl)- MFCD00077861 AC-6098 NCGC00092361-05 BC219642 P1884 CAS-363-24-6 CHEMBL548 (5Z,11alpha,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dien-1-oic Dinoprostona [INN-Spanish] (5Z,13E)-(15S)-11alpha,15-Dihydroxy-9-oxoprosta-5,13-dienoic acid Prosta-5, 11,5-dihydroxy-9-oxo-, (5Z,11.alpha.,13E,15S)- Prostaglandin E2 alpha Prostarmon E SCHEMBL25533 Tox21_111196 ZINC3830713 DSSTox_CID_2947 1798-EP2272832A1 Enzaprost E 1798-EP2308510A1 HMS2089D17 l-7-(3-Hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl)-5-heptenoic acid 5-Heptenoic acid, 7-(3-hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl)-, l- MolPort-003-939-184 AKOS015920228 NSC 196514 BMS-279654 & PGE2 PGE2 alpha Cervidil (-)-Prostaglandin E2 D06FEA (5Z,11I+/-,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dienoic acid Dinoprostone beta-Cyclodextrin Clathrate (5Z,13E,15S)-11-alpha,15-dihydroxy-9-oxoprost-5,13-dienoic acid Prestwick_793 Prosta-5,13-dien-1-oic acid, 11,15-dihydroxy-9-oxo-, (5Z,11alpha,13E,15S)- Prostaglandin E2, gamma-irradiated, powder, BioXtra, suitable for cell culture Prostin SR-01000946417-1 U,062 [3H]PGE2 (E,Z)-(1R,2R,3R)-7-(3-Hydroxy-2-((3S)-(3-hydroxy-1-octenyl))-5-oxocyclopentyl)-5-heptenoic acid DTXSID4022947 1798-EP2295055A2 GTPL1883 1798-EP2311808A1 HMS3648F07 363-24-6 LMFA03010003 7-[3-Hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl]-5-heptenoic acid NCGC00092361-03 AN-10387 NSC165560 BSPBio_001490 CHEBI:15551 (5Z,11.alpha.,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dien-1-oic acid Dinoproston (5Z,13E)-(15S)-11alpha,15-Dihydroxy-9-oxoprost-13-enoic acid Dinoprostone [USAN:USP:INN:BAN:JAN] Prosta-5, (5Z,11.alpha.,13E,15S)-11,15-dihydroxy-9-oxo- Prostaglandin E(2) Prostaglandin E2alpha Prostin E2 (TN) SR-05000001459-3 UNII-K7Q1JQR04M Dinoprostonum (Z)-7-[(1R,2R,3R)-3-Hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxocyclopentyl]hept-5-enoic acid E2alpha, Prostaglandin 1798-EP2305641A1 HMS1791K12 1798-EP2314587A1 J-502620 5-Heptenoic acid, 7-(3-hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl)- (8CI) Minprositin E2 AC1NQWXW NCGC00092361-06 BDBM35847 P2E CCG-208092 CS-6932 (5Z,11alpha,13E,15S)-11,15-dihydroxy-9-oxoprosta-5,13-dien-1-oic acid Dinoprostone (5Z,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dien-1-oic acid Prepidil (TN) Prosta-5,13-dien-1-oic acid, (5Z,11-alpha,13E,15S)-11,15-dihydroxy-9-oxo- Prostaglandin E2, 98% Prostarmon E2 SMP2_000056 Tox21_111196_1 [3H]-PGE2 (5Z,13E,15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dien-1-oic acid DSSTox_GSID_22947 1798-EP2277848A1 EX-A1773 1798-EP2308872A1 HMS3268J12 l-PGE2 5-Heptenoic acid, 7-[3-hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl]- NCGC00092361-01 alpha, PGE2 NSC-165560 BR-72815 PGE2alpha Cervidil (TN) (15S)-Prostaglandin E2 (5Z,11\|A,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dienoic acid Dinoprostone Prostaglandin E2 Propess prosta-glandin e2 Prostaglandin E2, synthetic, powder, BioReagent, suitable for cell culture Prostin E SR-05000001459 U-12,062 [3H]prostaglandin E2 (Z)-7-((1R,2R,3R)-3-Hydroxy-2-((S,E)-3-hydroxyoct-1-en-1-yl)-5-oxocyclopentyl)hept-5-enoic acid E2 alpha, Prostaglandin 1798-EP2298767A1 GTPL1916 1798-EP2311829A1 HY-101952 363P246 LS-125823 9-oxo-11R,15S-dihydroxy-5Z,13E-prostadienoic acid NCGC00092361-04 B7005 NSC196514 C00584 (5Z,11?,13E,15S)-11,15-Dihydroxy-9-oxo-prosta-5,13-dien-1oic acid Dinoprostona (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate Dinoprostone, European Pharmacopoeia (EP) Reference Standard Prosta-5, 11,15-dihydroxy-9-oxo-, (5Z,11.alpha.,13E,15S)- Prostaglandin,PGE2 RP17686 SR-05000001459-4 XEYBRNLFEZDVAW-ARSRFYASSA-N Dinoprostonum [INN-Latin] 05D31BD5-818B-4A92-8CFC-BEC19926A5B3 EINECS 206-656-6 1798-EP2305653A1 HMS1989K12 1798-EP2316829A1 K7Q1JQR04M 5-Heptenoic acid, 7-(3-hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl)-(8CI) Minprostin E2 AJ-45765 NSC 165560 BML1-F07 PGE2 CCG-208256 D00079 (5Z,11alpha,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dienoic acid Dinoprostone (JAN/USP/INN) (5Z,13E,15S)-11-alpha,15-dihydroxy-9-oxoprost-5,13-dienoate Prepidil Gel Prosta-5,13-dien-1-oic acid, 11,15-dihydroxy-9-oxo-, (5Z,11.alpha.,13E,15S)- Prostaglandin E2, >=93% (HPLC), synthetic Prostenone SR-01000946417 U 12062 [3H]dinoprostone (E,2R,3R)-7-[3-hydroxy-2-[(3S)-(3-hydroxy-1-octenyl)]-5-oxocyclopentyl]-5-heptenoic acid DSSTox_RID_76801 1798-EP2277858A1 Gel, Prepidil 1798-EP2311453A1 HMS3402K12 l-Prostaglandin E2 7-(3-Hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl)-5-heptenoic acid NCGC00092361-02 alpha, Prostaglandin E2 NSC-196514 BRD-K26521938-001-04-9 Prepidil Cerviprime (5Z,11-alpha,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dien-1-oic acid DB00917 (5Z,13E)-(15S)-11alpha,15-Dihydroxy-9-oxoprost-13-enoate Dinoprostone [USAN:INN:BAN:JAN] Propess (TN) Prostaglandin E Prostaglandin E2.alpha. Prostin E2 SR-05000001459-1 U-12062 [3H]prostin E2 [ Show all ]
Inchi Key	XEYBRNLFEZDVAW-ARSRFYASSA-N
Inchi ID	InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1
PubChem CID	5280360
ChEMBL	CHEMBL548
IUPHAR	1883, 1916
BindingDB	35847
DrugBank	DB00917
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
	N/A	N/A	DrugBank
Activity	40.0 %	PMID24279689	ChEMBL
EC50	3.0 nM	PMID12643927, PMID18039575	BindingDB,ChEMBL
EC50	7.5 nM	PMID26985320	BindingDB,ChEMBL
EC50	900.0 nM	PMID19584306	IUPHAR
IC50	0.45 nM	PMID23466604	ChEMBL
IC50	0.55 nM	PMID27876250	ChEMBL
IC50	0.7 nM	PMID12643927	BindingDB
IC50	0.7 nM	PMID12643927	ChEMBL
IC50	1.1 nM	PMID23403082	ChEMBL
IC50	3.8 nM	PMID18983139	ChEMBL
IC50	5.5 nM	PMID27876250	BindingDB
IC50	9.9 nM	PMID20218623	BindingDB,ChEMBL
Inhibition	5.0 %	PMID23403082	ChEMBL
Kd	0.3 - 24.0 nM	PMID16604093, PMID10634944, PMID10952683, PMID22480736	IUPHAR
Ki	0.17 nM	PMID23466604	ChEMBL
Ki	0.45 nM	PMID23403082	ChEMBL
Ki	0.79 nM	PMID18039575, PMID17931866, PMID10634944, PMID17531488	BindingDB,ChEMBL
Ki	0.794 - 7.94 nM	PMID16604093, PMID10634944, PMID10462542, PMID10952683, PMID17495127	IUPHAR
Ki	1.9 nM	PMID18983139	ChEMBL
Ki	3.1 nM	PMID24279689	BindingDB,ChEMBL

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