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GPCR

Name	Prostaglandin D2 receptor
Species	Rattus norvegicus (Rat)
Gene	Ptgdr
Synonym	DP1 receptor PGD receptor PGD2 receptor DP1 prostaglandin D2 receptor (DP) Prostanoid DP receptor prostanoid DP receptor-like PTGDR1 [ Show all ]
Disease	N/A for non-human GPCRs
Length	357
Amino acid sequence	MNESYRCQAATWVERGSSATMGGVAFSAGLLGNLLALVLLARSGLGSCRPGPLHPPPSVFYVLVCGLTVTDLLGKCLISPMVLAAYAQNRSLKELLPASGNQLCEAFAFLMSFFGLASTLQLLAMALECWLSLGHPFFYQRHITARRGVLVAPVAGAFSLAFCALPFAGFGKFVQYCPGTWCFIQMIHKKRSFSVIGFSVLYSSLMALLVLATVVCNLGAMSNLYAMHRRQRHHPRRCSRDRAQSGSDYRHGSPNPLEELDHFVLLALTTVLFTMCSLPLIYRAYYGAFKLVDRADGDSEDLQALRFLSVISIVDPWIFIIFRTSVFRMLFHKTFTRPLIYRNWCSHSWQTNMESTL
UniProt	Q9R261
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	N/A
IUPHAR	338
DrugBank	N/A

Ligand

Name	Prostaglandin E2
Molecular formula	C20H32O5
IUPAC name	(Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxocyclopentyl]hept-5-enoic acid
Molecular weight	352.471
Hydrogen bond acceptor	5
Hydrogen bond donor	3
XlogP	2.8
Synonyms	Prepidil Gel (5Z,13E,15S)-11-alpha,15-dihydroxy-9-oxoprost-5,13-dienoate Dinoprostonum [INN-Latin] Prosta-5,13-dien-1-oic acid, 11,15-dihydroxy-9-oxo-, (5Z,11.alpha.,13E,15S)- 05D31BD5-818B-4A92-8CFC-BEC19926A5B3 EINECS 206-656-6 Prostaglandin E2, >=93% (HPLC), synthetic 1798-EP2305653A1 HMS1989K12 Prostenone 1798-EP2316829A1 K7Q1JQR04M SR-01000946417 5-Heptenoic acid, 7-(3-hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl)-(8CI) Minprostin E2 U 12062 AJ-45765 NSC 165560 [3H]dinoprostone BML1-F07 PGE2 CCG-208256 D00079 (5Z,11alpha,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dienoic acid Dinoprostone (JAN/USP/INN) Dinoprostone [USAN:INN:BAN:JAN] Propess (TN) (E,2R,3R)-7-[3-hydroxy-2-[(3S)-(3-hydroxy-1-octenyl)]-5-oxocyclopentyl]-5-heptenoic acid DSSTox_RID_76801 Prostaglandin E 1798-EP2277858A1 Gel, Prepidil Prostaglandin E2.alpha. 1798-EP2311453A1 HMS3402K12 Prostin E2 l-Prostaglandin E2 SR-05000001459-1 7-(3-Hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl)-5-heptenoic acid NCGC00092361-02 U-12062 alpha, Prostaglandin E2 NSC-196514 [3H]prostin E2 BRD-K26521938-001-04-9 Prepidil Cerviprime (5Z,11-alpha,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dien-1-oic acid DB00917 (5Z,13E)-(15S)-11alpha,15-Dihydroxy-9-oxoprost-13-enoate (5Z,13E)-(15S)-11alpha,15-Dihydroxy-9-oxoprosta-5,13-dienoic acid Dinoprostone, United States Pharmacopeia (USP) Reference Standard Prosta-5, 11,5-dihydroxy-9-oxo-, (5Z,11.alpha.,13E,15S)- (Z)-7-[(1r,2r,3r)-3-Hydroxy-2-[(E,3s)-3-Hydroxyoct-1-Enyl]-5-Oxo-Cyclopentyl]hept-5-Enoic Acid E2, Prostaglandin Prostaglandin E2 alpha 1798-EP2301922A1 HMS1361K12 Prostarmon E 1798-EP2314574A1 IDI1_033960 SCHEMBL25533 5-Heptenoic acid, 7-(3-hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl)- MFCD00077861 Tox21_111196 AC-6098 NCGC00092361-05 ZINC3830713 BC219642 P1884 CAS-363-24-6 CHEMBL548 (5Z,11alpha,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dien-1-oic Dinoprostona [INN-Spanish] Prestwick_793 (5Z,13E,15S)-11-alpha,15-dihydroxy-9-oxoprost-5,13-dienoic acid DSSTox_CID_2947 Prosta-5,13-dien-1-oic acid, 11,15-dihydroxy-9-oxo-, (5Z,11alpha,13E,15S)- 1798-EP2272832A1 Enzaprost E Prostaglandin E2, gamma-irradiated, powder, BioXtra, suitable for cell culture 1798-EP2308510A1 HMS2089D17 Prostin l-7-(3-Hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl)-5-heptenoic acid SR-01000946417-1 5-Heptenoic acid, 7-(3-hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl)-, l- MolPort-003-939-184 U,062 AKOS015920228 NSC 196514 [3H]PGE2 BMS-279654 & PGE2 PGE2 alpha Cervidil (-)-Prostaglandin E2 D06FEA (5Z,11I+/-,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dienoic acid Dinoprostone beta-Cyclodextrin Clathrate Dinoprostone [USAN:USP:INN:BAN:JAN] Prosta-5, (5Z,11.alpha.,13E,15S)-11,15-dihydroxy-9-oxo- (E,Z)-(1R,2R,3R)-7-(3-Hydroxy-2-((3S)-(3-hydroxy-1-octenyl))-5-oxocyclopentyl)-5-heptenoic acid DTXSID4022947 Prostaglandin E(2) 1798-EP2295055A2 GTPL1883 Prostaglandin E2alpha 1798-EP2311808A1 HMS3648F07 Prostin E2 (TN) 363-24-6 LMFA03010003 SR-05000001459-3 7-[3-Hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl]-5-heptenoic acid NCGC00092361-03 UNII-K7Q1JQR04M AN-10387 NSC165560 BSPBio_001490 CHEBI:15551 (5Z,11.alpha.,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dien-1-oic acid Dinoproston (5Z,13E)-(15S)-11alpha,15-Dihydroxy-9-oxoprost-13-enoic acid Prepidil (TN) (5Z,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dien-1-oic acid Dinoprostonum Prosta-5,13-dien-1-oic acid, (5Z,11-alpha,13E,15S)-11,15-dihydroxy-9-oxo- (Z)-7-[(1R,2R,3R)-3-Hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxocyclopentyl]hept-5-enoic acid E2alpha, Prostaglandin Prostaglandin E2, 98% 1798-EP2305641A1 HMS1791K12 Prostarmon E2 1798-EP2314587A1 J-502620 SMP2_000056 5-Heptenoic acid, 7-(3-hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl)- (8CI) Minprositin E2 Tox21_111196_1 AC1NQWXW NCGC00092361-06 [3H]-PGE2 BDBM35847 P2E CCG-208092 CS-6932 (5Z,11alpha,13E,15S)-11,15-dihydroxy-9-oxoprosta-5,13-dien-1-oic acid Dinoprostone Dinoprostone Prostaglandin E2 Propess (5Z,13E,15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dien-1-oic acid DSSTox_GSID_22947 prosta-glandin e2 1798-EP2277848A1 EX-A1773 Prostaglandin E2, synthetic, powder, BioReagent, suitable for cell culture 1798-EP2308872A1 HMS3268J12 Prostin E l-PGE2 SR-05000001459 5-Heptenoic acid, 7-[3-hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl]- NCGC00092361-01 U-12,062 alpha, PGE2 NSC-165560 [3H]prostaglandin E2 BR-72815 PGE2alpha Cervidil (TN) (15S)-Prostaglandin E2 (5Z,11\|A,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dienoic acid Dinoprostone, European Pharmacopoeia (EP) Reference Standard Prosta-5, 11,15-dihydroxy-9-oxo-, (5Z,11.alpha.,13E,15S)- (Z)-7-((1R,2R,3R)-3-Hydroxy-2-((S,E)-3-hydroxyoct-1-en-1-yl)-5-oxocyclopentyl)hept-5-enoic acid E2 alpha, Prostaglandin 1798-EP2298767A1 GTPL1916 Prostaglandin,PGE2 1798-EP2311829A1 HY-101952 RP17686 363P246 LS-125823 SR-05000001459-4 9-oxo-11R,15S-dihydroxy-5Z,13E-prostadienoic acid NCGC00092361-04 XEYBRNLFEZDVAW-ARSRFYASSA-N B7005 NSC196514 C00584 (5Z,11?,13E,15S)-11,15-Dihydroxy-9-oxo-prosta-5,13-dien-1oic acid Dinoprostona (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate [ Show all ]
Inchi Key	XEYBRNLFEZDVAW-ARSRFYASSA-N
Inchi ID	InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1
PubChem CID	5280360
ChEMBL	CHEMBL548
IUPHAR	1883, 1916
BindingDB	35847
DrugBank	DB00917
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	2948.0 nM	PMID6292197	BindingDB

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