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GPCR

Name	Prostaglandin E2 receptor EP2 subtype
Species	Rattus norvegicus (Rat)
Gene	Ptger2
Synonym	EP2 receptor PGE receptor EP2 subtype PGE2 receptor EP2 subtype prostaglandin E receptor 2 (subtype EP2), 53kDa Prostanoid EP2 receptor Ptger-ep2 [ Show all ]
Disease	N/A for non-human GPCRs
Length	357
Amino acid sequence	MDNSFNDSRRVENCESRQYLLSDESPAISSVMFTAGVLGNLIALALLARRWRGDTGCSAGSRTSISLFHVLVTELVLTDLLGTCLISPVVLASYSRNQTLVALAPESRACTYFAFTMTFFSLATMLMLFAMALERYLAIGHPYFYRRRVSRRGGLAVLPAIYGVSLLFCSLPLLNYGEYVQYCPGTWCFIQHGRTAYLQLYATVLLLLIVAVLGCNISVILNLIRMQLRSKRSRCGLSGSSLRGPGSRRRGERTSMAEETDHLILLAIMTITFAVCSLPFTIFAYMDETSSRKEKWDLRALRFLSVNSIIDPWVFVILRPPVLRLMRSVLCCRTSLRAPEAPGASCSTQQTDLCGQL
UniProt	Q62928
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4909
IUPHAR	341
DrugBank	N/A

Ligand

Name	Prostaglandin E2
Molecular formula	C20H32O5
IUPAC name	(Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxocyclopentyl]hept-5-enoic acid
Molecular weight	352.471
Hydrogen bond acceptor	5
Hydrogen bond donor	3
XlogP	2.8
Synonyms	EX-A1773 1798-EP2308872A1 Prostaglandin,PGE2 HMS3268J12 RP17686 l-PGE2 5-Heptenoic acid, 7-[3-hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl]- SR-05000001459-4 NCGC00092361-01 alpha, PGE2 XEYBRNLFEZDVAW-ARSRFYASSA-N NSC-165560 BR-72815 PGE2alpha Cervidil (TN) (15S)-Prostaglandin E2 (5Z,11\|A,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dienoic acid Dinoprostone Prostaglandin E2 (5Z,13E,15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dien-1-oic acid Prosta-5, 11,15-dihydroxy-9-oxo-, (5Z,11.alpha.,13E,15S)- DSSTox_GSID_22947 1798-EP2277848A1 Prostaglandin E2, >=93% (HPLC), synthetic GTPL1916 1798-EP2311829A1 Prostenone HY-101952 363P246 SR-01000946417 LS-125823 9-oxo-11R,15S-dihydroxy-5Z,13E-prostadienoic acid U 12062 NCGC00092361-04 B7005 [3H]dinoprostone NSC196514 C00584 (5Z,11?,13E,15S)-11,15-Dihydroxy-9-oxo-prosta-5,13-dien-1oic acid Dinoprostona (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate Prepidil Gel Dinoprostone, European Pharmacopoeia (EP) Reference Standard (Z)-7-((1R,2R,3R)-3-Hydroxy-2-((S,E)-3-hydroxyoct-1-en-1-yl)-5-oxocyclopentyl)hept-5-enoic acid Prosta-5,13-dien-1-oic acid, 11,15-dihydroxy-9-oxo-, (5Z,11.alpha.,13E,15S)- E2 alpha, Prostaglandin 1798-EP2298767A1 1798-EP2305653A1 Prostaglandin E2.alpha. HMS1989K12 1798-EP2316829A1 Prostin E2 K7Q1JQR04M 5-Heptenoic acid, 7-(3-hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl)-(8CI) SR-05000001459-1 Minprostin E2 AJ-45765 U-12062 NSC 165560 BML1-F07 [3H]prostin E2 PGE2 CCG-208256 D00079 (5Z,11alpha,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dienoic acid Dinoprostone (JAN/USP/INN) (5Z,13E,15S)-11-alpha,15-dihydroxy-9-oxoprost-5,13-dienoate Propess (TN) Dinoprostonum [INN-Latin] 05D31BD5-818B-4A92-8CFC-BEC19926A5B3 Prostaglandin E EINECS 206-656-6 Prostaglandin E2 alpha Gel, Prepidil 1798-EP2311453A1 Prostarmon E HMS3402K12 SCHEMBL25533 l-Prostaglandin E2 7-(3-Hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl)-5-heptenoic acid Tox21_111196 NCGC00092361-02 alpha, Prostaglandin E2 ZINC3830713 NSC-196514 BRD-K26521938-001-04-9 Prepidil Cerviprime (5Z,11-alpha,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dien-1-oic acid DB00917 (5Z,13E)-(15S)-11alpha,15-Dihydroxy-9-oxoprost-13-enoate Dinoprostone [USAN:INN:BAN:JAN] (E,2R,3R)-7-[3-hydroxy-2-[(3S)-(3-hydroxy-1-octenyl)]-5-oxocyclopentyl]-5-heptenoic acid Prosta-5, 11,5-dihydroxy-9-oxo-, (5Z,11.alpha.,13E,15S)- DSSTox_RID_76801 1798-EP2277858A1 1798-EP2301922A1 Prostaglandin E2, gamma-irradiated, powder, BioXtra, suitable for cell culture HMS1361K12 1798-EP2314574A1 Prostin IDI1_033960 5-Heptenoic acid, 7-(3-hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl)- SR-01000946417-1 MFCD00077861 AC-6098 U,062 NCGC00092361-05 BC219642 [3H]PGE2 P1884 CAS-363-24-6 CHEMBL548 (5Z,11alpha,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dien-1-oic Dinoprostona [INN-Spanish] (5Z,13E)-(15S)-11alpha,15-Dihydroxy-9-oxoprosta-5,13-dienoic acid Prestwick_793 Dinoprostone, United States Pharmacopeia (USP) Reference Standard (Z)-7-[(1r,2r,3r)-3-Hydroxy-2-[(E,3s)-3-Hydroxyoct-1-Enyl]-5-Oxo-Cyclopentyl]hept-5-Enoic Acid Prosta-5,13-dien-1-oic acid, 11,15-dihydroxy-9-oxo-, (5Z,11alpha,13E,15S)- E2, Prostaglandin 1798-EP2308510A1 Prostaglandin E2alpha HMS2089D17 Prostin E2 (TN) l-7-(3-Hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl)-5-heptenoic acid 5-Heptenoic acid, 7-(3-hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl)-, l- SR-05000001459-3 MolPort-003-939-184 AKOS015920228 UNII-K7Q1JQR04M NSC 196514 BMS-279654 & PGE2 PGE2 alpha Cervidil (-)-Prostaglandin E2 D06FEA (5Z,11I+/-,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dienoic acid Dinoprostone beta-Cyclodextrin Clathrate (5Z,13E,15S)-11-alpha,15-dihydroxy-9-oxoprost-5,13-dienoic acid Prosta-5, (5Z,11.alpha.,13E,15S)-11,15-dihydroxy-9-oxo- DSSTox_CID_2947 1798-EP2272832A1 Prostaglandin E(2) Enzaprost E Prostaglandin E2, 98% GTPL1883 1798-EP2311808A1 Prostarmon E2 HMS3648F07 363-24-6 SMP2_000056 LMFA03010003 7-[3-Hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl]-5-heptenoic acid Tox21_111196_1 NCGC00092361-03 AN-10387 [3H]-PGE2 NSC165560 BSPBio_001490 CHEBI:15551 (5Z,11.alpha.,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dien-1-oic acid Dinoproston (5Z,13E)-(15S)-11alpha,15-Dihydroxy-9-oxoprost-13-enoic acid Prepidil (TN) Dinoprostone [USAN:USP:INN:BAN:JAN] (E,Z)-(1R,2R,3R)-7-(3-Hydroxy-2-((3S)-(3-hydroxy-1-octenyl))-5-oxocyclopentyl)-5-heptenoic acid Prosta-5,13-dien-1-oic acid, (5Z,11-alpha,13E,15S)-11,15-dihydroxy-9-oxo- DTXSID4022947 1798-EP2295055A2 1798-EP2305641A1 Prostaglandin E2, synthetic, powder, BioReagent, suitable for cell culture HMS1791K12 1798-EP2314587A1 Prostin E J-502620 5-Heptenoic acid, 7-(3-hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl)- (8CI) SR-05000001459 Minprositin E2 AC1NQWXW U-12,062 NCGC00092361-06 BDBM35847 [3H]prostaglandin E2 P2E CCG-208092 CS-6932 (5Z,11alpha,13E,15S)-11,15-dihydroxy-9-oxoprosta-5,13-dien-1-oic acid Dinoprostone (5Z,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dien-1-oic acid Propess Dinoprostonum (Z)-7-[(1R,2R,3R)-3-Hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxocyclopentyl]hept-5-enoic acid prosta-glandin e2 E2alpha, Prostaglandin [ Show all ]
Inchi Key	XEYBRNLFEZDVAW-ARSRFYASSA-N
Inchi ID	InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1
PubChem CID	5280360
ChEMBL	CHEMBL548
IUPHAR	1916, 1883
BindingDB	35847
DrugBank	DB00917
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	0.2 nM	PMID19250823	BindingDB,ChEMBL
EC50	19.0 nM	PMID22386979	BindingDB,ChEMBL
IC50	5.2 nM	PMID19250823	BindingDB,ChEMBL
Kd	5.01187 - 15.8489 nM	PMID9537820, PMID9440134	IUPHAR
Ki	6.30957 nM	PMID9537820	IUPHAR

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