Zhang Lab

National University of Singapore

Home Research COVID-19 Services Publications People Teaching Job Opening News Forum Lab Only

Online Services

●I-TASSER ●I-TASSER-MTD ●C-I-TASSER ●CR-I-TASSER ●QUARK ●C-QUARK ●LOMETS ●MUSTER ●CEthreader ●SEGMER ●DeepFold ●DeepFoldRNA ●FoldDesign ●COFACTOR ●COACH ●MetaGO ●TripletGO ●IonCom ●FG-MD ●ModRefiner ●REMO ●DEMO ●DEMO-EM ●SPRING ●COTH ●Threpp ●PEPPI ●BSpred ●ANGLOR ●EDock ●BSP-SLIM ●SAXSTER ●FUpred ●ThreaDom ●ThreaDomEx ●EvoDesign ●BindProf ●BindProfX ●SSIPe ●GPCR-I-TASSER ●MAGELLAN ●ResQ ●STRUM ●DAMpred

●TM-score ●TM-align ●US-align ●MM-align ●RNA-align ●NW-align ●LS-align ●EDTSurf ●MVP ●MVP-Fit ●SPICKER ●HAAD ●PSSpred ●3DRobot ●MR-REX ●I-TASSER-MR ●SVMSEQ ●NeBcon ●ResPRE ●TripletRes ●DeepPotential ●WDL-RF ●ATPbind ●DockRMSD ●DeepMSA ●FASPR ●EM-Refiner ●GPU-I-TASSER

●BioLiP ●E. coli ●GLASS ●GPCR-HGmod ●GPCR-RD ●GPCR-EXP ●Tara-3D ●TM-fold ●DECOYS ●POTENTIAL ●RW/RWplus ●EvoEF ●HPSF ●THE-DB ●ADDRESS ●Alpaca-Antibody ●CASP7 ●CASP8 ●CASP9 ●CASP10 ●CASP11 ●CASP12 ●CASP13 ●CASP14

GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
Go back to previous page.

GPCR

Name	Prostaglandin E2 receptor EP3 subtype
Species	Mus musculus (Mouse)
Gene	Ptger3
Synonym	EP3 receptor PGE receptor EP3 subtype PGE2 receptor EP3 subtype prostaglandin E receptor 3 prostanoid EP3 receptor
Disease	N/A for non-human GPCRs
Length	365
Amino acid sequence	MASMWAPEHSAEAHSNLSSTTDDCGSVSVAFPITMMVTGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTSPVVILVYLSQRRWEQLDPSGRLCTFFGLTMTVFGLSSLLVASAMAVERALAIRAPHWYASHMKTRATPVLLGVWLSVLAFALLPVLGVGRYSVQWPGTWCFISTGPAGNETDPAREPGSVAFASAFACLGLLALVVTFACNLATIKALVSRCRAKAAVSQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLIMMLKMIFNQMSVEQCKTQMGKEKECNSFLIAVRLASLNQILDPWVYLLLRKILLRKFCQIRDHTNYASSSTSLPCPGSSALMWSDQLER
UniProt	P30557
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4336
IUPHAR	342
DrugBank	N/A

Ligand

Name	Prostaglandin E2
Molecular formula	C20H32O5
IUPAC name	(Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxocyclopentyl]hept-5-enoic acid
Molecular weight	352.471
Hydrogen bond acceptor	5
Hydrogen bond donor	3
XlogP	2.8
Synonyms	SR-05000001459 U-12,062 [3H]prostaglandin E2 Propess prosta-glandin e2 Prostaglandin E2, synthetic, powder, BioReagent, suitable for cell culture Prostin E EX-A1773 1798-EP2308872A1 HMS3268J12 l-PGE2 5-Heptenoic acid, 7-[3-hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl]- NCGC00092361-01 alpha, PGE2 NSC-165560 BR-72815 PGE2alpha Cervidil (TN) (15S)-Prostaglandin E2 (5Z,11\|A,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dienoic acid Dinoprostone Prostaglandin E2 (5Z,13E,15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dien-1-oic acid DSSTox_GSID_22947 1798-EP2277848A1 SR-05000001459-4 XEYBRNLFEZDVAW-ARSRFYASSA-N Prosta-5, 11,15-dihydroxy-9-oxo-, (5Z,11.alpha.,13E,15S)- Prostaglandin,PGE2 RP17686 GTPL1916 1798-EP2311829A1 HY-101952 363P246 LS-125823 9-oxo-11R,15S-dihydroxy-5Z,13E-prostadienoic acid NCGC00092361-04 B7005 NSC196514 C00584 (5Z,11?,13E,15S)-11,15-Dihydroxy-9-oxo-prosta-5,13-dien-1oic acid Dinoprostona (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate Dinoprostone, European Pharmacopoeia (EP) Reference Standard (Z)-7-((1R,2R,3R)-3-Hydroxy-2-((S,E)-3-hydroxyoct-1-en-1-yl)-5-oxocyclopentyl)hept-5-enoic acid E2 alpha, Prostaglandin 1798-EP2298767A1 SR-01000946417 U 12062 [3H]dinoprostone Prepidil Gel Prosta-5,13-dien-1-oic acid, 11,15-dihydroxy-9-oxo-, (5Z,11.alpha.,13E,15S)- Prostaglandin E2, >=93% (HPLC), synthetic Prostenone 1798-EP2305653A1 HMS1989K12 1798-EP2316829A1 K7Q1JQR04M 5-Heptenoic acid, 7-(3-hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl)-(8CI) Minprostin E2 AJ-45765 NSC 165560 BML1-F07 PGE2 CCG-208256 D00079 (5Z,11alpha,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dienoic acid Dinoprostone (JAN/USP/INN) (5Z,13E,15S)-11-alpha,15-dihydroxy-9-oxoprost-5,13-dienoate Dinoprostonum [INN-Latin] 05D31BD5-818B-4A92-8CFC-BEC19926A5B3 EINECS 206-656-6 SR-05000001459-1 U-12062 [3H]prostin E2 Propess (TN) Prostaglandin E Prostaglandin E2.alpha. Prostin E2 Gel, Prepidil 1798-EP2311453A1 HMS3402K12 l-Prostaglandin E2 7-(3-Hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl)-5-heptenoic acid NCGC00092361-02 alpha, Prostaglandin E2 NSC-196514 BRD-K26521938-001-04-9 Prepidil Cerviprime (5Z,11-alpha,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dien-1-oic acid DB00917 (5Z,13E)-(15S)-11alpha,15-Dihydroxy-9-oxoprost-13-enoate Dinoprostone [USAN:INN:BAN:JAN] (E,2R,3R)-7-[3-hydroxy-2-[(3S)-(3-hydroxy-1-octenyl)]-5-oxocyclopentyl]-5-heptenoic acid DSSTox_RID_76801 1798-EP2277858A1 Tox21_111196 ZINC3830713 Prosta-5, 11,5-dihydroxy-9-oxo-, (5Z,11.alpha.,13E,15S)- Prostaglandin E2 alpha Prostarmon E SCHEMBL25533 1798-EP2301922A1 HMS1361K12 1798-EP2314574A1 IDI1_033960 5-Heptenoic acid, 7-(3-hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl)- MFCD00077861 AC-6098 NCGC00092361-05 BC219642 P1884 CAS-363-24-6 CHEMBL548 (5Z,11alpha,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dien-1-oic Dinoprostona [INN-Spanish] (5Z,13E)-(15S)-11alpha,15-Dihydroxy-9-oxoprosta-5,13-dienoic acid Dinoprostone, United States Pharmacopeia (USP) Reference Standard (Z)-7-[(1r,2r,3r)-3-Hydroxy-2-[(E,3s)-3-Hydroxyoct-1-Enyl]-5-Oxo-Cyclopentyl]hept-5-Enoic Acid E2, Prostaglandin SR-01000946417-1 U,062 [3H]PGE2 Prestwick_793 Prosta-5,13-dien-1-oic acid, 11,15-dihydroxy-9-oxo-, (5Z,11alpha,13E,15S)- Prostaglandin E2, gamma-irradiated, powder, BioXtra, suitable for cell culture Prostin 1798-EP2308510A1 HMS2089D17 l-7-(3-Hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl)-5-heptenoic acid 5-Heptenoic acid, 7-(3-hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl)-, l- MolPort-003-939-184 AKOS015920228 NSC 196514 BMS-279654 & PGE2 PGE2 alpha Cervidil (-)-Prostaglandin E2 D06FEA (5Z,11I+/-,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dienoic acid Dinoprostone beta-Cyclodextrin Clathrate (5Z,13E,15S)-11-alpha,15-dihydroxy-9-oxoprost-5,13-dienoic acid DSSTox_CID_2947 1798-EP2272832A1 Enzaprost E SR-05000001459-3 UNII-K7Q1JQR04M Prosta-5, (5Z,11.alpha.,13E,15S)-11,15-dihydroxy-9-oxo- Prostaglandin E(2) Prostaglandin E2alpha Prostin E2 (TN) GTPL1883 1798-EP2311808A1 HMS3648F07 363-24-6 LMFA03010003 7-[3-Hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl]-5-heptenoic acid NCGC00092361-03 AN-10387 NSC165560 BSPBio_001490 CHEBI:15551 (5Z,11.alpha.,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dien-1-oic acid Dinoproston (5Z,13E)-(15S)-11alpha,15-Dihydroxy-9-oxoprost-13-enoic acid Dinoprostone [USAN:USP:INN:BAN:JAN] (E,Z)-(1R,2R,3R)-7-(3-Hydroxy-2-((3S)-(3-hydroxy-1-octenyl))-5-oxocyclopentyl)-5-heptenoic acid DTXSID4022947 1798-EP2295055A2 Tox21_111196_1 [3H]-PGE2 Prepidil (TN) Prosta-5,13-dien-1-oic acid, (5Z,11-alpha,13E,15S)-11,15-dihydroxy-9-oxo- Prostaglandin E2, 98% Prostarmon E2 SMP2_000056 1798-EP2305641A1 HMS1791K12 1798-EP2314587A1 J-502620 5-Heptenoic acid, 7-(3-hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl)- (8CI) Minprositin E2 AC1NQWXW NCGC00092361-06 BDBM35847 P2E CCG-208092 CS-6932 (5Z,11alpha,13E,15S)-11,15-dihydroxy-9-oxoprosta-5,13-dien-1-oic acid Dinoprostone (5Z,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dien-1-oic acid Dinoprostonum (Z)-7-[(1R,2R,3R)-3-Hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxocyclopentyl]hept-5-enoic acid E2alpha, Prostaglandin [ Show all ]
Inchi Key	XEYBRNLFEZDVAW-ARSRFYASSA-N
Inchi ID	InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1
PubChem CID	5280360
ChEMBL	CHEMBL548
IUPHAR	1916, 1883
BindingDB	35847
DrugBank	DB00917
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Kd	1.4 nM	PMID9313928	IUPHAR
Ki	0.85 nM	PMID9313928	IUPHAR
Ki	0.85 nM	PMID9313928	BindingDB
Ki	5.0 nM	PMID22119471, PMID22386979	BindingDB,ChEMBL

zhanglabzhanggroup.org | +65-6601-1241 | Computing 1, 13 Computing Drive, Singapore 117417