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Name | Platelet-activating factor receptor |
---|---|
Species | Cavia porcellus (Guinea pig) |
Gene | PTAFR |
Synonym | PAF-R PAFr |
Disease | N/A for non-human GPCRs |
Length | 342 |
Amino acid sequence | MELNSSSRVDSEFRYTLFPIVYSIIFVLGIIANGYVLWVFARLYPSKKLNEIKIFMVNLTVADLLFLITLPLWIVYYSNQGNWFLPKFLCNLAGCLFFINTYCSVAFLGVITYNRFQAVKYPIKTAQATTRKRGIALSLVIWVAIVAAASYFLVMDSTNVVSNKAGSGNITRCFEHYEKGSKPVLIIHICIVLGFFIVFLLILFCNLVIIHTLLRQPVKQQRNAEVRRRALWMVCTVLAVFVICFVPHHMVQLPWTLAELGMWPSSNHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKFRKHLSEKLNIMRSSQKCSRVTTDTGTEMAIPINHTPVNPIKN |
UniProt | P21556 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL5136 |
IUPHAR | N/A |
DrugBank | N/A |
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GLASS ID | Molecule | Formula | Molecular weight | H-bond acceptor / donor | XlogP | Lipinski's druglikeness |
---|---|---|---|---|---|---|
200 | CHEMBL151310 | C23H37NO4 | 391.552 | 4 / 0 | 4.2 | Yes |
916 | CHEMBL46754 | C37H56NO5PS | 657.891 | 6 / 0 | 12.6 | No |
1683 | CHEMBL52933 | C27H26F2N2O | 432.515 | 4 / 1 | 6.4 | No |
1685 | CHEMBL54935 | C27H26F2N2O | 432.515 | 4 / 1 | 6.4 | No |
519709 | CHEMBL351410 | C32H55N2O5+ | 547.801 | 5 / 0 | 8.8 | No |
519710 | CHEMBL126981 | C33H57N2O5+ | 561.828 | 5 / 0 | 8.7 | No |
519711 | CHEMBL157989 | C34H59N2O5+ | 575.855 | 5 / 0 | 9.9 | No |
519712 | CHEMBL290840 | C34H59N2O5+ | 575.855 | 5 / 0 | 9.9 | No |
519713 | CHEMBL160994 | C34H59N2O5+ | 575.855 | 5 / 0 | 9.9 | No |
3370 | CID 15005336 | C32H30ClN5O3 | 568.074 | 6 / 2 | 5.6 | No |
4126 | CHEMBL158974 | C33H57IN2O6 | 704.731 | 7 / 0 | N/A | No |
4252 | 2-[4-(2-Methyl-1H-imidazo[4,5-c]pyridin-1-yl)phenyl]-1,4-dihydro-5H-1-benzazepin-5-one | C23H18N4O | 366.424 | 4 / 1 | 3.9 | Yes |
519716 | CHEMBL12183 | C33H56N3O5S+ | 606.887 | 6 / 1 | 9.2 | No |
4343 | CHEMBL101957 | C28H30N4O | 438.575 | 4 / 1 | 3.5 | Yes |
4669 | CHEMBL46870 | C32H44NO6PS | 601.739 | 7 / 0 | 9.6 | No |
519718 | BDBM50004624 | C31H27ClN4O4 | 555.031 | 7 / 1 | 5.0 | No |
5079 | CHEMBL99053 | C30H25FN4O2S | 524.614 | 5 / 0 | 4.4 | No |
5416 | CHEMBL418989 | C28H31N5O3S | 517.648 | 7 / 0 | 2.9 | No |
5784 | CHEMBL53014 | C30H26N2O3 | 462.549 | 4 / 1 | 6.2 | No |
519724 | CHEMBL559013 | C21H21N5O | 359.433 | 4 / 1 | 1.7 | Yes |
6169 | CHEMBL134025 | C16H22N4O | 286.379 | 4 / 0 | 1.3 | Yes |
6932 | CHEMBL127766 | C36H61NO6S2 | 668.005 | 7 / 0 | N/A | No |
7576 | CHEMBL339676 | C36H59NO6S2 | 665.989 | 7 / 0 | N/A | No |
7908 | CHEMBL6263 | C36H53N3O10 | 687.831 | 10 / 0 | 5.7 | No |
7929 | 2-[4-(2-Methyl-1H-imidazo[4,5-c]pyridin-1-yl)phenyl]-4-(2-chloro-3-pyridinyl)-5-(2-pyridinylcarbamoyl)-6-methyl-1,4-dihydropyridine-3-carboxylic acid ethyl ester | C33H28ClN7O3 | 606.083 | 8 / 2 | 4.8 | No |
519731 | CHEMBL127875 | C30H56NO4S+ | 526.841 | 5 / 0 | 9.6 | No |
519732 | CHEMBL127009 | C32H60NO3S+ | 538.896 | 4 / 0 | 10.9 | No |
8370 | CHEMBL417563 | C19H17N3O3S | 367.423 | 6 / 1 | 2.6 | Yes |
8445 | CID 15005360 | C33H27ClN6O4 | 607.067 | 7 / 3 | 4.4 | No |
442060 | Ginkgolide C | C20H24O11 | 440.401 | 11 / 4 | -1.4 | No |
9089 | CHEMBL347488 | C20H24O11 | 440.401 | 11 / 4 | -1.4 | No |
442061 | CHEMBL3349895 | C20H24O11 | 440.401 | 11 / 4 | -1.4 | No |
9092 | CHEMBL156251 | C20H24O11 | 440.401 | 11 / 4 | -1.4 | No |
9373 | CHEMBL62322 | C26H32FNO2 | 409.545 | 4 / 1 | 5.1 | No |
519735 | CHEMBL127416 | C28H50NO3S+ | 480.772 | 4 / 0 | 9.6 | No |
10074 | CHEMBL12352 | C35H60ClN3O6 | 654.33 | 7 / 1 | N/A | No |
10833 | CHEMBL3216875 | C27H29Cl2N3O2 | 498.448 | 5 / 2 | N/A | N/A |
11094 | CHEMBL291177 | C30H42NO5PS | 559.702 | 6 / 0 | 9.9 | No |
11371 | CHEMBL1788193 | C34H60ClN3O6 | 642.319 | 7 / 1 | N/A | No |
11372 | CHEMBL2093039 | C34H60ClN3O6 | 642.319 | 7 / 1 | N/A | No |
11374 | CV-6209 | C34H60ClN3O6 | 642.319 | 7 / 1 | N/A | No |
12048 | LEXIPAFANT | C23H30N4O4S | 458.577 | 7 / 0 | 3.5 | Yes |
12244 | CID 15005338 | C33H29ClN4O3 | 565.07 | 6 / 2 | 6.0 | No |
12795 | CHEMBL174262 | C25H20N4O3 | 424.46 | 5 / 1 | 3.7 | Yes |
13750 | CHEMBL421843 | C32H55IN2O6 | 690.704 | 7 / 0 | N/A | No |
14009 | CHEMBL68407 | C25H30INO5 | 551.421 | 6 / 0 | N/A | No |
519749 | BDBM50004615 | C33H33ClN4O4 | 585.101 | 7 / 0 | 5.8 | No |
14653 | CHEMBL125576 | C33H56ClN3O6 | 626.276 | 8 / 1 | N/A | No |
14865 | CHEMBL318908 | C27H27N5O2 | 453.546 | 6 / 0 | 4.0 | Yes |
519754 | CHEMBL340480 | C31H55N2O4+ | 519.791 | 4 / 1 | 8.7 | No |
15058 | CHEMBL47192 | C28H38NO5PS | 531.648 | 6 / 0 | 8.8 | No |
15251 | CHEMBL421954 | C27H36O5 | 440.58 | 5 / 0 | 6.1 | No |
15778 | CHEMBL118182 | C21H16N6O | 368.4 | 5 / 1 | 2.2 | Yes |
16526 | CHEMBL64209 | C20H21N3O3S2 | 415.526 | 6 / 1 | 2.8 | Yes |
519765 | CHEMBL349327 | C33H51N2O4+ | 539.781 | 4 / 0 | 9.2 | No |
17822 | CHEMBL300742 | C27H26F2N2O | 432.515 | 4 / 1 | 6.4 | No |
18141 | CHEMBL103571 | C28H29N5O2 | 467.573 | 5 / 0 | 3.1 | Yes |
519775 | CHEMBL554536 | C17H14ClN3OS | 343.829 | 4 / 1 | 3.1 | Yes |
519783 | BDBM50004634 | C35H29N7O3 | 595.663 | 8 / 1 | 4.1 | No |
20161 | CHEMBL443811 | C27H44N4O | 440.676 | 4 / 0 | 7.3 | No |
519787 | CHEMBL338883 | C28H50NO4S+ | 496.771 | 5 / 0 | 9.4 | No |
21070 | CHEMBL48129 | C32H46NO5PS | 587.756 | 6 / 0 | 11.0 | No |
21993 | CHEMBL367418 | C30H30FN5O2 | 511.601 | 5 / 0 | 4.8 | No |
22020 | CHEMBL132028 | C26H34N2O8 | 502.564 | 8 / 0 | 2.4 | No |
22224 | CHEMBL66814 | C24H34INO5 | 543.442 | 6 / 0 | N/A | No |
519799 | BDBM50014011 | C16H25NO4S | 327.439 | 6 / 0 | 2.5 | Yes |
22945 | CHEMBL47159 | C33H46NO6PS | 615.766 | 7 / 0 | 10.0 | No |
519805 | CHEMBL545773 | C27H29N5O | 439.563 | 5 / 1 | 3.0 | Yes |
519811 | CHEMBL124312 | C30H62NO3+ | 484.83 | 3 / 0 | 10.1 | No |
519812 | CHEMBL64493 | C24H21N3O2S | 415.511 | 5 / 1 | 4.0 | Yes |
519815 | CHEMBL154459 | C34H53N2O3+ | 537.809 | 3 / 0 | 10.0 | No |
25648 | CHEMBL118672 | C27H27N7O2 | 481.56 | 6 / 0 | 2.6 | Yes |
25840 | CHEMBL3215984 | C18H20Cl2N4O | 379.285 | 4 / 2 | N/A | N/A |
519816 | BDBM50006101 | C30H54N2O6PS- | 601.804 | 7 / 1 | 8.0 | No |
26212 | CHEMBL1160088 | C30H55N2O6PS | 602.812 | 7 / 2 | 8.0 | No |
26458 | CHEMBL268597 | C32H42N2O10 | 614.692 | 10 / 0 | 4.2 | No |
26732 | CHEMBL103903 | C27H26N4O | 422.532 | 4 / 0 | 4.3 | Yes |
27159 | CHEMBL545072 | C27H30ClN5O | 476.021 | 5 / 1 | N/A | N/A |
27880 | CHEMBL338689 | C32H55IN2O5 | 674.705 | 6 / 0 | N/A | No |
27946 | CHEMBL273638 | C42H65ClN4O6 | 757.454 | 7 / 1 | N/A | No |
558119 | CHEMBL325928 | C21H19N7O | 385.431 | 5 / 1 | 2.0 | Yes |
28979 | CHEMBL20522 | C29H62BrNO4 | 568.722 | 5 / 1 | N/A | No |
519829 | CHEMBL64860 | C25H21N3O3S | 443.521 | 6 / 1 | 4.1 | Yes |
519833 | CHEMBL421618 | C31H53N2O4+ | 517.775 | 4 / 0 | 9.0 | No |
29714 | CHEMBL118793 | C24H25N7O | 427.512 | 5 / 0 | 2.9 | Yes |
30851 | CHEMBL65715 | C28H37FN2O4 | 484.612 | 6 / 4 | 3.8 | Yes |
31307 | CHEMBL64860 | C27H23N3O7S | 533.555 | 10 / 3 | N/A | No |
31499 | CHEMBL295148 | C34H50NO5PS | 615.81 | 6 / 0 | 11.4 | No |
31575 | CHEMBL24879 | C34H49N3O10 | 659.777 | 10 / 1 | 5.3 | No |
519846 | CHEMBL66185 | C26H46NO5+ | 452.656 | 5 / 0 | 7.0 | No |
31795 | CHEMBL103561 | C28H31N5O | 453.59 | 5 / 1 | 3.3 | Yes |
519850 | CHEMBL12554 | C35H60N3O6+ | 618.88 | 6 / 1 | 9.5 | No |
519851 | CHEMBL12882 | C35H60N3O6+ | 618.88 | 6 / 1 | 9.5 | No |
519852 | CHEMBL340164 | C31H58NO3S+ | 524.869 | 4 / 0 | 10.2 | No |
32522 | CHEMBL64636 | C23H18FN3O2S | 419.474 | 6 / 2 | 4.0 | Yes |
33119 | CHEMBL2114378 | C22H24O6 | 384.428 | 6 / 0 | 3.2 | Yes |
33120 | CHEMBL2115333 | C22H24O6 | 384.428 | 6 / 0 | 3.2 | Yes |
33162 | CHEMBL127531 | C24H50NO5P | 463.64 | 5 / 0 | 6.7 | No |
33585 | CHEMBL293653 | C19H19N3O3S | 369.439 | 6 / 2 | 2.3 | Yes |
33661 | CHEMBL102070 | C27H28N6O2 | 468.561 | 6 / 1 | 1.7 | Yes |
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