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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Platelet-activating factor receptor
Species	Cavia porcellus (Guinea pig)
Gene	PTAFR
Synonym	PAF-R PAFr
Disease	N/A for non-human GPCRs
Length	342
Amino acid sequence	MELNSSSRVDSEFRYTLFPIVYSIIFVLGIIANGYVLWVFARLYPSKKLNEIKIFMVNLTVADLLFLITLPLWIVYYSNQGNWFLPKFLCNLAGCLFFINTYCSVAFLGVITYNRFQAVKYPIKTAQATTRKRGIALSLVIWVAIVAAASYFLVMDSTNVVSNKAGSGNITRCFEHYEKGSKPVLIIHICIVLGFFIVFLLILFCNLVIIHTLLRQPVKQQRNAEVRRRALWMVCTVLAVFVICFVPHHMVQLPWTLAELGMWPSSNHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKFRKHLSEKLNIMRSSQKCSRVTTDTGTEMAIPINHTPVNPIKN
UniProt	P21556
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5136
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL118672
Molecular formula	C27H27N7O2
IUPAC name	N,N-diethyl-5-methyl-2-[4-(2-methylimidazo[4,5-c]pyridin-1-yl)phenyl]-4-oxo-3H-pyrido[2,3-b][1,4]diazepine-8-carboxamide
Molecular weight	481.56
Hydrogen bond acceptor	6
Hydrogen bond donor	0
XlogP	2.6
Synonyms	BDBM50033230 N,N-Diethyl-2-[4-(2-methyl-1H-imidazo[4,5-c]pyridin-1-yl)phenyl]-4-oxo-5-methyl-4,5-dihydro-3H-pyrido[2,3-b][1,4]diazepine-8-carboxamide 5-Methyl-2-[4-(2-methyl-imidazo[4,5-c]pyridin-1-yl)-phenyl]-4-oxo-4,5-dihydro-3H-pyrido[3,4-b][1,4]diazepine-8-carboxylic acid diethylamide
Inchi Key	BKCBZQAFYITIIP-UHFFFAOYSA-N
Inchi ID	InChI=1S/C27H27N7O2/c1-5-33(6-2)27(36)19-13-22-26(29-15-19)32(4)25(35)14-21(31-22)18-7-9-20(10-8-18)34-17(3)30-23-16-28-12-11-24(23)34/h7-13,15-16H,5-6,14H2,1-4H3
PubChem CID	10480355
ChEMBL	CHEMBL118672
IUPHAR	N/A
BindingDB	50033230
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	3.2 nM	PMID7658439	BindingDB,ChEMBL

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