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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Platelet-activating factor receptor
Species	Cavia porcellus (Guinea pig)
Gene	PTAFR
Synonym	PAF-R PAFr
Disease	N/A for non-human GPCRs
Length	342
Amino acid sequence	MELNSSSRVDSEFRYTLFPIVYSIIFVLGIIANGYVLWVFARLYPSKKLNEIKIFMVNLTVADLLFLITLPLWIVYYSNQGNWFLPKFLCNLAGCLFFINTYCSVAFLGVITYNRFQAVKYPIKTAQATTRKRGIALSLVIWVAIVAAASYFLVMDSTNVVSNKAGSGNITRCFEHYEKGSKPVLIIHICIVLGFFIVFLLILFCNLVIIHTLLRQPVKQQRNAEVRRRALWMVCTVLAVFVICFVPHHMVQLPWTLAELGMWPSSNHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKFRKHLSEKLNIMRSSQKCSRVTTDTGTEMAIPINHTPVNPIKN
UniProt	P21556
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5136
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL46754
Molecular formula	C37H56NO5PS
IUPAC name	(2,5-ditert-butyl-4-dodecoxyphenyl) [3-[(5-methyl-1,3-thiazol-3-ium-3-yl)methyl]phenyl] phosphate
Molecular weight	657.891
Hydrogen bond acceptor	6
Hydrogen bond donor	0
XlogP	12.6
Synonyms	BDBM50006082 3-{3-[(2,5-Di-tert-butyl-4-dodecyloxy-phenoxy)-hydroxy-phosphoryloxy]-benzyl}-5-methyl-thiazol-3-ium
Inchi Key	ABJVOKFFSVZWAP-UHFFFAOYSA-N
Inchi ID	InChI=1S/C37H56NO5PS/c1-9-10-11-12-13-14-15-16-17-18-22-41-34-24-33(37(6,7)8)35(25-32(34)36(3,4)5)43-44(39,40)42-31-21-19-20-30(23-31)27-38-26-29(2)45-28-38/h19-21,23-26,28H,9-18,22,27H2,1-8H3
PubChem CID	14992453
ChEMBL	CHEMBL46754
IUPHAR	N/A
BindingDB	50006082
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	90.0 nM	PMID1578493	BindingDB,ChEMBL

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