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GPCR

NamePlatelet-activating factor receptor
SpeciesCavia porcellus (Guinea pig)
GenePTAFR
SynonymPAF-R
PAFr
DiseaseN/A for non-human GPCRs
Length342
Amino acid sequenceMELNSSSRVDSEFRYTLFPIVYSIIFVLGIIANGYVLWVFARLYPSKKLNEIKIFMVNLTVADLLFLITLPLWIVYYSNQGNWFLPKFLCNLAGCLFFINTYCSVAFLGVITYNRFQAVKYPIKTAQATTRKRGIALSLVIWVAIVAAASYFLVMDSTNVVSNKAGSGNITRCFEHYEKGSKPVLIIHICIVLGFFIVFLLILFCNLVIIHTLLRQPVKQQRNAEVRRRALWMVCTVLAVFVICFVPHHMVQLPWTLAELGMWPSSNHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKFRKHLSEKLNIMRSSQKCSRVTTDTGTEMAIPINHTPVNPIKN
UniProtP21556
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5136
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL545773
Molecular formulaC27H29N5O
IUPAC name2-[4-[2-(1,2-diphenylethylamino)acetyl]piperazin-1-yl]-2-pyridin-3-ylacetonitrile
Molecular weight439.563
Hydrogen bond acceptor5
Hydrogen bond donor1
XlogP3.0
SynonymsCHEMBL1194240
{4-[2-(1,2-Diphenyl-ethylamino)-acetyl]-piperazin-1-yl}-pyridin-3-yl-acetonitrile; trihydrochloride; hydrate
BDBM50003474
SCHEMBL9852864
Inchi KeyBGSCELVHAPWUET-UHFFFAOYSA-N
Inchi IDInChI=1S/C27H29N5O/c28-19-26(24-12-7-13-29-20-24)31-14-16-32(17-15-31)27(33)21-30-25(23-10-5-2-6-11-23)18-22-8-3-1-4-9-22/h1-13,20,25-26,30H,14-18,21H2
PubChem CID10365929
ChEMBLN/A
IUPHARN/A
BindingDB50003474
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC5050.0 nMPMID1433215BindingDB

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