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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Platelet-activating factor receptor
Species	Cavia porcellus (Guinea pig)
Gene	PTAFR
Synonym	PAF-R PAFr
Disease	N/A for non-human GPCRs
Length	342
Amino acid sequence	MELNSSSRVDSEFRYTLFPIVYSIIFVLGIIANGYVLWVFARLYPSKKLNEIKIFMVNLTVADLLFLITLPLWIVYYSNQGNWFLPKFLCNLAGCLFFINTYCSVAFLGVITYNRFQAVKYPIKTAQATTRKRGIALSLVIWVAIVAAASYFLVMDSTNVVSNKAGSGNITRCFEHYEKGSKPVLIIHICIVLGFFIVFLLILFCNLVIIHTLLRQPVKQQRNAEVRRRALWMVCTVLAVFVICFVPHHMVQLPWTLAELGMWPSSNHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKFRKHLSEKLNIMRSSQKCSRVTTDTGTEMAIPINHTPVNPIKN
UniProt	P21556
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5136
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL118182
Molecular formula	C21H16N6O
IUPAC name	4-[4-(2-methylimidazo[4,5-c]pyridin-1-yl)phenyl]-1,3-dihydropyrido[2,3-b][1,4]diazepin-2-one
Molecular weight	368.4
Hydrogen bond acceptor	5
Hydrogen bond donor	1
XlogP	2.2
Synonyms	4-[4-(2-Methyl-imidazo[4,5-c]pyridin-1-yl)-phenyl]-1,3-dihydro-pyrido[3,4-b][1,4]diazepin-2-one BDBM50033265
Inchi Key	AVZCLRAKXPWOSU-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H16N6O/c1-13-24-18-12-22-10-8-19(18)27(13)15-6-4-14(5-7-15)17-11-20(28)25-16-3-2-9-23-21(16)26-17/h2-10,12H,11H2,1H3,(H,25,28)
PubChem CID	10384391
ChEMBL	CHEMBL118182
IUPHAR	N/A
BindingDB	50033265
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	66.0 nM	PMID7658439	BindingDB,ChEMBL

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