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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Platelet-activating factor receptor
Species	Cavia porcellus (Guinea pig)
Gene	PTAFR
Synonym	PAF-R PAFr
Disease	N/A for non-human GPCRs
Length	342
Amino acid sequence	MELNSSSRVDSEFRYTLFPIVYSIIFVLGIIANGYVLWVFARLYPSKKLNEIKIFMVNLTVADLLFLITLPLWIVYYSNQGNWFLPKFLCNLAGCLFFINTYCSVAFLGVITYNRFQAVKYPIKTAQATTRKRGIALSLVIWVAIVAAASYFLVMDSTNVVSNKAGSGNITRCFEHYEKGSKPVLIIHICIVLGFFIVFLLILFCNLVIIHTLLRQPVKQQRNAEVRRRALWMVCTVLAVFVICFVPHHMVQLPWTLAELGMWPSSNHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKFRKHLSEKLNIMRSSQKCSRVTTDTGTEMAIPINHTPVNPIKN
UniProt	P21556
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5136
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	BDBM50004624
Molecular formula	C31H27ClN4O4
IUPAC name	ethyl 4-(2-chlorophenyl)-2-methyl-6-[4-(4-methyl-1,3-oxazol-5-yl)phenyl]-3-(pyridin-2-ylcarbamoyl)-3,4-dihydropyridine-5-carboxylate
Molecular weight	555.031
Hydrogen bond acceptor	7
Hydrogen bond donor	1
XlogP	5.0
Synonyms	4-(2-Chloro-phenyl)-6-methyl-2-[4-(4-methyl-oxazol-5-yl)-phenyl]-5-(pyridin-2-ylcarbamoyl)-1,4-dihydro-pyridine-3-carboxylic acid ethyl ester (0.2Et2O)
Inchi Key	AGNYLCYZRJEYLT-UHFFFAOYSA-N
Inchi ID	InChI=1S/C31H27ClN4O4/c1-4-39-31(38)27-26(22-9-5-6-10-23(22)32)25(30(37)36-24-11-7-8-16-33-24)18(2)35-28(27)20-12-14-21(15-13-20)29-19(3)34-17-40-29/h5-17,25-26H,4H2,1-3H3,(H,33,36,37)
PubChem CID	53641826
ChEMBL	N/A
IUPHAR	N/A
BindingDB	50004624
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
IC50	200.0 nM	PMID1507200	BindingDB

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