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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Platelet-activating factor receptor
Species	Cavia porcellus (Guinea pig)
Gene	PTAFR
Synonym	PAF-R PAFr
Disease	N/A for non-human GPCRs
Length	342
Amino acid sequence	MELNSSSRVDSEFRYTLFPIVYSIIFVLGIIANGYVLWVFARLYPSKKLNEIKIFMVNLTVADLLFLITLPLWIVYYSNQGNWFLPKFLCNLAGCLFFINTYCSVAFLGVITYNRFQAVKYPIKTAQATTRKRGIALSLVIWVAIVAAASYFLVMDSTNVVSNKAGSGNITRCFEHYEKGSKPVLIIHICIVLGFFIVFLLILFCNLVIIHTLLRQPVKQQRNAEVRRRALWMVCTVLAVFVICFVPHHMVQLPWTLAELGMWPSSNHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKFRKHLSEKLNIMRSSQKCSRVTTDTGTEMAIPINHTPVNPIKN
UniProt	P21556
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5136
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL62322
Molecular formula	C26H32FNO2
IUPAC name	8-[5-(4-fluorophenyl)pentan-2-yl]-10-methoxy-5,5-dimethyl-1,2,3,4-tetrahydrochromeno[4,3-c]pyridine
Molecular weight	409.545
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	5.1
Synonyms	7-[4-(4-Fluoro-phenyl)-1-methyl-butyl]-5-methoxy-10,10-dimethyl-2,3,4,10-tetrahydro-1H-9-oxa-3-aza-phenanthrene 1,3,4,5-Tetrahydro-8-[4-(4-fluorophenyl)-1-methylbutyl]-10-methoxy-5,5-dimethyl-2H-[1]benzopyrano[4,3-c]pyridine BDBM50000703
Inchi Key	AMZHBXGJIJPSJR-UHFFFAOYSA-N
Inchi ID	InChI=1S/C26H32FNO2/c1-17(6-5-7-18-8-10-20(27)11-9-18)19-14-23(29-4)25-21-16-28-13-12-22(21)26(2,3)30-24(25)15-19/h8-11,14-15,17,28H,5-7,12-13,16H2,1-4H3
PubChem CID	14983486
ChEMBL	CHEMBL62322
IUPHAR	N/A
BindingDB	50000703
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Ki	16900.0 nM	PMID1317924	BindingDB,ChEMBL

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