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GPCR

NamePlatelet-activating factor receptor
SpeciesCavia porcellus (Guinea pig)
GenePTAFR
SynonymPAF-R
PAFr
DiseaseN/A for non-human GPCRs
Length342
Amino acid sequenceMELNSSSRVDSEFRYTLFPIVYSIIFVLGIIANGYVLWVFARLYPSKKLNEIKIFMVNLTVADLLFLITLPLWIVYYSNQGNWFLPKFLCNLAGCLFFINTYCSVAFLGVITYNRFQAVKYPIKTAQATTRKRGIALSLVIWVAIVAAASYFLVMDSTNVVSNKAGSGNITRCFEHYEKGSKPVLIIHICIVLGFFIVFLLILFCNLVIIHTLLRQPVKQQRNAEVRRRALWMVCTVLAVFVICFVPHHMVQLPWTLAELGMWPSSNHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKFRKHLSEKLNIMRSSQKCSRVTTDTGTEMAIPINHTPVNPIKN
UniProtP21556
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5136
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL127009
Molecular formulaC32H60NO3S+
IUPAC name3-[5-[[5-(octadecoxymethyl)oxolan-3-yl]methoxy]pentyl]-1,3-thiazol-3-ium
Molecular weight538.896
Hydrogen bond acceptor4
Hydrogen bond donor0
XlogP10.9
SynonymsBDBM50011123
Toluene-4-sulfonate3-[5-(5-octadecyloxymethyl-tetrahydro-furan-3-ylmethoxy)-pentyl]-thiazol-3-ium;Toluene-4-sulfonate
3-[5-[[Tetrahydro-5-octadecyloxymethylfuran]-3-ylmethoxy]pentyl]thiazolium
CHEMBL1180462
Inchi KeyALGZZFMKKJAXDR-UHFFFAOYSA-N
Inchi IDInChI=1S/C32H60NO3S/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-19-24-35-29-32-26-31(28-36-32)27-34-23-20-17-18-21-33-22-25-37-30-33/h22,25,30-32H,2-21,23-24,26-29H2,1H3/q+1
PubChem CID14785866
ChEMBLN/A
IUPHARN/A
BindingDB50011123
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.
This ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
IC502100.0 nMPMID1992139BindingDB

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