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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Platelet-activating factor receptor
Species	Cavia porcellus (Guinea pig)
Gene	PTAFR
Synonym	PAF-R PAFr
Disease	N/A for non-human GPCRs
Length	342
Amino acid sequence	MELNSSSRVDSEFRYTLFPIVYSIIFVLGIIANGYVLWVFARLYPSKKLNEIKIFMVNLTVADLLFLITLPLWIVYYSNQGNWFLPKFLCNLAGCLFFINTYCSVAFLGVITYNRFQAVKYPIKTAQATTRKRGIALSLVIWVAIVAAASYFLVMDSTNVVSNKAGSGNITRCFEHYEKGSKPVLIIHICIVLGFFIVFLLILFCNLVIIHTLLRQPVKQQRNAEVRRRALWMVCTVLAVFVICFVPHHMVQLPWTLAELGMWPSSNHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKFRKHLSEKLNIMRSSQKCSRVTTDTGTEMAIPINHTPVNPIKN
UniProt	P21556
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5136
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL53014
Molecular formula	C30H26N2O3
IUPAC name	(2E)-5,5-bis(4-methoxyphenyl)-N-(4-pyridin-3-ylphenyl)penta-2,4-dienamide
Molecular weight	462.549
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	6.2
Synonyms	SCHEMBL9519813 BDBM50018347 SCHEMBL9519798 5,5-Bis-(4-methoxy-phenyl)-penta-2,4-dienoic acid (4-pyridin-3-yl-phenyl)-amide
Inchi Key	AHPDSBLXHZAIHR-XVNBXDOJSA-N
Inchi ID	InChI=1S/C30H26N2O3/c1-34-27-16-10-23(11-17-27)29(24-12-18-28(35-2)19-13-24)6-3-7-30(33)32-26-14-8-22(9-15-26)25-5-4-20-31-21-25/h3-21H,1-2H3,(H,32,33)/b7-3+
PubChem CID	14347434
ChEMBL	CHEMBL53014
IUPHAR	N/A
BindingDB	50018347
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
ID50	0.15 mg.kg-1	PMID2754709	ChEMBL
Inhibition	82.0 %	PMID2754709	ChEMBL

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