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GPCR

NamePlatelet-activating factor receptor
SpeciesCavia porcellus (Guinea pig)
GenePTAFR
SynonymPAF-R
PAFr
DiseaseN/A for non-human GPCRs
Length342
Amino acid sequenceMELNSSSRVDSEFRYTLFPIVYSIIFVLGIIANGYVLWVFARLYPSKKLNEIKIFMVNLTVADLLFLITLPLWIVYYSNQGNWFLPKFLCNLAGCLFFINTYCSVAFLGVITYNRFQAVKYPIKTAQATTRKRGIALSLVIWVAIVAAASYFLVMDSTNVVSNKAGSGNITRCFEHYEKGSKPVLIIHICIVLGFFIVFLLILFCNLVIIHTLLRQPVKQQRNAEVRRRALWMVCTVLAVFVICFVPHHMVQLPWTLAELGMWPSSNHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKFRKHLSEKLNIMRSSQKCSRVTTDTGTEMAIPINHTPVNPIKN
UniProtP21556
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5136
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL338883
Molecular formulaC28H50NO4S+
IUPAC name(2-pentadecyl-1,3-dioxolan-4-yl)methyl 6-(1,3-thiazol-3-ium-3-yl)hexanoate
Molecular weight496.771
Hydrogen bond acceptor5
Hydrogen bond donor0
XlogP9.4
SynonymsBDBM50011105
Toluene-4-sulfonate3-[5-(2-pentadecyl-[1,3]dioxolan-4-ylmethoxycarbonyl)-pentyl]-thiazol-3-ium;Toluene-4-sulfonate
3-[6-(2-Pentadecyl-1,3-dioxolan-4-ylmethoxy)-6-oxohexyl]thiazolium
CHEMBL1184206
Inchi KeyBCWRLEXSMMOTFY-UHFFFAOYSA-N
Inchi IDInChI=1S/C28H50NO4S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-19-28-32-24-26(33-28)23-31-27(30)18-15-14-17-20-29-21-22-34-25-29/h21-22,25-26,28H,2-20,23-24H2,1H3/q+1
PubChem CID14785920
ChEMBLN/A
IUPHARN/A
BindingDB50011105
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
IC503000.0 nMPMID1992139BindingDB

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