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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Platelet-activating factor receptor
Species	Cavia porcellus (Guinea pig)
Gene	PTAFR
Synonym	PAF-R PAFr
Disease	N/A for non-human GPCRs
Length	342
Amino acid sequence	MELNSSSRVDSEFRYTLFPIVYSIIFVLGIIANGYVLWVFARLYPSKKLNEIKIFMVNLTVADLLFLITLPLWIVYYSNQGNWFLPKFLCNLAGCLFFINTYCSVAFLGVITYNRFQAVKYPIKTAQATTRKRGIALSLVIWVAIVAAASYFLVMDSTNVVSNKAGSGNITRCFEHYEKGSKPVLIIHICIVLGFFIVFLLILFCNLVIIHTLLRQPVKQQRNAEVRRRALWMVCTVLAVFVICFVPHHMVQLPWTLAELGMWPSSNHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKFRKHLSEKLNIMRSSQKCSRVTTDTGTEMAIPINHTPVNPIKN
UniProt	P21556
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5136
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	BDBM50014011
Molecular formula	C16H25NO4S
IUPAC name	3-O-ethyl 5-O-(2-methylsulfanylethyl) 4-ethyl-2,6-dimethyl-3,4-dihydropyridine-3,5-dicarboxylate
Molecular weight	327.439
Hydrogen bond acceptor	6
Hydrogen bond donor	0
XlogP	2.5
Synonyms	4-Ethyl-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-(2-methylsulfanyl-ethyl) ester
Inchi Key	BFZXFBSVTFGAMA-UHFFFAOYSA-N
Inchi ID	InChI=1S/C16H25NO4S/c1-6-12-13(15(18)20-7-2)10(3)17-11(4)14(12)16(19)21-8-9-22-5/h12-13H,6-9H2,1-5H3
PubChem CID	53680099
ChEMBL	N/A
IUPHAR	N/A
BindingDB	50014011
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	1012.0 nM	PMID2175357	BindingDB

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