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Name | Platelet-activating factor receptor |
---|---|
Species | Cavia porcellus (Guinea pig) |
Gene | PTAFR |
Synonym | PAF-R PAFr |
Disease | N/A for non-human GPCRs |
Length | 342 |
Amino acid sequence | MELNSSSRVDSEFRYTLFPIVYSIIFVLGIIANGYVLWVFARLYPSKKLNEIKIFMVNLTVADLLFLITLPLWIVYYSNQGNWFLPKFLCNLAGCLFFINTYCSVAFLGVITYNRFQAVKYPIKTAQATTRKRGIALSLVIWVAIVAAASYFLVMDSTNVVSNKAGSGNITRCFEHYEKGSKPVLIIHICIVLGFFIVFLLILFCNLVIIHTLLRQPVKQQRNAEVRRRALWMVCTVLAVFVICFVPHHMVQLPWTLAELGMWPSSNHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKFRKHLSEKLNIMRSSQKCSRVTTDTGTEMAIPINHTPVNPIKN |
UniProt | P21556 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL5136 |
IUPHAR | N/A |
DrugBank | N/A |
Name | CHEMBL273638 |
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Molecular formula | C42H65ClN4O6 |
IUPAC name | [(2R,4R)-1-benzoyl-4-(octadecylcarbamoyloxymethyl)azetidin-2-yl]methyl N-acetyl-N-[(1-ethylpyridin-1-ium-2-yl)methyl]carbamate;chloride |
Molecular weight | 757.454 |
Hydrogen bond acceptor | 7 |
Hydrogen bond donor | 1 |
XlogP | None |
Synonyms | N/A |
Inchi Key | BNBMJJSMZNFFEX-RUKDTIIFSA-N |
Inchi ID | InChI=1S/C42H64N4O6.ClH/c1-4-6-7-8-9-10-11-12-13-14-15-16-17-18-19-24-29-43-41(49)51-33-38-31-39(46(38)40(48)36-26-21-20-22-27-36)34-52-42(50)45(35(3)47)32-37-28-23-25-30-44(37)5-2;/h20-23,25-28,30,38-39H,4-19,24,29,31-34H2,1-3H3;1H/t38-,39-;/m1./s1 |
PubChem CID | 44268191 |
ChEMBL | CHEMBL273638 |
IUPHAR | N/A |
BindingDB | N/A |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. Partition coefficient log P of this ligand is not available. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 138.0 nM | Bioorg. Med. Chem. Lett., (1995) 5:10:1097 | ChEMBL |
Ki | 104.0 nM | Bioorg. Med. Chem. Lett., (1995) 5:10:1097 | ChEMBL |
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