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Name | Platelet-activating factor receptor |
---|---|
Species | Cavia porcellus (Guinea pig) |
Gene | PTAFR |
Synonym | PAF-R PAFr |
Disease | N/A for non-human GPCRs |
Length | 342 |
Amino acid sequence | MELNSSSRVDSEFRYTLFPIVYSIIFVLGIIANGYVLWVFARLYPSKKLNEIKIFMVNLTVADLLFLITLPLWIVYYSNQGNWFLPKFLCNLAGCLFFINTYCSVAFLGVITYNRFQAVKYPIKTAQATTRKRGIALSLVIWVAIVAAASYFLVMDSTNVVSNKAGSGNITRCFEHYEKGSKPVLIIHICIVLGFFIVFLLILFCNLVIIHTLLRQPVKQQRNAEVRRRALWMVCTVLAVFVICFVPHHMVQLPWTLAELGMWPSSNHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKFRKHLSEKLNIMRSSQKCSRVTTDTGTEMAIPINHTPVNPIKN |
UniProt | P21556 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL5136 |
IUPHAR | N/A |
DrugBank | N/A |
Name | CHEMBL290840 |
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Molecular formula | C34H59N2O5+ |
IUPAC name | (5-octadecoxyoxolan-3-yl)methyl N-acetyl-N-[(1-ethylpyridin-1-ium-2-yl)methyl]carbamate |
Molecular weight | 575.855 |
Hydrogen bond acceptor | 5 |
Hydrogen bond donor | 0 |
XlogP | 9.9 |
Synonyms | BDBM50005229 2-[N-Acetyl-N-[[[tetrahydro-5-octadecyloxyfuran]-3-yl]methoxycarbonyl]aminomethyl]-1-ethylpyridinium CHEMBL1181271 2-{[Acetyl-(5-octadecyloxy-tetrahydro-furan-3-ylmethoxycarbonyl)-amino]-methyl}-1-ethyl-pyridinium; chloride AC1L30F2 [ Show all ] |
Inchi Key | AEBQYQRMRZSJQU-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C34H59N2O5/c1-4-6-7-8-9-10-11-12-13-14-15-16-17-18-19-22-25-39-33-26-31(28-40-33)29-41-34(38)36(30(3)37)27-32-23-20-21-24-35(32)5-2/h20-21,23-24,31,33H,4-19,22,25-29H2,1-3H3/q+1 |
PubChem CID | 132115 |
ChEMBL | N/A |
IUPHAR | N/A |
BindingDB | 50005229 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 13.0 nM | PMID1542094 | BindingDB |
IC50 | 21.0 nM | PMID1542094 | BindingDB |
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