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Name | Platelet-activating factor receptor |
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Species | Cavia porcellus (Guinea pig) |
Gene | PTAFR |
Synonym | PAF-R PAFr |
Disease | N/A for non-human GPCRs |
Length | 342 |
Amino acid sequence | MELNSSSRVDSEFRYTLFPIVYSIIFVLGIIANGYVLWVFARLYPSKKLNEIKIFMVNLTVADLLFLITLPLWIVYYSNQGNWFLPKFLCNLAGCLFFINTYCSVAFLGVITYNRFQAVKYPIKTAQATTRKRGIALSLVIWVAIVAAASYFLVMDSTNVVSNKAGSGNITRCFEHYEKGSKPVLIIHICIVLGFFIVFLLILFCNLVIIHTLLRQPVKQQRNAEVRRRALWMVCTVLAVFVICFVPHHMVQLPWTLAELGMWPSSNHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKFRKHLSEKLNIMRSSQKCSRVTTDTGTEMAIPINHTPVNPIKN |
UniProt | P21556 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL5136 |
IUPHAR | N/A |
DrugBank | N/A |
Name | CHEMBL421954 |
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Molecular formula | C27H36O5 |
IUPAC name | phenyl [(1R,3S,5R,8E,12S,13R,16S)-5,9,12,13-tetramethyl-2-oxo-4-oxatricyclo[10.3.1.03,5]hexadec-8-en-16-yl]methyl carbonate |
Molecular weight | 440.58 |
Hydrogen bond acceptor | 5 |
Hydrogen bond donor | 0 |
XlogP | 6.1 |
Synonyms | BDBM50055484 Carbonic acid phenyl ester (E)-(1R,3S,5R,12S,13R,16S)-5,9,12,13-tetramethyl-2-oxo-4-oxa-tricyclo[10.3.1.0*3,5*]hexadec-8-en-16-ylmethyl ester |
Inchi Key | AVFNXDMKAUKSEC-JGOJIRBSSA-N |
Inchi ID | InChI=1S/C27H36O5/c1-18-9-8-15-27(4)24(32-27)23(28)21-13-12-19(2)26(3,16-14-18)22(21)17-30-25(29)31-20-10-6-5-7-11-20/h5-7,9-11,19,21-22,24H,8,12-17H2,1-4H3/b18-9+/t19-,21-,22+,24-,26+,27-/m1/s1 |
PubChem CID | 10765571 |
ChEMBL | CHEMBL421954 |
IUPHAR | N/A |
BindingDB | 50055484 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 550.0 nM | PMID8978857 | BindingDB,ChEMBL |
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