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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
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GPCR

Name	Platelet-activating factor receptor
Species	Cavia porcellus (Guinea pig)
Gene	PTAFR
Synonym	PAF-R PAFr
Disease	N/A for non-human GPCRs
Length	342
Amino acid sequence	MELNSSSRVDSEFRYTLFPIVYSIIFVLGIIANGYVLWVFARLYPSKKLNEIKIFMVNLTVADLLFLITLPLWIVYYSNQGNWFLPKFLCNLAGCLFFINTYCSVAFLGVITYNRFQAVKYPIKTAQATTRKRGIALSLVIWVAIVAAASYFLVMDSTNVVSNKAGSGNITRCFEHYEKGSKPVLIIHICIVLGFFIVFLLILFCNLVIIHTLLRQPVKQQRNAEVRRRALWMVCTVLAVFVICFVPHHMVQLPWTLAELGMWPSSNHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKFRKHLSEKLNIMRSSQKCSRVTTDTGTEMAIPINHTPVNPIKN
UniProt	P21556
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5136
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL318908
Molecular formula	C27H27N5O2
IUPAC name	2-[4-[2-(benzhydrylideneamino)oxyacetyl]piperazin-1-yl]-2-(2-methylpyridin-3-yl)acetonitrile
Molecular weight	453.546
Hydrogen bond acceptor	6
Hydrogen bond donor	0
XlogP	4.0
Synonyms	SCHEMBL9575064 [4-(2-Benzhydrylideneaminooxy-acetyl)-piperazin-1-yl]-(2-methyl-pyridin-3-yl)-acetonitrile BDBM50045973
Inchi Key	AUPLSCMPTRAIEA-UHFFFAOYSA-N
Inchi ID	InChI=1S/C27H27N5O2/c1-21-24(13-8-14-29-21)25(19-28)31-15-17-32(18-16-31)26(33)20-34-30-27(22-9-4-2-5-10-22)23-11-6-3-7-12-23/h2-14,25H,15-18,20H2,1H3
PubChem CID	10343902
ChEMBL	CHEMBL318908
IUPHAR	N/A
BindingDB	50045973
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	87.0 nM	PMID8411016	BindingDB,ChEMBL

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