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| Name | Endothelin receptor type B |
|---|---|
| Species | Rattus norvegicus (Rat) |
| Gene | Ednrb |
| Synonym | HSCR ETB receptor ET-BR ET-B Endothelin receptor non-selective type [ Show all ] |
| Disease | N/A for non-human GPCRs |
| Length | 442 |
| Amino acid sequence | MQSSASRCGRALVALLLACGLLGVWGEKRGFPPAQATPSLLGTKEVMTPPTKTSWTRGSNSSLMRSSAPAEVTKGGRVAGVPPRSFPPPCQRKIEINKTFKYINTIVSCLVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLALGDLLHIIIDIPINAYKLLAGDWPFGAEMCKLVPFIQKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEAIGFDVITSDYKGKPLRVCMLNPFQKTAFMQFYKTAKDWWLFSFYFCLPLAITAIFYTLMTCEMLRKKSGMQIALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTLYDQSNPQRCELLSFLLVLDYIGINMASLNSCINPIALYLVSKRFKNCFKSCLCCWCQTFEEKQSLEEKQSCLKFKANDHGYDNFRSSNKYSSS |
| UniProt | P21451 |
| Protein Data Bank | N/A |
| GPCR-HGmod model | N/A |
| 3D structure model | No available structures or models |
| BioLiP | N/A |
| Therapeutic Target Database | N/A |
| ChEMBL | CHEMBL4631 |
| IUPHAR | 220 |
| DrugBank | N/A |
You can:
| GLASS ID | Molecule | Formula | Molecular weight | H-bond acceptor / donor | XlogP | Lipinski's druglikeness |
|---|---|---|---|---|---|---|
| 2911 |  CHEMBL287819 | C33H30N6OS | 558.704 | 7 / 0 | 7.3 | No |
| 3363 |  CHEMBL367444 | C29H33N5O7S3 | 659.791 | 13 / 2 | 4.9 | No |
| 5469 |  CHEMBL348685 | C20H22N2O3S2 | 402.527 | 6 / 1 | 4.6 | Yes |
| 5963 |  CHEMBL315280 | C27H21ClN2O7 | 520.922 | 8 / 2 | 5.3 | No |
| 6925 |  CHEMBL174235 | C24H18N2O5 | 414.417 | 7 / 1 | 4.6 | Yes |
| 7894 |  CHEMBL38270 | C28H21K2NO7 | 561.673 | 8 / 0 | N/A | No |
| 8625 |  CHEMBL94525 | C50H66N8O10 | 939.124 | 11 / 10 | 2.3 | No |
| 8655 |  CHEMBL151525 | C23H26N2O5S | 442.53 | 7 / 1 | 5.6 | No |
| 10237 |  CHEMBL414082 | C55H73N7O10 | 992.228 | 10 / 9 | 8.2 | No |
| 11839 |  CHEMBL146845 | C24H31N3O3S | 441.59 | 6 / 2 | 6.1 | No |
| 12360 |  CHEMBL94141 | C23H21NO4S | 407.484 | 6 / 1 | 4.5 | Yes |
| 12362 |  CHEMBL94071 | C23H21NO4S | 407.484 | 6 / 1 | 4.5 | Yes |
| 12363 |  CHEMBL90320 | C23H21NO4S | 407.484 | 6 / 1 | 4.5 | Yes |
| 13420 |  CHEMBL323331 | C51H67N7O10 | 938.136 | 10 / 9 | 6.6 | No |
| 13541 |  CHEMBL172030 | C31H32N6O7S3 | 696.812 | 14 / 2 | 5.2 | No |
| 16641 |  CID 44270771 | C108H161N25O32S5 | 2481.92 | 40 / 36 | -5.5 | No |
| 17024 |  CHEMBL174229 | C20H15NO4S | 365.403 | 6 / 1 | 4.0 | Yes |
| 18734 |  CHEMBL149050 | C20H22N2O5S2 | 434.525 | 7 / 1 | 3.4 | Yes |
| 19650 |  CHEMBL434082 | C21H24N2O3S | 384.494 | 5 / 1 | 5.2 | No |
| 20440 |  CHEMBL172297 | C31H36N4O7S3 | 672.83 | 12 / 2 | 6.1 | No |
| 23495 |  BDBM50284278 | C109H159N27O32S5 | 2519.93 | 41 / 37 | -6.7 | No |
| 24822 |  CHEMBL10733 | C25H19ClO6 | 450.871 | 6 / 1 | 4.7 | Yes |
| 442643 |  CHEMBL3400988 | C26H24O7 | 448.471 | 7 / 1 | 4.2 | Yes |
| 25284 |  CHEMBL88011 | C24H23ClN2O6S | 502.966 | 8 / 2 | 4.9 | No |
| 25430 |  CHEMBL41087 | C24H20O6 | 404.418 | 6 / 2 | 4.1 | Yes |
| 25615 |  CHEMBL343867 | C20H23N3O3S | 385.482 | 6 / 2 | 4.1 | Yes |
| 27711 |  CHEMBL265116 | C53H63N7O10 | 958.126 | 10 / 9 | 6.4 | No |
| 28906 |  CHEMBL86489 | C28H26N4O4 | 482.54 | 5 / 3 | 4.1 | Yes |
| 30261 |  CHEMBL327350 | C49H65N7O8 | 880.1 | 8 / 8 | 5.8 | No |
| 30616 |  CHEMBL359152 | C22H26N2O4S | 414.52 | 6 / 1 | 4.9 | Yes |
| 30944 |  CHEMBL92965 | C27H25NO4S | 459.56 | 6 / 1 | 5.4 | No |
| 31730 |  CHEMBL91753 | C25H24N2O4S | 448.537 | 6 / 2 | 4.7 | Yes |
| 33579 |  CHEMBL149060 | C20H22N2O3S | 370.467 | 5 / 1 | 4.8 | Yes |
| 34724 |  CHEMBL105490 | C21H24N2O3S | 384.494 | 5 / 1 | 4.9 | Yes |
| 34794 |  CHEMBL2369710 | C43H58N8O9 | 830.984 | 9 / 8 | 2.7 | No |
| 34795 |  CHEMBL2369709 | C43H58N8O9 | 830.984 | 9 / 8 | 2.7 | No |
| 37405 |  CHEMBL147908 | C43H57N7O12 | 863.966 | 12 / 10 | 2.8 | No |
| 40176 |  CHEMBL148853 | C22H26N2O4S | 414.52 | 6 / 1 | 5.2 | No |
| 41183 |  CHEMBL1793929 | C51H68N8O9 | 937.152 | 10 / 9 | 3.1 | No |
| 42202 |  CHEMBL315752 | C24H25ClN2O4 | 440.924 | 5 / 1 | 6.1 | No |
| 42639 |  CHEMBL288874 | C36H32N2O3 | 540.663 | 4 / 1 | 7.9 | No |
| 43381 |  CID 23427740 | C34H27Br4N4NaO11S | 1042.27 | 13 / 5 | N/A | No |
| 45342 |  CHEMBL2296900 | C17H12N2O5 | 324.292 | 7 / 1 | 3.3 | Yes |
| 46195 |  CHEMBL312854 | C28H21ClN2O8 | 548.932 | 9 / 2 | 4.7 | No |
| 49469 |  CHEMBL329170 | C49H61N7O12 | 940.064 | 12 / 10 | 4.3 | No |
| 50456 |  CHEMBL283037 | C22H21F3N2O5 | 450.414 | 9 / 1 | 4.1 | Yes |
| 54163 |  CHEMBL2296899 | C17H12N2O4S | 340.353 | 7 / 1 | 3.9 | Yes |
| 54577 |  CHEMBL37338 | C27H19ClKNO7 | 543.997 | 8 / 0 | N/A | No |
| 59780 |  CHEMBL359332 | C19H21N3O3S | 371.455 | 6 / 1 | 3.7 | Yes |
| 60279 |  CHEMBL1791279 | C44H61N7O10 | 848.011 | 10 / 9 | 3.3 | No |
| 60281 |  CHEMBL1791272 | C44H61N7O10 | 848.011 | 10 / 9 | 3.3 | No |
| 60283 |  CHEMBL273391 | C44H61N7O10 | 848.011 | 10 / 9 | 3.3 | No |
| 60285 |  CHEMBL86814 | C44H61N7O10 | 848.011 | 10 / 9 | 3.3 | No |
| 60308 |  CHEMBL421365 | C23H22O4S | 394.485 | 5 / 1 | 4.6 | Yes |
| 63323 |  CHEMBL2370245 | C44H51N7O10S2 | 902.051 | 12 / 9 | 3.2 | No |
| 63580 |  CHEMBL356972 | C22H25N3O4S | 427.519 | 7 / 1 | 4.9 | Yes |
| 64015 |  BDBM50284276 | C108H160N26O33S5 | 2510.92 | 41 / 37 | -7.6 | No |
| 64389 |  CHEMBL367958 | C27H36N6O8S2 | 636.739 | 14 / 2 | 2.8 | No |
| 64870 |  CID 44368824 | C76H106N16O18S2 | 1595.9 | 22 / 19 | 1.8 | No |
| 65113 |  CHEMBL315622 | C25H18Cl2N2O4 | 481.329 | 5 / 1 | 6.3 | No |
| 66136 |  CHEMBL269428 | C54H67N7O9 | 958.17 | 10 / 9 | 3.9 | No |
| 67187 |  CHEMBL319660 | C49H63N7O10 | 910.082 | 10 / 9 | 5.8 | No |
| 67189 |  CHEMBL315841 | C49H63N7O10 | 910.082 | 10 / 9 | 5.8 | No |
| 68514 |  CHEMBL343477 | C28H29N3O4S | 503.617 | 6 / 2 | 6.0 | No |
| 70813 |  CHEMBL92353 | C24H22N2O4 | 402.45 | 6 / 1 | 3.8 | Yes |
| 70822 |  CHEMBL405178 | C56H69N7O10 | 1000.21 | 10 / 9 | 7.8 | No |
| 553626 |  142569-99-1 | C86H117N17O27 | 1820.97 | 28 / 23 | 2.1 | No |
| 71673 |  CHEMBL2370246 | C50H63N7O8 | 890.095 | 8 / 8 | 6.6 | No |
| 71864 |  CHEMBL431218 | C46H68N8O8 | 861.098 | 9 / 9 | 1.7 | No |
| 72078 |  CHEMBL346853 | C20H22N2O4S | 386.466 | 6 / 1 | 4.1 | Yes |
| 74323 |  CHEMBL149152 | C23H25LiN2O6S | 464.461 | 8 / 1 | N/A | N/A |
| 74736 |  CHEMBL35527 | C28H21ClKNO9 | 590.022 | 10 / 1 | N/A | No |
| 74944 |  CHEMBL89416 | C39H58N8O10 | 798.939 | 11 / 9 | 2.7 | No |
| 77085 |  CHEMBL1791277 | C39H53N9O12 | 839.904 | 13 / 11 | 0.7 | No |
| 77958 |  CHEMBL26474 | C26H21ClN2O5 | 476.913 | 6 / 1 | 5.7 | No |
| 78789 |  CHEMBL35744 | C28H22KNO6 | 507.583 | 7 / 0 | N/A | No |
| 80885 |  CHEMBL347982 | C22H25N3O4S | 427.519 | 6 / 2 | 4.4 | Yes |
| 82566 |  CHEMBL355413 | C23H17NO6 | 403.39 | 7 / 1 | 4.2 | Yes |
| 82920 |  CHEMBL3144735 | C20H16ClF3N2O4 | 440.803 | 8 / 1 | 4.6 | Yes |
| 82923 |  CHEMBL281865 | C26H22N2O5 | 442.471 | 6 / 1 | 5.1 | No |
| 86849 |  CHEMBL3144803 | C19H15Cl2F3N2O2 | 431.236 | 6 / 1 | 5.5 | No |
| 90499 |  CHEMBL93097 | C26H23NO6 | 445.471 | 7 / 1 | 4.6 | Yes |
| 91083 |  CHEMBL1793925 | C51H68N8O9 | 937.152 | 10 / 9 | 3.1 | No |
| 93444 |  CHEMBL347958 | C17H17N3O3S | 343.401 | 6 / 2 | 2.6 | Yes |
| 94005 |  CHEMBL86505 | C28H23ClN2O8 | 550.948 | 9 / 2 | 5.2 | No |
| 94947 |  CHEMBL315384 | C43H54N6O8 | 782.939 | 8 / 8 | 4.9 | No |
| 95368 |  CHEMBL345551 | C22H26N2O3S | 398.521 | 5 / 1 | 5.4 | No |
| 98129 |  Bosentan | C27H29N5O6S | 551.618 | 11 / 2 | 3.8 | No |
| 98296 |  CHEMBL316187 | C27H23ClN2O6 | 506.939 | 7 / 1 | 5.7 | No |
| 98948 |  CHEMBL1793926 | C51H67N7O10 | 938.136 | 10 / 8 | 6.3 | No |
| 100006 |  CHEMBL3144737 | C21H17F5N2O4 | 456.369 | 10 / 1 | 4.7 | Yes |
| 100814 |  CHEMBL313984 | C47H59N7O10 | 882.028 | 10 / 9 | 4.5 | No |
| 100817 |  CHEMBL146155 | C47H59N7O10 | 882.028 | 10 / 9 | 4.5 | No |
| 100820 |  CHEMBL317099 | C47H59N7O10 | 882.028 | 10 / 9 | 4.5 | No |
| 101455 |  CHEMBL330489 | C28H34N4O5 | 506.603 | 5 / 5 | 3.3 | No |
| 104593 |  CHEMBL3144602 | C20H15F3N2O5 | 420.344 | 9 / 1 | 3.9 | Yes |
| 105309 |  CHEMBL149391 | C21H24N2O4S | 400.493 | 6 / 2 | 4.9 | Yes |
| 105588 |  CHEMBL356618 | C28H30N2O4S | 490.618 | 6 / 1 | 6.7 | No |
| 106736 |  CHEMBL172071 | C26H33N5O7S2 | 591.698 | 12 / 2 | 3.3 | No |
| 445921 |  CHEMBL3400984 | C25H24O5 | 404.462 | 5 / 1 | 4.4 | Yes |
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