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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Endothelin receptor type B
Species	Rattus norvegicus (Rat)
Gene	Ednrb
Synonym	HSCR ETB receptor ET-BR ET-B Endothelin receptor non-selective type endothelin B receptor HSCR2 [ Show all ]
Disease	N/A for non-human GPCRs
Length	442
Amino acid sequence	MQSSASRCGRALVALLLACGLLGVWGEKRGFPPAQATPSLLGTKEVMTPPTKTSWTRGSNSSLMRSSAPAEVTKGGRVAGVPPRSFPPPCQRKIEINKTFKYINTIVSCLVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLALGDLLHIIIDIPINAYKLLAGDWPFGAEMCKLVPFIQKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEAIGFDVITSDYKGKPLRVCMLNPFQKTAFMQFYKTAKDWWLFSFYFCLPLAITAIFYTLMTCEMLRKKSGMQIALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTLYDQSNPQRCELLSFLLVLDYIGINMASLNSCINPIALYLVSKRFKNCFKSCLCCWCQTFEEKQSLEEKQSCLKFKANDHGYDNFRSSNKYSSS
UniProt	P21451
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4631
IUPHAR	220
DrugBank	N/A

Ligand

Name	CHEMBL35744
Molecular formula	C28H22KNO6
IUPAC name	potassium;1-[(6-ethenyl-1,3-benzodioxol-5-yl)methyl]-3-[(4-methoxyphenyl)methyl]-4-oxoquinoline-2-carboxylate
Molecular weight	507.583
Hydrogen bond acceptor	7
Hydrogen bond donor	0
XlogP	None
Synonyms	1-(6-Vinyl-1,3-benzodioxole-5-ylmethyl)-3-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-2-carboxylic acid potassium salt
Inchi Key	FHYFUTFYKIRZET-UHFFFAOYSA-M
Inchi ID	InChI=1S/C28H23NO6.K/c1-3-18-13-24-25(35-16-34-24)14-19(18)15-29-23-7-5-4-6-21(23)27(30)22(26(29)28(31)32)12-17-8-10-20(33-2)11-9-17;/h3-11,13-14H,1,12,15-16H2,2H3,(H,31,32);/q;+1/p-1
PubChem CID	44283787
ChEMBL	CHEMBL35744
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. Partition coefficient log P of this ligand is not available.

Experimental Data

Parameter	Value	Reference	Database source
Binding affinity	70.0 nM	PMID10888339	ChEMBL

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