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GPCR

NameEndothelin receptor type B
SpeciesRattus norvegicus (Rat)
GeneEdnrb
SynonymHSCR
ETB receptor
ET-BR
ET-B
Endothelin receptor non-selective type
[ Show all ]
DiseaseN/A for non-human GPCRs
Length442
Amino acid sequenceMQSSASRCGRALVALLLACGLLGVWGEKRGFPPAQATPSLLGTKEVMTPPTKTSWTRGSNSSLMRSSAPAEVTKGGRVAGVPPRSFPPPCQRKIEINKTFKYINTIVSCLVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLALGDLLHIIIDIPINAYKLLAGDWPFGAEMCKLVPFIQKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEAIGFDVITSDYKGKPLRVCMLNPFQKTAFMQFYKTAKDWWLFSFYFCLPLAITAIFYTLMTCEMLRKKSGMQIALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTLYDQSNPQRCELLSFLLVLDYIGINMASLNSCINPIALYLVSKRFKNCFKSCLCCWCQTFEEKQSLEEKQSCLKFKANDHGYDNFRSSNKYSSS
UniProtP21451
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4631
IUPHAR220
DrugBankN/A

Ligand

NameCHEMBL345551
Molecular formulaC22H26N2O3S
IUPAC nameN-(3,4-dimethyl-1,2-oxazol-5-yl)-2-[4-(3-methylbutyl)phenyl]benzenesulfonamide
Molecular weight398.521
Hydrogen bond acceptor5
Hydrogen bond donor1
XlogP5.4
SynonymsSCHEMBL6776391
4''-(3-Methyl-butyl)-biphenyl-2-sulfonic acid (3,4-dimethyl-isoxazol-5-yl)-amide
BDBM50068726
Inchi KeyGFTLLUJPMHVZEC-UHFFFAOYSA-N
Inchi IDInChI=1S/C22H26N2O3S/c1-15(2)9-10-18-11-13-19(14-12-18)20-7-5-6-8-21(20)28(25,26)24-22-16(3)17(4)23-27-22/h5-8,11-15,24H,9-10H2,1-4H3
PubChem CID10548904
ChEMBLCHEMBL345551
IUPHARN/A
BindingDB50068726
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
Ki30000.0 nMPMID9857090BindingDB,ChEMBL

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