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GPCR

NameEndothelin receptor type B
SpeciesRattus norvegicus (Rat)
GeneEdnrb
SynonymHSCR
ETB receptor
ET-BR
ET-B
Endothelin receptor non-selective type
[ Show all ]
DiseaseN/A for non-human GPCRs
Length442
Amino acid sequenceMQSSASRCGRALVALLLACGLLGVWGEKRGFPPAQATPSLLGTKEVMTPPTKTSWTRGSNSSLMRSSAPAEVTKGGRVAGVPPRSFPPPCQRKIEINKTFKYINTIVSCLVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLALGDLLHIIIDIPINAYKLLAGDWPFGAEMCKLVPFIQKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEAIGFDVITSDYKGKPLRVCMLNPFQKTAFMQFYKTAKDWWLFSFYFCLPLAITAIFYTLMTCEMLRKKSGMQIALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTLYDQSNPQRCELLSFLLVLDYIGINMASLNSCINPIALYLVSKRFKNCFKSCLCCWCQTFEEKQSLEEKQSCLKFKANDHGYDNFRSSNKYSSS
UniProtP21451
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4631
IUPHAR220
DrugBankN/A

Ligand

NameCHEMBL149060
Molecular formulaC20H22N2O3S
IUPAC nameN-(4-methyl-1,2-oxazol-5-yl)-2-[4-(2-methylpropyl)phenyl]benzenesulfonamide
Molecular weight370.467
Hydrogen bond acceptor5
Hydrogen bond donor1
XlogP4.8
SynonymsBDBM50068671
N-(4-Methylisoxazole-5-yl)-4'-(2-methylpropyl)-1,1'-biphenyl-2-sulfonamide
4''-Isobutyl-biphenyl-2-sulfonic acid (4-methyl-isoxazol-5-yl)-amide
SCHEMBL6769994
Inchi KeyBVBZNVTXDHYSOW-UHFFFAOYSA-N
Inchi IDInChI=1S/C20H22N2O3S/c1-14(2)12-16-8-10-17(11-9-16)18-6-4-5-7-19(18)26(23,24)22-20-15(3)13-21-25-20/h4-11,13-14,22H,12H2,1-3H3
PubChem CID10737908
ChEMBLCHEMBL149060
IUPHARN/A
BindingDB50068671
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki100000.0 nMPMID9857090BindingDB,ChEMBL

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