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GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	AMG-076 free base
Molecular formula	C26H33F3N2O2
IUPAC name	1-[2-[(4aR,11R,11aS)-11-methyl-9-(trifluoromethyl)-1,3,4,4a,5,6,11,11a-octahydropyrido[4,3-b]carbazol-2-yl]ethyl]cyclohexane-1-carboxylic acid
Molecular weight	462.557
Hydrogen bond acceptor	6
Hydrogen bond donor	2
XlogP	3.8
Synonyms	1-(2-((4aR,11R,11aS)-11-methyl-9-(trifluoromethyl)-3,4,4a,5,11,11a-hexahydro-1H-pyrido[4,3-b]carbazol-2(6H)-yl)ethyl)cyclohexanecarboxylic acid D0X4MC SCHEMBL2742722 CHEMBL2032049 DTXSID70219485 BDBM50383522 UNII-HX4T7JEV3D (4aR)-2-[2-(1-Carboxycyclohexyl)ethyl]-2,3,4,4abeta,5,6,11,11aalpha-octahydro-9-(trifluoromethyl)-11alpha-methyl-1H-pyrido[4,3-b]carbazole Cyclohexanecarboxylic acid, 1-(2-((4aR,11R,11aS)-1,3,4,4a,5,6,11,11a-octahydro-11-methyl-9-(trifluoromethyl)-2H-pyrido(4,3-b)carbazol-2-yl)ethyl)- 693823-79-9 HX4T7JEV3D [ Show all ]
Inchi Key	WAOZNBXSEVIAGX-MBOZVWFJSA-N
Inchi ID	InChI=1S/C26H33F3N2O2/c1-16-20-15-31(12-10-25(24(32)33)8-3-2-4-9-25)11-7-17(20)13-22-23(16)19-14-18(26(27,28)29)5-6-21(19)30-22/h5-6,14,16-17,20,30H,2-4,7-13,15H2,1H3,(H,32,33)/t16-,17-,20-/m1/s1
PubChem CID	10004545
ChEMBL	CHEMBL2032049
IUPHAR	N/A
BindingDB	50383522
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
368780	5-hydroxytryptamine receptor 1A	P08908	HTR1A	Homo sapiens (Human)	422
368776	5-hydroxytryptamine receptor 2A	P28223	HTR2A	Homo sapiens (Human)	471
368772	5-hydroxytryptamine receptor 2C	P28335	HTR2C	Homo sapiens (Human)	458
368781	Alpha-2A adrenergic receptor	P08913	ADRA2A	Homo sapiens (Human)	450
368783	Alpha-2C adrenergic receptor	P18825	ADRA2C	Homo sapiens (Human)	462
368774	D(1A) dopamine receptor	P21728	DRD1	Homo sapiens (Human)	446
368782	D(2) dopamine receptor	P14416	DRD2	Homo sapiens (Human)	443
368775	Melanin-concentrating hormone receptor 1	Q99705	MCHR1	Homo sapiens (Human)	422
368779	Melanin-concentrating hormone receptor 1	P97639	Mchr1	Rattus norvegicus (Rat)	353
368784	Melanin-concentrating hormone receptor 1	Q8MJ89	MCHR1	Macaca mulatta (Rhesus macaque)	388
368786	Melanin-concentrating hormone receptor 1	Q8JZL2	Mchr1	Mus musculus (Mouse)	353
368785	Melanin-concentrating hormone receptor 2	Q969V1	MCHR2	Homo sapiens (Human)	340
368778	Mu-type opioid receptor	P35372	OPRM1	Homo sapiens (Human)	400
368773	Muscarinic acetylcholine receptor M2	P08172	CHRM2	Homo sapiens (Human)	466
368777	Muscarinic acetylcholine receptor M3	P20309	CHRM3	Homo sapiens (Human)	590

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