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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Melanin-concentrating hormone receptor 1
Species	Macaca mulatta (Rhesus macaque)
Gene	MCHR1
Synonym	G-protein coupled receptor 24 MCH receptor 1 MCH-1R MCH-R1 MCH1R MCHR MCHR-1 [ Show all ]
Disease	N/A for non-human GPCRs
Length	388
Amino acid sequence	ACAPGQGGRRWRLPQPAWVEGSSAWLWEPATGTGWMDLEASLLPTGPNTSNTSDGPDNLTSAGSPPRSGSVSYINIIMPSVFGTICLLGIIGNSMVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT
UniProt	Q8MJ89
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2029193
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	AMG-076 free base
Molecular formula	C26H33F3N2O2
IUPAC name	1-[2-[(4aR,11R,11aS)-11-methyl-9-(trifluoromethyl)-1,3,4,4a,5,6,11,11a-octahydropyrido[4,3-b]carbazol-2-yl]ethyl]cyclohexane-1-carboxylic acid
Molecular weight	462.557
Hydrogen bond acceptor	6
Hydrogen bond donor	2
XlogP	3.8
Synonyms	(4aR)-2-[2-(1-Carboxycyclohexyl)ethyl]-2,3,4,4abeta,5,6,11,11aalpha-octahydro-9-(trifluoromethyl)-11alpha-methyl-1H-pyrido[4,3-b]carbazole Cyclohexanecarboxylic acid, 1-(2-((4aR,11R,11aS)-1,3,4,4a,5,6,11,11a-octahydro-11-methyl-9-(trifluoromethyl)-2H-pyrido(4,3-b)carbazol-2-yl)ethyl)- 693823-79-9 HX4T7JEV3D 1-(2-((4aR,11R,11aS)-11-methyl-9-(trifluoromethyl)-3,4,4a,5,11,11a-hexahydro-1H-pyrido[4,3-b]carbazol-2(6H)-yl)ethyl)cyclohexanecarboxylic acid D0X4MC SCHEMBL2742722 CHEMBL2032049 DTXSID70219485 BDBM50383522 UNII-HX4T7JEV3D [ Show all ]
Inchi Key	WAOZNBXSEVIAGX-MBOZVWFJSA-N
Inchi ID	InChI=1S/C26H33F3N2O2/c1-16-20-15-31(12-10-25(24(32)33)8-3-2-4-9-25)11-7-17(20)13-22-23(16)19-14-18(26(27,28)29)5-6-21(19)30-22/h5-6,14,16-17,20,30H,2-4,7-13,15H2,1H3,(H,32,33)/t16-,17-,20-/m1/s1
PubChem CID	10004545
ChEMBL	CHEMBL2032049
IUPHAR	N/A
BindingDB	50383522
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	0.8 nM	PMID22542010	BindingDB,ChEMBL

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