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GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	A-123189
Molecular formula	C26H28N4O3S
IUPAC name	3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-5-(3-methylphenyl)-1H-thieno[2,3-d]pyrimidine-2,4-dione
Molecular weight	476.595
Hydrogen bond acceptor	6
Hydrogen bond donor	1
XlogP	4.2
Synonyms	A123189 3-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-5-m-tolyl-1H-thieno[2,3-d]pyrimidine-2,4-dione CHEMBL13856 A 123189 SCHEMBL7834335 3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-5-(3-methylphenyl)-1H-thieno[3,2-e]pyrimidine-2,4-dione BDBM50099325 D0EO4F 3-[2-[4-(2-Methoxyphenyl)piperazino]ethyl]-5-m-tolyl-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidine-2,4-dione GTPL491 [ Show all ]
Inchi Key	PANBMHHKBRMYAL-UHFFFAOYSA-N
Inchi ID	InChI=1S/C26H28N4O3S/c1-18-6-5-7-19(16-18)20-17-34-24-23(20)25(31)30(26(32)27-24)15-12-28-10-13-29(14-11-28)21-8-3-4-9-22(21)33-2/h3-9,16-17H,10-15H2,1-2H3,(H,27,32)
PubChem CID	9891167
ChEMBL	CHEMBL13856
IUPHAR	491
BindingDB	50099325
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
254920	Alpha-1A adrenergic receptor	P35348	ADRA1A	Homo sapiens (Human)	466
254921	Alpha-1A adrenergic receptor	P43140	Adra1a	Rattus norvegicus (Rat)	466
254925	Alpha-1A adrenergic receptor	P18130	ADRA1A	Bos taurus (Bovine)	466
254919	Alpha-1B adrenergic receptor	P35368	ADRA1B	Homo sapiens (Human)	520
254923	Alpha-1B adrenergic receptor	P15823	Adra1b	Rattus norvegicus (Rat)	515
254917	Alpha-1D adrenergic receptor	P25100	ADRA1D	Homo sapiens (Human)	572
254922	Alpha-1D adrenergic receptor	P23944	Adra1d	Rattus norvegicus (Rat)	561
254927	Alpha-2A adrenergic receptor	P08913	ADRA2A	Homo sapiens (Human)	450
254924	Alpha-2B adrenergic receptor	P19328	Adra2b	Rattus norvegicus (Rat)	453
254918	Alpha-2C adrenergic receptor	P18825	ADRA2C	Homo sapiens (Human)	462
254916	D(1A) dopamine receptor	P18901	Drd1	Rattus norvegicus (Rat)	446
254926	D(2) dopamine receptor	P61169	Drd2	Rattus norvegicus (Rat)	444

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