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GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	64022-27-1
Molecular formula	C8H11ClN4
IUPAC name	2-chloro-6-piperazin-1-ylpyrazine
Molecular weight	198.654
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	0.5
Synonyms	MK212 SCHEMBL255453 6''-Chloro-3,4,5,6-tetrahydro-2H-[1,2'']bipyrazinyl(MK-212) AC1Q3PR0 GTPL165 NSC-317326 ZINC1571800 2-Chloro-6-(1-piperazinyl)pyrazine 61655-58-1 (mono-hydrochloride) Biomol-NT_000130 CTK8D5384 L001055 PDSP2_000725 AB21523 C90119 DTXSID80214007 MK 212 NCGC00024891-01 Tocris-0941 1-(6-chloro-2-pyrazinyl)piperazine 6-Chloro-2-(1-piperazinyl)pyrazine AKOS006229696 CHEMBL269521 KB-199285 NSC317326 2-chloro-6-(piperazin-1-yl)pyrazine 62C3N7238U BPBio1_000111 D02ESW LS-127601 MK-212 Pyrazine, 2-chloro-6-(1-piperazinyl)- 6''-Chloro-3,4,5,6-tetrahydro-2H-[1,2'']bipyrazinyl AC1L334H CHEBI:92360 FT-0707954 NCGC00024891-02 UNII-62C3N7238U 6-chloro-2-[1-piperazinyl]-pyrazine BDBM50017452 CJAWPFJGFFNXQI-UHFFFAOYSA-N L-630,571 PDSP1_000735 2-chloro-6-piperazin-1-ylpyrazine BRD-K19554809-001-01-1 DB12111 M-3644 [ Show all ]
Inchi Key	CJAWPFJGFFNXQI-UHFFFAOYSA-N
Inchi ID	InChI=1S/C8H11ClN4/c9-7-5-11-6-8(12-7)13-3-1-10-2-4-13/h5-6,10H,1-4H2
PubChem CID	107992
ChEMBL	CHEMBL269521
IUPHAR	165
BindingDB	50017452
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
43156	5-hydroxytryptamine receptor 1A	P08908	HTR1A	Homo sapiens (Human)	422
43160	5-hydroxytryptamine receptor 1A	P19327	Htr1a	Rattus norvegicus (Rat)	422
43158	5-hydroxytryptamine receptor 1B	P28564	Htr1b	Rattus norvegicus (Rat)	386
43151	5-hydroxytryptamine receptor 2A	P28223	HTR2A	Homo sapiens (Human)	471
555641	5-hydroxytryptamine receptor 2A	P14842	Htr2a	Rattus norvegicus (Rat)	471
43153	5-hydroxytryptamine receptor 2B	P41595	HTR2B	Homo sapiens (Human)	481
43159	5-hydroxytryptamine receptor 2B	P30994	Htr2b	Rattus norvegicus (Rat)	479
43152	5-hydroxytryptamine receptor 2C	P28335	HTR2C	Homo sapiens (Human)	458
43154	5-hydroxytryptamine receptor 2C	P08909	Htr2c	Rattus norvegicus (Rat)	460
43162	Alpha-2A adrenergic receptor	P08913	ADRA2A	Homo sapiens (Human)	450
43161	Alpha-2B adrenergic receptor	P19328	Adra2b	Rattus norvegicus (Rat)	453
43155	D(1A) dopamine receptor	P18901	Drd1	Rattus norvegicus (Rat)	446
43157	D(2) dopamine receptor	P61169	Drd2	Rattus norvegicus (Rat)	444

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