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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	D(1A) dopamine receptor
Species	Rattus norvegicus (Rat)
Gene	Drd1
Synonym	D1 receptor D1A DADR dopamine D1 receptor Dopamine-1A receptor Gpcr15 [ Show all ]
Disease	N/A for non-human GPCRs
Length	446
Amino acid sequence	MAPNTSTMDEAGLPAERDFSFRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPLGPFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFQYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTWPLDGNFTSLEDTEDDNCDTRLSRTYAISSSLISFYIPVAIMIVTYTSIYRIAQKQIRRISALERAAVHAKNCQTTAGNGNPVECAQSESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFISNCMVPFCGSEETQPFCIDSITFDVFVWFGWANSSLNPIIYAFNADFQKAFSTLLGCYRLCPTTNNAIETVSINNNGAVVFSSHHEPRGSISKDCNLVYLIPHAVGSSEDLKKEEAGGIAKPLEKLSPALSVILDYDTDVSLEKIQPVTHSGQHST
UniProt	P18901
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL265
IUPHAR	214
DrugBank	N/A

Ligand

Name	64022-27-1
Molecular formula	C8H11ClN4
IUPAC name	2-chloro-6-piperazin-1-ylpyrazine
Molecular weight	198.654
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	0.5
Synonyms	AB21523 C90119 DTXSID80214007 MK 212 PDSP2_000725 6-Chloro-2-(1-piperazinyl)pyrazine AKOS006229696 CHEMBL269521 KB-199285 NCGC00024891-01 Tocris-0941 1-(6-chloro-2-pyrazinyl)piperazine 2-chloro-6-(piperazin-1-yl)pyrazine 62C3N7238U BPBio1_000111 D02ESW LS-127601 NSC317326 6''-Chloro-3,4,5,6-tetrahydro-2H-[1,2'']bipyrazinyl AC1L334H CHEBI:92360 FT-0707954 MK-212 Pyrazine, 2-chloro-6-(1-piperazinyl)- 6-chloro-2-[1-piperazinyl]-pyrazine BDBM50017452 CJAWPFJGFFNXQI-UHFFFAOYSA-N L-630,571 NCGC00024891-02 UNII-62C3N7238U 2-chloro-6-piperazin-1-ylpyrazine BRD-K19554809-001-01-1 DB12111 M-3644 PDSP1_000735 6''-Chloro-3,4,5,6-tetrahydro-2H-[1,2'']bipyrazinyl(MK-212) AC1Q3PR0 GTPL165 MK212 SCHEMBL255453 2-Chloro-6-(1-piperazinyl)pyrazine 61655-58-1 (mono-hydrochloride) Biomol-NT_000130 CTK8D5384 L001055 NSC-317326 ZINC1571800 [ Show all ]
Inchi Key	CJAWPFJGFFNXQI-UHFFFAOYSA-N
Inchi ID	InChI=1S/C8H11ClN4/c9-7-5-11-6-8(12-7)13-3-1-10-2-4-13/h5-6,10H,1-4H2
PubChem CID	107992
ChEMBL	CHEMBL269521
IUPHAR	165
BindingDB	50017452
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	<1000.0 nM	PMID2565400	BindingDB,ChEMBL

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