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GPCR

Name	Alpha-2A adrenergic receptor
Species	Homo sapiens (Human)
Gene	ADRA2A
Synonym	alpha2D alpha2A-AR alpha2A-adrenoceptor alpha2A-adrenergic receptor alpha2A Alpha-2AAR Adra-2 Adra-2a ADRA2 ADRA2R Adrenergic alpha 2A receptor adrenergic receptor Alpha-2 adrenergic receptor subtype C10 Alpha-2A adrenoceptor Alpha-2A adrenoreceptor [ Show all ]
Disease	Attention deficit hyperactivity disorder Sexual dysfunction Pain
Length	450
Amino acid sequence	MGSLQPDAGNASWNGTEAPGGGARATPYSLQVTLTLVCLAGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIITVWVISAVISFPPLISIEKKGGGGGPQPAEPRCEINDQKWYVISSCIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDAVAAPPGGTERRPNGLGPERSAGPGGAEAEPLPTQLNGAPGEPAPAGPRDTDALDLEESSSSDHAERPPGPRRPERGPRGKGKARASQVKPGDSLPRRGPGATGIGTPAAGPGEERVGAAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAVGCSVPRTLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV
UniProt	P08913
Protein Data Bank	N/A
GPCR-HGmod model	P08913
3D structure model	This predicted structure model is from GPCR-EXP P08913.
BioLiP	N/A
Therapeutic Target Database	T11448
ChEMBL	CHEMBL1867
IUPHAR	25
DrugBank	BE0000289

Ligand

Name	64022-27-1
Molecular formula	C8H11ClN4
IUPAC name	2-chloro-6-piperazin-1-ylpyrazine
Molecular weight	198.654
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	0.5
Synonyms	CHEMBL269521 KB-199285 NCGC00024891-01 Tocris-0941 1-(6-chloro-2-pyrazinyl)piperazine 6-Chloro-2-(1-piperazinyl)pyrazine AKOS006229696 BPBio1_000111 D02ESW LS-127601 NSC317326 2-chloro-6-(piperazin-1-yl)pyrazine 62C3N7238U CHEBI:92360 FT-0707954 MK-212 Pyrazine, 2-chloro-6-(1-piperazinyl)- 6''-Chloro-3,4,5,6-tetrahydro-2H-[1,2'']bipyrazinyl AC1L334H CJAWPFJGFFNXQI-UHFFFAOYSA-N L-630,571 NCGC00024891-02 UNII-62C3N7238U 6-chloro-2-[1-piperazinyl]-pyrazine BDBM50017452 BRD-K19554809-001-01-1 DB12111 M-3644 PDSP1_000735 2-chloro-6-piperazin-1-ylpyrazine GTPL165 MK212 SCHEMBL255453 6''-Chloro-3,4,5,6-tetrahydro-2H-[1,2'']bipyrazinyl(MK-212) AC1Q3PR0 CTK8D5384 L001055 NSC-317326 ZINC1571800 2-Chloro-6-(1-piperazinyl)pyrazine 61655-58-1 (mono-hydrochloride) Biomol-NT_000130 C90119 DTXSID80214007 MK 212 PDSP2_000725 AB21523 [ Show all ]
Inchi Key	CJAWPFJGFFNXQI-UHFFFAOYSA-N
Inchi ID	InChI=1S/C8H11ClN4/c9-7-5-11-6-8(12-7)13-3-1-10-2-4-13/h5-6,10H,1-4H2
PubChem CID	107992
ChEMBL	CHEMBL269521
IUPHAR	165
BindingDB	50017452
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	153.0 nM	PMID1656026	BindingDB

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