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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	5-hydroxytryptamine receptor 2B
Species	Rattus norvegicus (Rat)
Gene	Htr2b
Synonym	stomach fundus serotonin receptor serotonin receptor 2B 5-HT-2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled 5-HT2F 5-HT2B receptor 5-HT2B 5-HT-2F {ECO:0000303\|PubMed:1331748} Stomach fundus serotonin receptor {ECO:0000303\|PubMed:1505525} [ Show all ]
Disease	N/A for non-human GPCRs
Length	479
Amino acid sequence	MASSYKMSEQSTISEHILQKTCDHLILTDRSGLKAESAAEEMKQTAENQGNTVHWAALLIFAVIIPTIGGNILVILAVSLEKRLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEATWPLPLALCPAWLFLDVLFSTASIMHLCAISLDRYIAIKKPIQANQCNSRTTAFVKITVVWLISIGIAIPVPIKGIEADVVNAHNITCELTKDRFGSFMLFGSLAAFFAPLTIMIVTYFLTIHALRKKAYLVRNRPPQRLTRWTVSTVLQREDSSFSSPEKMVMLDGSHKDKILPNSTDETLMRRMSSAGKKPAQTISNEQRASKVLGIVFLFFLLMWCPFFITNVTLALCDSCNQTTLKTLLQIFVWVGYVSSGVNPLIYTLFNKTFREAFGRYITCNYQATKSVKVLRKCSSTLYFGNSMVENSKFFTKHGIRNGINPAMYQSPVRLRSSTIQSSSIILLNTFLTENDGDKVEDQVSYI
UniProt	P30994
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL323
IUPHAR	7
DrugBank	N/A

Ligand

Name	64022-27-1
Molecular formula	C8H11ClN4
IUPAC name	2-chloro-6-piperazin-1-ylpyrazine
Molecular weight	198.654
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	0.5
Synonyms	GTPL165 MK212 SCHEMBL255453 6''-Chloro-3,4,5,6-tetrahydro-2H-[1,2'']bipyrazinyl(MK-212) AC1Q3PR0 L001055 NSC-317326 ZINC1571800 2-Chloro-6-(1-piperazinyl)pyrazine 61655-58-1 (mono-hydrochloride) Biomol-NT_000130 CTK8D5384 MK 212 PDSP2_000725 AB21523 C90119 DTXSID80214007 KB-199285 NCGC00024891-01 Tocris-0941 1-(6-chloro-2-pyrazinyl)piperazine 6-Chloro-2-(1-piperazinyl)pyrazine AKOS006229696 CHEMBL269521 LS-127601 NSC317326 2-chloro-6-(piperazin-1-yl)pyrazine 62C3N7238U BPBio1_000111 D02ESW FT-0707954 MK-212 Pyrazine, 2-chloro-6-(1-piperazinyl)- 6''-Chloro-3,4,5,6-tetrahydro-2H-[1,2'']bipyrazinyl AC1L334H CHEBI:92360 L-630,571 NCGC00024891-02 UNII-62C3N7238U 6-chloro-2-[1-piperazinyl]-pyrazine BDBM50017452 CJAWPFJGFFNXQI-UHFFFAOYSA-N M-3644 PDSP1_000735 2-chloro-6-piperazin-1-ylpyrazine BRD-K19554809-001-01-1 DB12111 [ Show all ]
Inchi Key	CJAWPFJGFFNXQI-UHFFFAOYSA-N
Inchi ID	InChI=1S/C8H11ClN4/c9-7-5-11-6-8(12-7)13-3-1-10-2-4-13/h5-6,10H,1-4H2
PubChem CID	107992
ChEMBL	CHEMBL269521
IUPHAR	165
BindingDB	50017452
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	<10000.0 nM	PMID7984267	BindingDB
Ki	398.107 nM	PMID8450835	IUPHAR
Ki	407.38 nM	PMID7984267	BindingDB

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