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| Name | Gamma-aminobutyric acid type B receptor subunit 1 |
|---|---|
| Species | Rattus norvegicus (Rat) |
| Gene | Gabbr1 |
| Synonym | Gb1 gamma-aminobutyric acid (GABA) B receptor 1 gamma-aminobutyric acid (GABA) B receptor GABABR1 GABAB1 [ Show all ] |
| Disease | N/A for non-human GPCRs |
| Length | 991 |
| Amino acid sequence | MLLLLLVPLFLRPLGAGGAQTPNATSEGCQIIHPPWEGGIRYRGLTRDQVKAINFLPVDYEIEYVCRGEREVVGPKVRKCLANGSWTDMDTPSRCVRICSKSYLTLENGKVFLTGGDLPALDGARVEFRCDPDFHLVGSSRSVCSQGQWSTPKPHCQVNRTPHSERRAVYIGALFPMSGGWPGGQACQPAVEMALEDVNSRRDILPDYELKLIHHDSKCDPGQATKYLYELLYNDPIKIILMPGCSSVSTLVAEAARMWNLIVLSYGSSSPALSNRQRFPTFFRTHPSATLHNPTRVKLFEKWGWKKIATIQQTTEVFTSTLDDLEERVKEAGIEITFRQSFFSDPAVPVKNLKRQDARIIVGLFYETEARKVFCEVYKERLFGKKYVWFLIGWYADNWFKTYDPSINCTVEEMTEAVEGHITTEIVMLNPANTRSISNMTSQEFVEKLTKRLKRHPEETGGFQEAPLAYDAIWALALALNKTSGGGGRSGVRLEDFNYNNQTITDQIYRAMNSSSFEGVSGHVVFDASGSRMAWTLIEQLQGGSYKKIGYYDSTKDDLSWSKTDKWIGGSPPADQTLVIKTFRFLSQKLFISVSVLSSLGIVLAVVCLSFNIYNSHVRYIQNSQPNLNNLTAVGCSLALAAVFPLGLDGYHIGRSQFPFVCQARLWLLGLGFSLGYGSMFTKIWWVHTVFTKKEEKKEWRKTLEPWKLYATVGLLVGMDVLTLAIWQIVDPLHRTIETFAKEEPKEDIDVSILPQLEHCSSKKMNTWLGELWSFAVSSDVQRRATVGGDSPICVWPAPESIFYGYKGLLLLLGIFLAYETKSVSTEKINDHRAVGMAIYNVAVLCLITAPVTMILSSQQDAAFAFASLAIVFSSYITLVVLFVPKMRRLITRGEWQSETQDTMKTGSSTNNNEEEKSRLLEKENRELEKIIAEKEERVSELRHQLQSRQQLRSRRHPPTPPDPSGGLPRGPSEPPDRLSCDGSRVHLLYK |
| UniProt | Q9Z0U4 |
| Protein Data Bank | N/A |
| GPCR-HGmod model | N/A |
| 3D structure model | No available structures or models |
| BioLiP | N/A |
| Therapeutic Target Database | N/A |
| ChEMBL | CHEMBL2753 |
| IUPHAR | 240 |
| DrugBank | N/A |
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| GLASS ID | Molecule | Formula | Molecular weight | H-bond acceptor / donor | XlogP | Lipinski's druglikeness |
|---|---|---|---|---|---|---|
| 555481 |  diazepam | C16H13ClN2O | 284.743 | 2 / 0 | 3.0 | Yes |
| 1968 |  CHEMBL303580 | C15H18N3O3+ | 288.327 | 5 / 2 | 1.6 | Yes |
| 553280 |  CGP 62349 | C21H28NO6P | 421.43 | 7 / 3 | -1.1 | Yes |
| 11418 |  CID 28560001 | C11H18NO2P | 227.244 | 2 / 1 | 0.2 | Yes |
| 464697 |  Allopregnanolone | C21H34O2 | 318.501 | 2 / 1 | 4.9 | Yes |
| 17927 |  CHEMBL114585 | C8H20NO2P | 193.227 | 3 / 2 | -2.3 | Yes |
| 555563 |  CHEMBL43345 | C17H17NO2 | 267.328 | 3 / 3 | 2.5 | Yes |
| 555575 |  gamma-Acetylenic gaba | C6H9NO2 | 127.143 | 3 / 2 | -3.0 | Yes |
| 29549 |  CHEMBL555181 | C21H22N2O2 | 334.419 | 3 / 2 | 3.2 | Yes |
| 30435 |  CHEMBL544776 | C20H22N2O2 | 322.408 | 3 / 2 | 3.3 | Yes |
| 553417 |  4-aminobutyric acid | C4H9NO2 | 103.121 | 3 / 2 | -3.2 | Yes |
| 443129 |  CHEMBL111858 | C5H15N2O2P | 166.161 | 4 / 3 | -4.9 | Yes |
| 40157 |  CHEMBL112460 | C11H24NO2P | 233.292 | 3 / 2 | -0.9 | Yes |
| 555629 |  Aripiprazole | C23H27Cl2N3O2 | 448.388 | 4 / 1 | 4.6 | Yes |
| 555647 |  CGP44530 | C4H10NO2P | 135.103 | 3 / 2 | -1.6 | Yes |
| 46308 |  CHEMBL544301 | C21H22N2O2 | 334.419 | 3 / 2 | 3.4 | Yes |
| 52835 |  CID 11118897 | C9H15BrN2O2 | 263.135 | 3 / 2 | N/A | N/A |
| 555696 |  clonazepam | C15H10ClN3O3 | 315.713 | 4 / 1 | 2.4 | Yes |
| 59832 |  CID 10058852 | C8H18NO3P | 207.21 | 4 / 2 | -3.1 | Yes |
| 64725 |  CHEMBL555167 | C16H28N2O2 | 280.412 | 3 / 2 | 3.9 | Yes |
| 66502 |  CID 11026355 | C22H25BrN2O2 | 429.358 | 3 / 2 | N/A | N/A |
| 72982 |  CHEMBL541065 | C12H20N2O2 | 224.304 | 3 / 2 | 1.7 | Yes |
| 79554 |  CHEMBL377925 | C23H26N2O2 | 362.473 | 3 / 2 | 4.1 | Yes |
| 83256 |  CHEMBL541566 | C16H20N2O2 | 272.348 | 3 / 2 | 2.1 | Yes |
| 83767 |  CHEMBL111890 | C6H16NO2P | 165.173 | 3 / 2 | -3.1 | Yes |
| 84318 |  CHEMBL114128 | C10H15ClNO2P | 247.659 | 3 / 2 | -2.0 | Yes |
| 95468 |  Gabazine | C15H18BrN3O3 | 368.231 | 5 / 3 | N/A | N/A |
| 98576 |  CHEMBL543603 | C14H25BrN2O2 | 333.27 | 3 / 3 | N/A | N/A |
| 101844 |  SCHEMBL2951181 | C10H20NO3P | 233.248 | 4 / 2 | -2.2 | Yes |
| 555867 |  39069-52-8 | C15H23N5O2S | 337.442 | 7 / 2 | 5.2 | No |
| 104565 |  CHEMBL112639 | C10H22NO3P | 235.264 | 4 / 2 | -2.9 | Yes |
| 104962 |  CID 11748743 | C12H21BrN2O2 | 305.216 | 3 / 2 | N/A | N/A |
| 555880 |  66548-69-4 | C13H9F3N4 | 278.238 | 6 / 0 | 2.7 | Yes |
| 108336 |  CID 10993392 | C21H23BrN2O2 | 415.331 | 3 / 2 | N/A | N/A |
| 111824 |  CHEMBL544776 | C20H23BrN2O2 | 403.32 | 3 / 3 | N/A | N/A |
| 118067 |  CHEMBL555167 | C16H29BrN2O2 | 361.324 | 3 / 3 | N/A | N/A |
| 555942 |  Surinabant | C23H23BrCl2N4O | 522.268 | 3 / 1 | 7.0 | No |
| 121696 |  SCHEMBL6361016 | C7H16NO2P | 177.184 | 3 / 2 | -3.2 | Yes |
| 126058 |  CHEMBL553129 | C9H15BrN2O2 | 263.135 | 3 / 3 | N/A | N/A |
| 128387 |  CHEMBL115162 | C7H16NO3P | 193.183 | 4 / 2 | -4.3 | Yes |
| 130531 |  CID 10880819 | C11H19BrN2O2 | 291.189 | 3 / 2 | N/A | N/A |
| 553951 |  [125I]CGP71872 | C24H31IN5O7P | 657.418 | 10 / 6 | 0.8 | No |
| 553952 |  CGP 71872 | C24H31IN5O7P | 659.418 | 10 / 6 | 0.8 | No |
| 142406 |  CID 44341174 | C14H22N3O5P | 343.32 | 6 / 5 | -4.7 | Yes |
| 142770 |  CHEMBL541566 | C16H21BrN2O2 | 353.26 | 3 / 3 | N/A | N/A |
| 556031 |  (+)-Bicuculline | C20H17NO6 | 367.357 | 7 / 0 | 2.6 | Yes |
| 554009 |  CGP56999A | C19H30NO5P | 383.425 | 6 / 4 | -0.6 | Yes |
| 148807 |  CHEMBL1192583 | C9H14N2O2 | 182.223 | 3 / 2 | 0.4 | Yes |
| 554020 |  Cgp-54626 | C18H28Cl2NO3P | 408.3 | 4 / 3 | 1.1 | Yes |
| 151024 |  SCHEMBL6360421 | C7H18NO3P | 195.199 | 4 / 3 | -3.2 | Yes |
| 556074 |  ALPIDEM | C21H23Cl2N3O | 404.335 | 2 / 0 | 4.8 | Yes |
| 161467 |  CHEMBL544302 | C19H20N2O2 | 308.381 | 3 / 2 | 3.0 | Yes |
| 556121 |  Triton X-100 | C16H26O2 | 250.382 | 2 / 1 | 4.6 | Yes |
| 554104 |  saclofen | C9H12ClNO3S | 249.709 | 4 / 2 | -1.7 | Yes |
| 169241 |  CHEMBL321688 | C13H21ClNO3P | 305.739 | 4 / 3 | -1.8 | Yes |
| 556159 |  3-guanidinopropionate | C4H9N3O2 | 131.135 | 2 / 3 | -1.2 | Yes |
| 554164 |  (R)-Baclofen | C10H12ClNO2 | 213.661 | 3 / 2 | -1.0 | Yes |
| 189282 |  CID 11014600 | C19H21BrN2O2 | 389.293 | 3 / 2 | N/A | N/A |
| 486563 |  CHEMBL3640618 | C27H40N2O3 | 440.628 | 4 / 1 | 5.8 | No |
| 556238 |  haloperidol | C21H23ClFNO2 | 375.868 | 4 / 1 | 3.2 | Yes |
| 192979 |  CHEMBL323887 | C7H18NO2P | 179.2 | 3 / 2 | -2.6 | Yes |
| 200218 |  SCHEMBL6353357 | C7H18NO3P | 195.199 | 4 / 3 | -3.2 | Yes |
| 202684 |  CHEMBL113513 | C9H14NO2P | 199.19 | 3 / 2 | -2.4 | Yes |
| 202737 |  CHEMBL543603 | C14H24N2O2 | 252.358 | 3 / 2 | 2.8 | Yes |
| 206977 |  CID 10466077 | C9H20NO3P | 221.237 | 4 / 2 | -3.2 | Yes |
| 556299 |  AC1LAVCY | C6H11NO2 | 129.159 | 2 / 1 | -1.9 | Yes |
| 556300 |  37539-03-0 | C10H11N5O3S2 | 313.35 | 8 / 3 | -3.5 | Yes |
| 210152 |  CHEMBL552688 | C15H24N2O2 | 264.369 | 3 / 2 | 2.8 | Yes |
| 556310 |  GR 113808 | C19H27N3O4S | 393.502 | 6 / 1 | 1.7 | Yes |
| 556312 |  phosphopropyl amine | C3H8NO2P | 121.076 | 3 / 1 | -2.0 | Yes |
| 554336 |  3-aminopropylphosphinic acid | C3H9NO2P+ | 122.084 | 3 / 2 | -1.4 | Yes |
| 214839 |  CHEMBL323713 | C10H15FNO2P | 231.207 | 4 / 2 | -2.4 | Yes |
| 216061 |  CHEMBL540042 | C17H22N2O2 | 286.375 | 3 / 2 | 2.6 | Yes |
| 450211 |  CHEMBL114759 | C7H16NO3P | 193.183 | 4 / 2 | -3.3 | Yes |
| 223655 |  Phosphinic acid,P-(3-aminopropyl)-P-methyl- | C4H12NO2P | 137.119 | 2 / 1 | -1.8 | Yes |
| 225611 |  CHEMBL143993 | C10H16N2O2 | 196.25 | 3 / 2 | 0.6 | Yes |
| 556383 |  amisulpride | C17H27N3O4S | 369.48 | 6 / 2 | 1.5 | Yes |
| 232631 |  CHEMBL543125 | C23H22N2O2 | 358.441 | 3 / 2 | 4.3 | Yes |
| 556411 |  flumazenil | C15H14FN3O3 | 303.293 | 5 / 0 | 1.0 | Yes |
| 241979 |  CHEMBL545008 | C24H29BrN2O2 | 457.412 | 3 / 3 | N/A | N/A |
| 245814 |  Cgp-36742 | C7H18NO2P | 179.2 | 3 / 2 | -2.7 | Yes |
| 246768 |  CHEMBL326622 | C10H24NO4P | 253.279 | 5 / 2 | -2.4 | Yes |
| 252986 |  (Aminomethyl)(3-aminopropyl)phosphinic acid | C4H13N2O2P | 152.134 | 4 / 3 | -4.8 | Yes |
| 254607 |  CHEMBL144416 | C9H14N2O2 | 182.223 | 3 / 2 | 0.2 | Yes |
| 258567 |  CHEMBL112291 | C6H17N2O2P | 180.188 | 4 / 3 | -4.6 | Yes |
| 258584 |  CHEMBL113305 | C10H15ClNO3P | 263.658 | 4 / 3 | -3.0 | Yes |
| 260826 |  CHEMBL545238 | C20H23BrN2O2 | 403.32 | 3 / 3 | N/A | N/A |
| 556514 |  flunitrazepam | C16H12FN3O3 | 313.288 | 5 / 0 | 2.1 | Yes |
| 268441 |  CHEMBL543365 | C10H17BrN2O2 | 277.162 | 3 / 3 | N/A | N/A |
| 556523 |  4'-Chlorodiazepam | C16H12Cl2N2O | 319.185 | 2 / 0 | 3.8 | Yes |
| 556556 |  Fluorocarazolol | C18H21FN2O2 | 316.376 | 4 / 3 | 3.6 | Yes |
| 278995 |  CID 11069721 | C21H23BrN2O2 | 415.331 | 3 / 2 | N/A | N/A |
| 279016 |  Cgp 35348 | C8H20NO4P | 225.225 | 5 / 2 | -3.3 | Yes |
| 279684 |  SCHEMBL6360491 | C7H16NO3P | 193.183 | 4 / 2 | -3.5 | Yes |
| 283070 |  CHEMBL115664 | C12H28NO4P | 281.333 | 5 / 2 | -1.5 | Yes |
| 284171 |  CHEMBL114027 | C10H24NO4P | 253.279 | 5 / 2 | -2.2 | Yes |
| 284625 |  SCHEMBL6352033 | C10H16NO3P | 229.216 | 4 / 3 | -3.0 | Yes |
| 286843 |  CHEMBL144718 | C19H20N2O2 | 308.381 | 3 / 2 | 3.0 | Yes |
| 288060 |  3-Aminopropyl(hexyl)phosphinic acid | C9H22NO2P | 207.254 | 3 / 2 | -1.6 | Yes |
| 556613 |  PK 11195 | C21H21ClN2O | 352.862 | 2 / 0 | 5.5 | No |
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